ID   CLKTX_LYCMC             Reviewed;          58 AA.
AC   P0CI88;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Putative calcium channel toxin 196;
DE   Flags: Precursor; Fragment;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Yunnan; TISSUE=Venom gland;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
CC   -!- FUNCTION: May inhibit voltage-gated potassium channels Kv1.1/KCNA1,
CC       hKv1.2/KCNA2, and Kv1.3/KCNA3 (By similarity). May also increase
CC       intracellular calcium release through the activation of nuclear
CC       inositol 1,4,5-trisphosphate receptors (ITPR) of cardiomyocytes,
CC       thereby causing an increase in the contraction frequency of these cells
CC       (By similarity). {ECO:0000250|UniProtKB:P0DJL0,
CC       ECO:0000250|UniProtKB:P0DM29}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:20663230}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:20663230}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:P59868}.
CC   -!- SIMILARITY: Belongs to the scorpion calcin-like family. KTX subfamily.
CC       {ECO:0000305}.
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DR   EMBL; GT029194; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0CI88; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Calcium channel impairing toxin; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin;
KW   Ryanodine-sensitive calcium-release channel impairing toxin; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          <1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..26
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403856"
FT   CHAIN           27..58
FT                   /note="Putative calcium channel toxin 196"
FT                   /id="PRO_0000403857"
FT   DISULFID        25..38
FT                   /evidence="ECO:0000250|UniProtKB:P59868"
FT   DISULFID        31..43
FT                   /evidence="ECO:0000250|UniProtKB:P59868"
FT   DISULFID        37..52
FT                   /evidence="ECO:0000250|UniProtKB:P59868"
FT   NON_TER         1
SQ   SEQUENCE   58 AA;  6425 MW;  955F3C492C21B2B8 CRC64;
     GSLLLVLFLL SVICYAEIAA GPTKCQYGRP CDSDRDCCWE YRCLSSGEEY TCKQDPGP