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CLIP4_HUMAN
ID   CLIP4_HUMAN             Reviewed;         705 AA.
AC   Q8N3C7; A0AV10; B2RMQ3; B7Z7N8; Q7Z4U3; Q96BR7; Q96MA5; Q9H7C0;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=CAP-Gly domain-containing linker protein 4;
DE   AltName: Full=Restin-like protein 2;
GN   Name=CLIP4; Synonyms=RSNL2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA   Guo J.H., Yu L.;
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 102-705 (ISOFORMS 3 AND 4).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Amygdala;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 48-705 (ISOFORM 2).
RC   TISSUE=Lung, and Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 482-565.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Crystal structure of the 2nd CAP-Gly domain in human restin-like protein 2
RT   reveals a swapped-dimer.";
RL   Submitted (FEB-2009) to the PDB data bank.
CC   -!- INTERACTION:
CC       Q8N3C7; O75031: HSF2BP; NbExp=3; IntAct=EBI-5655540, EBI-7116203;
CC       Q8N3C7; Q96AA8: JAKMIP2; NbExp=7; IntAct=EBI-5655540, EBI-752007;
CC       Q8N3C7; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-5655540, EBI-2125614;
CC       Q8N3C7; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-5655540, EBI-14069005;
CC       Q8N3C7; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-5655540, EBI-741037;
CC       Q8N3C7; P43365: MAGEA12; NbExp=6; IntAct=EBI-5655540, EBI-749530;
CC       Q8N3C7; Q14244: MAP7; NbExp=3; IntAct=EBI-5655540, EBI-2211064;
CC       Q8N3C7; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-5655540, EBI-16439278;
CC       Q8N3C7; Q9NPC8: SIX2; NbExp=3; IntAct=EBI-5655540, EBI-12695166;
CC       Q8N3C7; Q13049: TRIM32; NbExp=6; IntAct=EBI-5655540, EBI-742790;
CC       Q8N3C7; Q15645: TRIP13; NbExp=3; IntAct=EBI-5655540, EBI-358993;
CC       Q8N3C7; Q8NC26: ZNF114; NbExp=7; IntAct=EBI-5655540, EBI-10265237;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q8N3C7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N3C7-2; Sequence=VSP_012971, VSP_012972;
CC       Name=3;
CC         IsoId=Q8N3C7-3; Sequence=VSP_012972;
CC       Name=4;
CC         IsoId=Q8N3C7-4; Sequence=VSP_012969, VSP_012970;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB14974.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF433661; AAP97312.1; -; mRNA.
DR   EMBL; AK024722; BAB14974.1; ALT_INIT; mRNA.
DR   EMBL; AK057267; BAB71403.1; -; mRNA.
DR   EMBL; AK302325; BAH13674.1; -; mRNA.
DR   EMBL; AL834443; CAD39103.1; -; mRNA.
DR   EMBL; CH471053; EAX00510.1; -; Genomic_DNA.
DR   EMBL; BC015310; AAH15310.2; -; mRNA.
DR   EMBL; BC126167; AAI26168.1; -; mRNA.
DR   EMBL; BC136331; AAI36332.1; -; mRNA.
DR   CCDS; CCDS1770.1; -. [Q8N3C7-1]
DR   CCDS; CCDS74502.1; -. [Q8N3C7-3]
DR   RefSeq; NP_001274456.1; NM_001287527.1. [Q8N3C7-1]
DR   RefSeq; NP_001274457.1; NM_001287528.1. [Q8N3C7-3]
DR   RefSeq; NP_078968.3; NM_024692.5. [Q8N3C7-1]
DR   RefSeq; XP_005264619.1; XM_005264562.2. [Q8N3C7-1]
DR   RefSeq; XP_005264620.1; XM_005264563.1. [Q8N3C7-1]
DR   RefSeq; XP_006712167.1; XM_006712104.2. [Q8N3C7-1]
DR   RefSeq; XP_011531411.1; XM_011533109.1. [Q8N3C7-1]
DR   RefSeq; XP_016860447.1; XM_017004958.1. [Q8N3C7-1]
DR   PDB; 2Z0W; X-ray; 2.50 A; A=482-564.
DR   PDBsum; 2Z0W; -.
DR   AlphaFoldDB; Q8N3C7; -.
DR   SMR; Q8N3C7; -.
DR   BioGRID; 122857; 44.
DR   IntAct; Q8N3C7; 34.
DR   STRING; 9606.ENSP00000327009; -.
DR   GlyGen; Q8N3C7; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8N3C7; -.
DR   PhosphoSitePlus; Q8N3C7; -.
DR   BioMuta; CLIP4; -.
DR   DMDM; 60390950; -.
DR   EPD; Q8N3C7; -.
DR   jPOST; Q8N3C7; -.
DR   MassIVE; Q8N3C7; -.
DR   MaxQB; Q8N3C7; -.
DR   PaxDb; Q8N3C7; -.
DR   PeptideAtlas; Q8N3C7; -.
DR   PRIDE; Q8N3C7; -.
DR   ProteomicsDB; 71789; -. [Q8N3C7-1]
DR   ProteomicsDB; 71790; -. [Q8N3C7-2]
DR   ProteomicsDB; 71791; -. [Q8N3C7-3]
DR   ProteomicsDB; 71792; -. [Q8N3C7-4]
DR   TopDownProteomics; Q8N3C7-4; -. [Q8N3C7-4]
DR   Antibodypedia; 51158; 129 antibodies from 24 providers.
DR   DNASU; 79745; -.
DR   Ensembl; ENST00000320081.10; ENSP00000327009.5; ENSG00000115295.21. [Q8N3C7-1]
DR   Ensembl; ENST00000401605.5; ENSP00000384242.1; ENSG00000115295.21. [Q8N3C7-3]
DR   Ensembl; ENST00000404424.5; ENSP00000385594.1; ENSG00000115295.21. [Q8N3C7-1]
DR   Ensembl; ENST00000690063.1; ENSP00000508552.1; ENSG00000115295.21. [Q8N3C7-1]
DR   Ensembl; ENST00000693264.1; ENSP00000509159.1; ENSG00000115295.21. [Q8N3C7-1]
DR   GeneID; 79745; -.
DR   KEGG; hsa:79745; -.
DR   MANE-Select; ENST00000320081.10; ENSP00000327009.5; NM_024692.6; NP_078968.3.
DR   UCSC; uc002rmu.5; human. [Q8N3C7-1]
DR   CTD; 79745; -.
DR   DisGeNET; 79745; -.
DR   GeneCards; CLIP4; -.
DR   HGNC; HGNC:26108; CLIP4.
DR   HPA; ENSG00000115295; Low tissue specificity.
DR   neXtProt; NX_Q8N3C7; -.
DR   OpenTargets; ENSG00000115295; -.
DR   PharmGKB; PA162382440; -.
DR   VEuPathDB; HostDB:ENSG00000115295; -.
DR   eggNOG; KOG0241; Eukaryota.
DR   eggNOG; KOG4568; Eukaryota.
DR   GeneTree; ENSGT00940000157706; -.
DR   HOGENOM; CLU_023687_1_0_1; -.
DR   InParanoid; Q8N3C7; -.
DR   OMA; RCRWTNM; -.
DR   OrthoDB; 482616at2759; -.
DR   PhylomeDB; Q8N3C7; -.
DR   TreeFam; TF326096; -.
DR   PathwayCommons; Q8N3C7; -.
DR   SignaLink; Q8N3C7; -.
DR   BioGRID-ORCS; 79745; 6 hits in 1071 CRISPR screens.
DR   ChiTaRS; CLIP4; human.
DR   EvolutionaryTrace; Q8N3C7; -.
DR   GenomeRNAi; 79745; -.
DR   Pharos; Q8N3C7; Tdark.
DR   PRO; PR:Q8N3C7; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q8N3C7; protein.
DR   Bgee; ENSG00000115295; Expressed in secondary oocyte and 181 other tissues.
DR   ExpressionAtlas; Q8N3C7; baseline and differential.
DR   Genevisible; Q8N3C7; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0035371; C:microtubule plus-end; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0051010; F:microtubule plus-end binding; IBA:GO_Central.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 2.30.30.190; -; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR036859; CAP-Gly_dom_sf.
DR   InterPro; IPR000938; CAP-Gly_domain.
DR   InterPro; IPR028397; CLIP4.
DR   PANTHER; PTHR18916:SF32; PTHR18916:SF32; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01302; CAP_GLY; 3.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM01052; CAP_GLY; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF74924; SSF74924; 3.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS00845; CAP_GLY_1; 2.
DR   PROSITE; PS50245; CAP_GLY_2; 3.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; ANK repeat; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..705
FT                   /note="CAP-Gly domain-containing linker protein 4"
FT                   /id="PRO_0000083529"
FT   REPEAT          65..101
FT                   /note="ANK 1"
FT   REPEAT          149..180
FT                   /note="ANK 2"
FT   REPEAT          186..215
FT                   /note="ANK 3"
FT   DOMAIN          303..345
FT                   /note="CAP-Gly 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00045"
FT   DOMAIN          505..547
FT                   /note="CAP-Gly 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00045"
FT   DOMAIN          644..686
FT                   /note="CAP-Gly 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00045"
FT   REGION          391..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          431..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        391..408
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         557
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q66HD5"
FT   MOD_RES         609
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CI96"
FT   VAR_SEQ         1..150
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_012969"
FT   VAR_SEQ         468..705
FT                   /note="LNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIEL
FT                   EKPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRR
FT                   SFSTTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLHEGSQVLLTSSNEM
FT                   GTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYRGIN
FT                   GSKLVDENC -> IYGFFNQAFLVFFILVCLFEFLSNIYSK (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_012970"
FT   VAR_SEQ         511
FT                   /note="P -> PVL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_012971"
FT   VAR_SEQ         600..705
FT                   /note="Missing (in isoform 2 and isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_012972"
FT   VARIANT         486
FT                   /note="R -> L (in dbSNP:rs3100246)"
FT                   /id="VAR_048675"
FT   VARIANT         613
FT                   /note="T -> P (in dbSNP:rs34327508)"
FT                   /id="VAR_048676"
FT   CONFLICT        321
FT                   /note="E -> G (in Ref. 2; BAB14974)"
FT                   /evidence="ECO:0000305"
FT   STRAND          499..505
FT                   /evidence="ECO:0007829|PDB:2Z0W"
FT   STRAND          508..512
FT                   /evidence="ECO:0007829|PDB:2Z0W"
FT   STRAND          514..522
FT                   /evidence="ECO:0007829|PDB:2Z0W"
FT   STRAND          524..530
FT                   /evidence="ECO:0007829|PDB:2Z0W"
FT   STRAND          533..536
FT                   /evidence="ECO:0007829|PDB:2Z0W"
FT   STRAND          542..546
FT                   /evidence="ECO:0007829|PDB:2Z0W"
FT   HELIX           548..550
FT                   /evidence="ECO:0007829|PDB:2Z0W"
SQ   SEQUENCE   705 AA;  76317 MW;  2BE72B2DD2206F12 CRC64;
     MTIEDLPDFP LEGNPLFGRY PFIFSASDTP VIFSISAAPM PSDCEFSFFD PNDASCQEIL
     FDPKTSVSEL FAILRQWVPQ VQQNIDIIGN EILKRGCNVN DRDGLTDMTL LHYTCKSGAH
     GIGDVETAVK FATQLIDLGA DISLRSRWTN MNALHYAAYF DVPELIRVIL KTSKPKDVDA
     TCSDFNFGTA LHIAAYNLCA GAVKCLLEQG ANPAFRNDKG QIPADVVPDP VDMPLEMADA
     AATAKEIKQM LLDAVPLSCN ISKAMLPNYD HVTGKAMLTS LGLKLGDRVV IAGQKVGTLR
     FCGTTEFASG QWAGIELDEP EGKNNGSVGK VQYFKCAPKY GIFAPLSKIS KAKGRRKNIT
     HTPSTKAAVP LIRSQKIDVA HVTSKVNTGL MTSKKDSASE STLSLPPGEE LKTVTEKDVA
     LLGSVSSCSS TSSLEHRQSY PKKQNAISSN KKTMSKSPSL SSRASAGLNS SATSTANNSR
     CEGELRLGER VLVVGQRLGT IRFFGTTNFA PGYWYGIELE KPHGKNDGSV GGVQYFSCSP
     RYGIFAPPSR VQRVTDSLDT LSEISSNKQN HSYPGFRRSF STTSASSQKE INRRNAFSKS
     KAALRRSWSS TPTAGGIEGS VKLHEGSQVL LTSSNEMGTV RYVGPTDFAS GIWLGLELRS
     AKGKNDGSVG DKRYFTCKPN HGVLVRPSRV TYRGINGSKL VDENC
 
 
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