ID   CLIT4_CLINE             Reviewed;         152 AA.
AC   Q3Y9I2;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 21.
DE   RecName: Full=Clitocypin-4/-3;
DE   AltName: Full=Cysteine protease inhibitor clt4/clt3;
GN   Name=clt4; Synonyms=clt3;
OS   Clitocybe nebularis (Clouded agaric) (Lepista nebularis).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Tricholomataceae; Clitocybe.
OX   NCBI_TaxID=117024;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Vrh2004;
RX   PubMed=17132101; DOI=10.1515/bc.2006.194;
RA   Sabotic J., Gaser D., Rogelj B., Gruden K., Strukelj B., Brzin J.;
RT   "Heterogeneity in the cysteine protease inhibitor clitocypin gene family.";
RL   Biol. Chem. 387:1559-1566(2006).
CC   -!- FUNCTION: Binds and inhibits cysteine proteinases. Inhibits most
CC       strongly papain and cathepsin L, more weakly bromelain and cathepsin B
CC       while it is completely ineffective against cathepsin H.
CC       {ECO:0000250|UniProtKB:Q9P4A2}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9P4A2}.
CC   -!- SUBCELLULAR LOCATION: Note=Not secreted.
CC       {ECO:0000250|UniProtKB:Q9P4A2}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I48 family.
CC       {ECO:0000305}.
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DR   EMBL; DQ150591; AAZ78484.1; -; Genomic_DNA.
DR   EMBL; DQ150592; AAZ78485.1; -; Genomic_DNA.
DR   SMR; Q3Y9I2; -.
DR   MEROPS; I48.001; -.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019508; Prot_inh_I48_clitocypin.
DR   Pfam; PF10467; Inhibitor_I48; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor; Thiol protease inhibitor.
FT   CHAIN           1..152
FT                   /note="Clitocypin-4/-3"
FT                   /id="PRO_0000453200"
SQ   SEQUENCE   152 AA;  16893 MW;  866D05AD6E361D41 CRC64;
     MASLEDGTYR LRAVTTSNPD PGVGGEYATV EGARQPVKAE PSTPPFFERQ IWQVTRNADG
     QYTIKYQGLN APFEYGFSYD QLEQNAPVIA GDPKEYILQL VPSTTDVYII RAPIQRVGVD
     VEVGVQGNNL VYKFFPVDGS GGDRPAWRFT RE