CLIP4_RAT
ID CLIP4_RAT Reviewed; 599 AA.
AC Q66HD5;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=CAP-Gly domain-containing linker protein 4;
DE AltName: Full=Restin-like protein 2;
GN Name=Clip4; Synonyms=Rsnl2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
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DR EMBL; BC081910; AAH81910.1; -; mRNA.
DR RefSeq; NP_001013964.1; NM_001013942.1.
DR AlphaFoldDB; Q66HD5; -.
DR SMR; Q66HD5; -.
DR STRING; 10116.ENSRNOP00000063078; -.
DR iPTMnet; Q66HD5; -.
DR PhosphoSitePlus; Q66HD5; -.
DR PaxDb; Q66HD5; -.
DR PRIDE; Q66HD5; -.
DR GeneID; 298801; -.
DR KEGG; rno:298801; -.
DR UCSC; RGD:1311049; rat.
DR CTD; 79745; -.
DR RGD; 1311049; Clip4.
DR eggNOG; KOG4568; Eukaryota.
DR InParanoid; Q66HD5; -.
DR OrthoDB; 482616at2759; -.
DR PRO; PR:Q66HD5; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0035371; C:microtubule plus-end; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051010; F:microtubule plus-end binding; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 2.30.30.190; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR028397; CLIP4.
DR PANTHER; PTHR18916:SF32; PTHR18916:SF32; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01302; CAP_GLY; 2.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01052; CAP_GLY; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF74924; SSF74924; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..599
FT /note="CAP-Gly domain-containing linker protein 4"
FT /id="PRO_0000083531"
FT REPEAT 65..101
FT /note="ANK 1"
FT REPEAT 149..180
FT /note="ANK 2"
FT REPEAT 186..215
FT /note="ANK 3"
FT DOMAIN 303..345
FT /note="CAP-Gly 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00045"
FT DOMAIN 505..547
FT /note="CAP-Gly 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00045"
FT REGION 387..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 557
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 599 AA; 64645 MW; 82DAD16A014DCE21 CRC64;
MTIEDLPDIP LEGSSLIGRY PFLFTGSDTS VIFSISAAPM PSDCEFSFFD PNDASCQEIL
FDPKTSVSEL FAILRQWVPQ VQQNIDIIGN EILKRGCNVN DRDGLTDMTL LHYTCKSGAH
GIGDVETAVK FAAQLIDLGA DASLRSRWTN MNALHYASYF DVPELIRVLL KTSKPKDVDA
TCSDFNFGTA LHIAAHNLCA GAVKTLLELG ANPAFRNDKG QIPADVVPDP VDMPLEMADA
AAIAKEIKQM LLDSMPLPCT ITKATLPNCD ITTSKAMLTT LGLKLGDRVV IAGQKVGTLR
FCGTTEFASG QWAGIELDEP EGKNNGSVGR VQYFKCAPKY GIFAPLSKIT KVKDGRKNIT
HTPSTKATLH ARSQKVDVAH VTSKVNSGLM TSKKENASES TLSLPRSEEL KTVAKNDATQ
PGCISSSSST SSLDHKQSHP KKLSTSSSSG KKTLSKSPSL PSRASAGLKS STTSAANNTH
REGALRLGER VLVVGQRVGT IKFFGTTNFA PGYWYGIELE KPHGKNDGSV GGVQYFSCSP
RYGIFAPPSR VQRLSDSLDT LSEISSNKQN HSYPGFRRSF STTSASSQKE INRRNAFAK