ID   CLINK_MDV1              Reviewed;         169 AA.
AC   Q9Z0D2;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   23-FEB-2022, entry version 54.
DE   RecName: Full=Cell cycle link protein;
DE            Short=Clink;
GN   Name=DNA-C; Synonyms=C4;
OS   Milk vetch dwarf virus (isolate N) (MDV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Arfiviricetes;
OC   Mulpavirales; Nanoviridae; Nanovirus.
OX   NCBI_TaxID=291605;
OH   NCBI_TaxID=47065; Astragalus sinicus (Chinese milk vetch).
OH   NCBI_TaxID=3847; Glycine max (Soybean) (Glycine hispida).
OH   NCBI_TaxID=3885; Phaseolus vulgaris (Kidney bean) (French bean).
OH   NCBI_TaxID=3888; Pisum sativum (Garden pea).
OH   NCBI_TaxID=3906; Vicia faba (Broad bean) (Faba vulgaris).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9880029; DOI=10.1099/0022-1317-79-12-3111;
RA   Sano Y., Wada M., Hashimoto Y., Matsumoto T., Kojima M.;
RT   "Sequences of ten circular ssDNA components associated with the milk vetch
RT   dwarf virus genome.";
RL   J. Gen. Virol. 79:3111-3118(1998).
CC   -!- FUNCTION: Interacts with and disrupts the function of host
CC       retinoblastoma-related proteins RBR, which are key regulators of the
CC       cell cycle. Induces transcriptional activation of E2F-regulated S-phase
CC       and G2/M-phase-specific genes. Inactivation of the ability of RBR to
CC       arrest the cell cycle leads to the stimulation of viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host SKP1. Interacts (via LXCXE domain) with
CC       host retinoblastoma-related protein 1 (RBR1). Interacts (via LXCXE
CC       domain) with retinoblastoma-related proteins (RBR) (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nanovirus Clink protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB000923; BAA33983.1; -; Genomic_DNA.
DR   RefSeq; NP_619762.1; NC_003641.1.
DR   SMR; Q9Z0D2; -.
DR   GeneID; 995281; -.
DR   KEGG; vg:995281; -.
DR   Proteomes; UP000008236; Genome.
PE   3: Inferred from homology;
KW   Host-virus interaction.
FT   CHAIN           1..169
FT                   /note="Cell cycle link protein"
FT                   /id="PRO_0000338626"
FT   REGION          9..22
FT                   /note="Binding to host SKP1 protein"
FT                   /evidence="ECO:0000255"
FT   MOTIF           110..114
FT                   /note="LXCXE motif, interaction with host RBR"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   169 AA;  19691 MW;  E452505C8ACD3863 CRC64;
     MGLKYFAHLP LELREKIVRD HLQEERKKEF LEKAIEDSCR RHEALLIEDP SPAELNSLSK
     FLTALSDYVG NQFNTRCLIR WKKDVPSKVK FGFMDEQHHK LYGSMDMDDL SCGELFIPDE
     EDDLTYEDGV IVRCSQLDQL FKSLGIEIVY IVVSKHCIWA PLSKEIVIK