ID   CLIP3_XENLA             Reviewed;         534 AA.
AC   Q5U243;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=CAP-Gly domain-containing linker protein 3;
DE   AltName: Full=Cytoplasmic linker protein 170-related 59 kDa protein;
DE            Short=CLIP-170-related 59 kDa protein;
DE            Short=CLIPR-59;
GN   Name=clip3; Synonyms=clipr59;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a cytoplasmic linker protein. Involved in TGN-
CC       endosome dynamics (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack.
CC       Note=Localized to Golgi stacks as well as on tubulovesicular elements
CC       juxtaposed to Golgi cisternae.
CC   -!- DOMAIN: Microtubule association is inhibited by the ANK repeats and the
CC       Golgi localization region (GoLD). {ECO:0000250}.
CC   -!- MISCELLANEOUS: The N-terminal half is dispensable for proper Golgi
CC       targeting, whereas the GoLD region is required. {ECO:0000250}.
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DR   EMBL; BC086287; AAH86287.1; -; mRNA.
DR   RefSeq; NP_001088641.1; NM_001095172.1.
DR   AlphaFoldDB; Q5U243; -.
DR   SMR; Q5U243; -.
DR   DNASU; 495693; -.
DR   GeneID; 495693; -.
DR   KEGG; xla:495693; -.
DR   CTD; 495693; -.
DR   Xenbase; XB-GENE-6253473; clip3.S.
DR   OMA; ARCLLQH; -.
DR   OrthoDB; 482616at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 495693; Expressed in brain and 12 other tissues.
DR   GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 2.30.30.190; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036859; CAP-Gly_dom_sf.
DR   InterPro; IPR000938; CAP-Gly_domain.
DR   InterPro; IPR030504; CLIP3.
DR   PANTHER; PTHR18916:SF77; PTHR18916:SF77; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01302; CAP_GLY; 2.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM01052; CAP_GLY; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF74924; SSF74924; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS00845; CAP_GLY_1; 2.
DR   PROSITE; PS50245; CAP_GLY_2; 2.
PE   2: Evidence at transcript level;
KW   ANK repeat; Cytoplasm; Golgi apparatus; Reference proteome; Repeat.
FT   CHAIN           1..534
FT                   /note="CAP-Gly domain-containing linker protein 3"
FT                   /id="PRO_0000076214"
FT   REPEAT          107..148
FT                   /note="ANK 1"
FT   REPEAT          150..173
FT                   /note="ANK 2"
FT   REPEAT          187..299
FT                   /note="ANK 3"
FT   DOMAIN          304..346
FT                   /note="CAP-Gly 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00045"
FT   DOMAIN          423..465
FT                   /note="CAP-Gly 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00045"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          475..534
FT                   /note="GoLD"
FT   COMPBIAS        353..370
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   534 AA;  58739 MW;  906CEC2C66DF39E4 CRC64;
     MTREDLPDST PEESKLPMEF QSPLLEKRRR PVVHPSAPAP LPKDYAFTFF DPNDPACQEI
     LLDPQTSVPE LFAIIRQWVP QVQHKIDIIG SEILKRGCHV NDRDGLTDMT LLHYACKAGA
     HGVGDPAAAV RLTNQLLLLG ADITLRSRWT NMNALHYAAY FDVPELLRTL LKASKPKVLN
     STCSDFNHGT AMHIAASNLC LGAVKCLLEH GANPSARNSK SQVPADVVPD PMDMGLDKAD
     SAMIAKELKQ LLLDAVPLTC NLPKITLPNY DNIPGNLMLA SLGLKLGDRI LLDAEKAGTL
     RFCGTTEFAS GQWVGVELDE PDGKNDGSVG GIRYFICPPK QGIFAPVSKI SKAPDQPPSS
     VTSTPRTPRV DFSRVTGKGR KEKKATHKKS LSVGSLDREG LKIEIGDQVL VAGQKQGIVR
     FYGKTDFAPG YWFGIELEKP TGKHDGSVFG VRYFTCSAKN GVFAPPSRVQ RMGGPKDPQT
     DNNDMKKVHQ VTMTQPKRNF TKVRTPKEIA SENSMSRILF CCWFPWLLRA EMKS