CLIT1_CLINE
ID CLIT1_CLINE Reviewed; 152 AA.
AC Q96V81;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 25.
DE RecName: Full=Clitocypin-1;
DE AltName: Full=Cysteine protease inhibitor;
OS Clitocybe nebularis (Clouded agaric) (Lepista nebularis).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Tricholomataceae; Clitocybe.
OX NCBI_TaxID=117024;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Kras2004;
RX PubMed=17132101; DOI=10.1515/bc.2006.194;
RA Sabotic J., Gaser D., Rogelj B., Gruden K., Strukelj B., Brzin J.;
RT "Heterogeneity in the cysteine protease inhibitor clitocypin gene family.";
RL Biol. Chem. 387:1559-1566(2006).
CC -!- FUNCTION: Binds and inhibits cysteine proteinases. Inhibits most
CC strongly papain and cathepsin L, more weakly bromelain and cathepsin B
CC while it is completely ineffective against cathepsin H.
CC {ECO:0000250|UniProtKB:Q9P4A2}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9P4A2}.
CC -!- SUBCELLULAR LOCATION: Note=Not secreted.
CC {ECO:0000250|UniProtKB:Q9P4A2}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I48 family.
CC {ECO:0000305}.
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DR EMBL; AF298881; AAK97207.1; -; Genomic_DNA.
DR SMR; Q96V81; -.
DR MEROPS; I48.001; -.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR019508; Prot_inh_I48_clitocypin.
DR Pfam; PF10467; Inhibitor_I48; 1.
PE 3: Inferred from homology;
KW Protease inhibitor; Thiol protease inhibitor.
FT CHAIN 1..152
FT /note="Clitocypin-1"
FT /id="PRO_0000453199"
SQ SEQUENCE 152 AA; 16925 MW; DD77D41501F1B71A CRC64;
MASLEDGIYR LRAVTTHNPD PGVGGEYATV EGARQPVKAE PSTPPFFERQ IWQVTRNSDG
QSTIKYQGLN TPFEYGFSYD QLEQNAPVIA GDPKEYILQL VPSTTDVYII RAPIQRVGVD
VEVGVQGNNL VYKFFPVDGS GGDRPAWRFT RE