ID   CLIT6_CLINE             Reviewed;         152 AA.
AC   Q3Y9I5;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 18.
DE   RecName: Full=Clitocypin-6;
DE   AltName: Full=Cysteine protease inhibitor clt6;
GN   Name=clt6;
OS   Clitocybe nebularis (Clouded agaric) (Lepista nebularis).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Tricholomataceae; Clitocybe.
OX   NCBI_TaxID=117024;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Vrh2004;
RX   PubMed=17132101; DOI=10.1515/bc.2006.194;
RA   Sabotic J., Gaser D., Rogelj B., Gruden K., Strukelj B., Brzin J.;
RT   "Heterogeneity in the cysteine protease inhibitor clitocypin gene family.";
RL   Biol. Chem. 387:1559-1566(2006).
CC   -!- FUNCTION: Binds and inhibits cysteine proteinases. Inhibits most
CC       strongly papain and cathepsin L, more weakly bromelain and cathepsin B
CC       while it is completely ineffective against cathepsin H.
CC       {ECO:0000250|UniProtKB:Q9P4A2}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9P4A2}.
CC   -!- SUBCELLULAR LOCATION: Note=Not secreted.
CC       {ECO:0000250|UniProtKB:Q9P4A2}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I48 family.
CC       {ECO:0000305}.
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DR   EMBL; DQ150589; AAZ78482.1; -; mRNA.
DR   SMR; Q3Y9I5; -.
DR   MEROPS; I48.001; -.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR019508; Prot_inh_I48_clitocypin.
DR   Pfam; PF10467; Inhibitor_I48; 1.
PE   2: Evidence at transcript level;
KW   Protease inhibitor; Thiol protease inhibitor.
FT   CHAIN           1..152
FT                   /note="Clitocypin-6"
FT                   /id="PRO_0000453201"
SQ   SEQUENCE   152 AA;  16991 MW;  03180CDCA2D32B65 CRC64;
     MASLEDGTYR LRAVTTHNPD PGVGGEYATV EGARQPVKAE PNTPPFFERQ YWQVTRNADG
     QYTIKYQGLN TPFEYGFSYD ELEPNAPVIA GDPKEYILQL VPSTTDVYII RAPIQRVGVD
     VEVGVQENTL VYKIFPVDGS GGDKAAWRFT RE