ID   CLINK_SCSVF             Reviewed;         164 AA.
AC   Q87010;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 45.
DE   RecName: Full=Cell cycle link protein;
DE            Short=Clink;
GN   Name=DNA-C; Synonyms=C3;
OS   Subterranean clover stunt virus (strain F) (SCSV).
OC   Viruses; Monodnaviria; Shotokuvirae; Cressdnaviricota; Arfiviricetes;
OC   Mulpavirales; Nanoviridae; Nanovirus.
OX   NCBI_TaxID=291607;
OH   NCBI_TaxID=3900; Trifolium subterraneum (Subterranean clover).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7886939; DOI=10.1006/viro.1995.1094;
RA   Boevink P.C., Chu P.W.G., Keese P.K.;
RT   "Sequence of subterranean clover stunt virus DNA: affinities with the
RT   geminiviruses.";
RL   Virology 207:354-361(1995).
CC   -!- FUNCTION: Interacts with and disrupts the function of host
CC       retinoblastoma-related proteins RBR, which are key regulators of the
CC       cell cycle. Induces transcriptional activation of E2F-regulated S-phase
CC       and G2/M-phase-specific genes. Inactivation of the ability of RBR to
CC       arrest the cell cycle leads to the stimulation of viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host SKP1. Interacts (via LXCXE domain) with
CC       host retinoblastoma-related protein 1 (RBR1). Interacts (via LXCXE
CC       domain) with retinoblastoma-related proteins (RBR) (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the nanovirus Clink protein family.
CC       {ECO:0000305}.
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DR   EMBL; U16732; AAA68019.1; -; Genomic_DNA.
DR   SMR; Q87010; -.
DR   Proteomes; UP000006543; Genome.
PE   3: Inferred from homology;
KW   Host-virus interaction; Reference proteome.
FT   CHAIN           1..164
FT                   /note="Cell cycle link protein"
FT                   /id="PRO_0000338628"
FT   REGION          9..22
FT                   /note="Binding to host SKP1 protein"
FT                   /evidence="ECO:0000255"
FT   MOTIF           111..115
FT                   /note="LXCXE motif, interaction with host RBR"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   164 AA;  19065 MW;  E315AA435A3B8131 CRC64;
     MALRYFSHLP EELKEKIMNE HLKEIKKKEF LENVIKAACA VFEGLTKKES VEEDDILRFS
     GFLEGLSAYY AEATKKKCLV RWKKSVAINL KWRVMEEMHY KLYGFADMED LYCSELGFPN
     YGEDDVAYHD GAIVNCKQLE VVFDDLGIEF MSIVIDRGSI KIEL