ID   CLLU1_HUMAN             Reviewed;         121 AA.
AC   Q5K131;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Chronic lymphocytic leukemia up-regulated protein 1;
GN   Name=CLLU1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Blood;
RX   PubMed=16339396; DOI=10.1182/blood-2005-07-2615;
RA   Buhl A.M., Jurlander J., Joergensen F.S., Ottesen A.M., Cowland J.B.,
RA   Gjerdrum L.M., Hansen B.V., Leffers H.;
RT   "Identification of a gene on chromosome 12q22 uniquely overexpressed in
RT   chronic lymphocytic leukemia.";
RL   Blood 107:2904-2911(2006).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=17284524; DOI=10.1182/blood-2006-11-054916;
RA   Josefsson P., Geisler C.H., Leffers H., Petersen J.H., Andersen M.K.,
RA   Jurlander J., Buhl A.M.;
RT   "CLLU1 expression analysis adds prognostic information to risk prediction
RT   in chronic lymphocytic leukemia.";
RL   Blood 109:4973-4979(2007).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=19726446; DOI=10.1101/gr.095026.109;
RA   Knowles D.G., McLysaght A.;
RT   "Recent de novo origin of human protein-coding genes.";
RL   Genome Res. 19:1752-1759(2009).
RN   [4]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=19212335; DOI=10.1038/leu.2009.16;
RA   Buhl A.M., Novotny G.W., Josefsson P., Nielsen J.E., Pedersen L.B.,
RA   Geisler C., Rassenti L.Z., Kipps T.J., Jurlander J., Leffers H.;
RT   "The CLLU1 expression level is a stable and inherent feature of the chronic
RT   lymphocytic leukemia clone.";
RL   Leukemia 23:1182-1186(2009).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19212335}.
CC       Note=Detected in the cytoplasm of chronic lymphocytic leukemia (CLL)
CC       cells.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in chronic lymphocytic
CC       leukemia (CLL) cells from patients without immunoglobulin heavy-chain
CC       hypermutations. Expression is detected in all CLL cells and levels are
CC       similar in patients before and after treatment.
CC       {ECO:0000269|PubMed:16339396, ECO:0000269|PubMed:17284524,
CC       ECO:0000269|PubMed:19212335}.
CC   -!- MISCELLANEOUS: Tridimensional modeling predicts that it may interact
CC       with the IL-4 receptor.
CC   -!- MISCELLANEOUS: This protein has no orthologs in other species and
CC       appears to be the product of a protein-coding gene which has arisen
CC       since divergence from chimp.
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DR   EMBL; AJ845165; CAH61080.1; -; mRNA.
DR   EMBL; AJ845166; CAH61081.1; -; mRNA.
DR   AlphaFoldDB; Q5K131; -.
DR   STRING; 9606.ENSP00000367746; -.
DR   BioMuta; CLLU1; -.
DR   PaxDb; Q5K131; -.
DR   PRIDE; Q5K131; -.
DR   UCSC; uc001tcf.3; human.
DR   GeneCards; CLLU1; -.
DR   HGNC; HGNC:29841; CLLU1.
DR   MIM; 616988; gene.
DR   neXtProt; NX_Q5K131; -.
DR   HOGENOM; CLU_2037263_0_0_1; -.
DR   Pharos; Q5K131; Tbio.
DR   PRO; PR:Q5K131; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q5K131; protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..121
FT                   /note="Chronic lymphocytic leukemia up-regulated protein 1"
FT                   /id="PRO_0000297649"
FT   VARIANT         9
FT                   /note="S -> F (in dbSNP:rs12580153)"
FT                   /id="VAR_034663"
SQ   SEQUENCE   121 AA;  14228 MW;  517B5EE827F5A5D1 CRC64;
     MFNKCSFHSS IYRPAADNSA SSLCAIICFL NLVIECDLET NSEINKLIIY LFSQNNRIRF
     SKLLLKILFY ISIFSYPELM CEQYVTFIKP GIHYGQVSKK HIIYSTFLSK NFKFQLLRVC
     W