CLK2_CAEEL
ID CLK2_CAEEL Reviewed; 877 AA.
AC Q95YE9; Q95NL2;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Telomere length regulation protein clk-2;
DE AltName: Full=Clock abnormal protein 2;
GN Name=clk-2; Synonyms=rad-5 {ECO:0000303|PubMed:16951081}; ORFNames=C07H6.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=11696330; DOI=10.1016/s0960-9822(01)00526-7;
RA Lim C.S., Mian S., Dernburg A.F., Campisi J.;
RT "C. elegans clk-2, a gene that limits life span, encodes a telomere length
RT regulator similar to yeast telomere binding protein Tel2p.";
RL Curr. Biol. 11:1706-1710(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=11641227; DOI=10.1242/dev.128.20.4045;
RA Benard C., McCright B., Zhang Y., Felkai S., Lakowski B., Hekimi S.;
RT "The C. elegans maternal-effect gene clk-2 is essential for embryonic
RT development, encodes a protein homologous to yeast Tel2p and affects
RT telomere length.";
RL Development 128:4045-4055(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP FUNCTION.
RX PubMed=10882129; DOI=10.1016/s1097-2765(00)80438-4;
RA Gartner A., Milstein S., Ahmed S., Hodgkin J., Hengartner M.O.;
RT "A conserved checkpoint pathway mediates DNA damage-induced apoptosis and
RT cell cycle arrest in C. elegans.";
RL Mol. Cell 5:435-443(2000).
RN [5]
RP FUNCTION.
RX PubMed=16951081; DOI=10.1534/genetics.106.058701;
RA Harris J., Lowden M., Clejan I., Tzoneva M., Thomas J.H., Hodgkin J.,
RA Ahmed S.;
RT "Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint
RT mutants.";
RL Genetics 174:601-616(2006).
CC -!- FUNCTION: DNA damage checkpoint protein required for DNA damage-induced
CC cell cycle arrest and apoptosis, thereby playing a role in genome
CC stability (PubMed:10882129, PubMed:16951081). Regulator of telomere
CC length (PubMed:11696330, PubMed:11641227).
CC {ECO:0000269|PubMed:10882129, ECO:0000269|PubMed:11641227,
CC ECO:0000269|PubMed:11696330, ECO:0000269|PubMed:16951081}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome, telomere
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TEL2 family. {ECO:0000305}.
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DR EMBL; AJ320257; CAC44622.1; -; mRNA.
DR EMBL; AF400665; AAL28024.1; -; mRNA.
DR EMBL; FO080423; CCD63593.1; -; Genomic_DNA.
DR RefSeq; NP_498650.2; NM_066249.3.
DR AlphaFoldDB; Q95YE9; -.
DR BioGRID; 41273; 91.
DR STRING; 6239.C07H6.6; -.
DR EPD; Q95YE9; -.
DR PaxDb; Q95YE9; -.
DR PeptideAtlas; Q95YE9; -.
DR EnsemblMetazoa; C07H6.6.1; C07H6.6.1; WBGene00000537.
DR GeneID; 176065; -.
DR UCSC; C07H6.6; c. elegans.
DR CTD; 176065; -.
DR WormBase; C07H6.6; CE30240; WBGene00000537; clk-2.
DR eggNOG; KOG4346; Eukaryota.
DR GeneTree; ENSGT00390000006698; -.
DR HOGENOM; CLU_005579_0_0_1; -.
DR InParanoid; Q95YE9; -.
DR OMA; PHRFSEN; -.
DR OrthoDB; 823649at2759; -.
DR PhylomeDB; Q95YE9; -.
DR PRO; PR:Q95YE9; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000537; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0070209; C:ASTRA complex; IBA:GO_Central.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IMP:WormBase.
DR GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR GO; GO:0009411; P:response to UV; IMP:WormBase.
DR GO; GO:0010165; P:response to X-ray; IMP:WormBase.
DR GO; GO:0000723; P:telomere maintenance; IDA:WormBase.
DR GO; GO:0007004; P:telomere maintenance via telomerase; IBA:GO_Central.
DR Gene3D; 1.25.40.720; -; 1.
DR InterPro; IPR038528; TEL2_C_sf.
DR InterPro; IPR019337; Telomere_length_regulation_dom.
DR Pfam; PF10193; Telomere_reg-2; 1.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Nucleus; Reference proteome; Telomere.
FT CHAIN 1..877
FT /note="Telomere length regulation protein clk-2"
FT /id="PRO_0000215560"
FT REGION 488..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 99836 MW; AA9CFF47C74A2714 CRC64;
MNLRSRLVNA TERAVLFQIF KDVQNDPEKY DNAVEAICES IDYFGKFLTD SEYLTQIKPI
LDTQCPTKSI ICFSKCLTKV STDINTTTFR DVITMLDWLK YVVEKSLTSA ICSSLKVKET
DVSAVQLYRE FASACSNIPE KVSNCCAKAL SGEHVKYINT VKWIFKMNLV QGIQKAMLLA
HDDIVTAAPF TSFYGSGGPY MKTVAEIISS GRNIDITNKD GLLVQMIEWI GSLNNFDSQW
RRMMFLIFQE PTYQGIQVHE SLLTTLFLIS KSDQILKRCI EATDLTGTLK RVVMVKLPFQ
RVLKRKTIEI LINFVYRTKE QFAIQLLETS VKIWSDLNYA KSAPESQERH IVRMILYLVH
LFRTCSSIDW ESLFLNSMDG VHCRMSMLPM YVQSGIFVNQ ALCKQATKHR SKTHGSDEQP
PETLEENKFV SSEVGKIWFE EMTSILEHGF NSSTVKDSER VRETANEITK DDSGEEFEET
NAQRLQNNKD SAAITSKNNL RLDSDDDEDF PDYQVNESEK IFKNLEIGEE PKNKVTPPAY
IADAFEMLLE KEKYEVFEAA FFNITNLINR RPIGFPQIAE KLFIRILHLQ NNFGTPKFKE
TVDEIAVACI TQRPEIVPSV VRLIIAPGQG FSIKQRLLHY IHNAADGMGA LDKKLEECVM
AQQLRIGGPT LSIILHRTIN TDYDDEDEDP HRLLVPEWRR MVDARIAANT RRIGTTREPP
RAGVVNRLAQ AAKYMFYPLL VLPRGENASL LGKDSDLLAS LIMVASMVYV RCGVCPQIHR
MSSELISYAT PHRFSENAKL RTACIIAHLN VTTLLPGDLM DELFDVPALI GWFDWANSVL
VNASSSQLEK DMTRQFGHSV TKHLQRYHPA VLQHQDV
