CLM2_HUMAN
ID CLM2_HUMAN Reviewed; 205 AA.
AC Q496F6; B4DNS1; Q7Z7I3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=CMRF35-like molecule 2;
DE Short=CLM-2;
DE AltName: Full=CD300 antigen-like family member E;
DE AltName: Full=CMRF35-A5;
DE AltName: Full=Immune receptor expressed on myeloid cells 2;
DE Short=IREM-2;
DE AltName: Full=Polymeric immunoglobulin receptor 2;
DE Short=PIgR-2;
DE Short=PIgR2;
DE Short=Poly-Ig receptor 2;
DE AltName: CD_antigen=CD300e;
DE Flags: Precursor;
GN Name=CD300E; Synonyms=CD300LE, CLM2, CMRF35A5, IREM2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION,
RP INTERACTION WITH TYROBP, AND VARIANT THR-19.
RC TISSUE=Peripheral blood monocyte;
RX PubMed=15557162; DOI=10.4049/jimmunol.173.11.6703;
RA Aguilar H., Alvarez-Errico D., Garcia-Montero A.C., Orfao A., Sayos J.,
RA Lopez-Botet M.;
RT "Molecular characterization of a novel immune receptor restricted to the
RT monocytic lineage.";
RL J. Immunol. 173:6703-6711(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-158.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-158.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION.
RX PubMed=12483297; DOI=10.1007/s00439-002-0851-y;
RA Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L.,
RA Taillon-Miller P., Kwok P.Y., Menter A., Bowcock A.M.;
RT "Novel immunoglobulin superfamily gene cluster, mapping to a region of
RT human chromosome 17q25, linked to psoriasis susceptibility.";
RL Hum. Genet. 112:34-41(2003).
RN [7]
RP VARIANT [LARGE SCALE ANALYSIS] ALA-27.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Probably acts as an activating receptor.
CC {ECO:0000269|PubMed:15557162}.
CC -!- SUBUNIT: Interacts with TYROBP. {ECO:0000269|PubMed:15557162}.
CC -!- INTERACTION:
CC Q496F6; A8K4G0: CD300LB; NbExp=2; IntAct=EBI-18010148, EBI-26499879;
CC Q496F6; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-18010148, EBI-12019274;
CC Q496F6; Q9UNK0: STX8; NbExp=3; IntAct=EBI-18010148, EBI-727240;
CC Q496F6; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-18010148, EBI-11988865;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein.
CC -!- TISSUE SPECIFICITY: Present on the surface of mature hematopoietic
CC cells of the monocyte and myeloid lineages (at protein level).
CC {ECO:0000269|PubMed:15557162}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:15557162}.
CC -!- SIMILARITY: Belongs to the CD300 family. {ECO:0000305}.
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DR EMBL; AF395839; AAP42154.1; -; mRNA.
DR EMBL; AK298031; BAG60333.1; -; mRNA.
DR EMBL; AC064805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89176.1; -; Genomic_DNA.
DR EMBL; BC100888; AAI00889.1; -; mRNA.
DR EMBL; BC100889; AAI00890.1; -; mRNA.
DR EMBL; BC100890; AAI00891.1; -; mRNA.
DR CCDS; CCDS11702.1; -.
DR RefSeq; NP_852114.2; NM_181449.2.
DR AlphaFoldDB; Q496F6; -.
DR SMR; Q496F6; -.
DR BioGRID; 131180; 18.
DR IntAct; Q496F6; 14.
DR MINT; Q496F6; -.
DR STRING; 9606.ENSP00000376395; -.
DR GlyGen; Q496F6; 2 sites, 2 O-linked glycans (1 site).
DR iPTMnet; Q496F6; -.
DR PhosphoSitePlus; Q496F6; -.
DR BioMuta; CD300E; -.
DR DMDM; 296434454; -.
DR jPOST; Q496F6; -.
DR MassIVE; Q496F6; -.
DR PaxDb; Q496F6; -.
DR PeptideAtlas; Q496F6; -.
DR PRIDE; Q496F6; -.
DR ProteomicsDB; 61989; -.
DR Antibodypedia; 2708; 300 antibodies from 28 providers.
DR DNASU; 342510; -.
DR Ensembl; ENST00000392619.2; ENSP00000376395.2; ENSG00000186407.7.
DR GeneID; 342510; -.
DR KEGG; hsa:342510; -.
DR MANE-Select; ENST00000392619.2; ENSP00000376395.2; NM_181449.3; NP_852114.2.
DR UCSC; uc002jlb.3; human.
DR CTD; 342510; -.
DR DisGeNET; 342510; -.
DR GeneCards; CD300E; -.
DR HGNC; HGNC:28874; CD300E.
DR HPA; ENSG00000186407; Tissue enhanced (bone marrow, lymphoid tissue).
DR MIM; 609801; gene.
DR neXtProt; NX_Q496F6; -.
DR OpenTargets; ENSG00000186407; -.
DR PharmGKB; PA142672152; -.
DR VEuPathDB; HostDB:ENSG00000186407; -.
DR eggNOG; ENOG502SRT9; Eukaryota.
DR GeneTree; ENSGT00940000162923; -.
DR HOGENOM; CLU_051023_3_0_1; -.
DR InParanoid; Q496F6; -.
DR OMA; CRIQTVW; -.
DR OrthoDB; 1494510at2759; -.
DR PhylomeDB; Q496F6; -.
DR TreeFam; TF334441; -.
DR PathwayCommons; Q496F6; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-HSA-2172127; DAP12 interactions.
DR SignaLink; Q496F6; -.
DR BioGRID-ORCS; 342510; 6 hits in 586 CRISPR screens.
DR GenomeRNAi; 342510; -.
DR Pharos; Q496F6; Tbio.
DR PRO; PR:Q496F6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q496F6; protein.
DR Bgee; ENSG00000186407; Expressed in monocyte and 94 other tissues.
DR ExpressionAtlas; Q496F6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..205
FT /note="CMRF35-like molecule 2"
FT /id="PRO_0000320123"
FT TOPO_DOM 18..173
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 18..120
FT /note="Ig-like V-type"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 36..104
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 19
FT /note="K -> T (in dbSNP:rs581157)"
FT /evidence="ECO:0000269|PubMed:15557162"
FT /id="VAR_039129"
FT VARIANT 27
FT /note="T -> A (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs1278044712)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_039130"
FT VARIANT 158
FT /note="G -> R (in dbSNP:rs1878061)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_039131"
SQ SEQUENCE 205 AA; 22918 MW; 0486BEA4095A25D3 CRC64;
MWLLPALLLL CLSGCLSLKG PGSVTGTAGD SLTVWCQYES MYKGYNKYWC RGQYDTSCES
IVETKGEEKV ERNGRVSIRD HPEALAFTVT MQNLNEDDAG SYWCKIQTVW VLDSWSRDPS
DLVRVYVSPA ITTPRRTTHP ATPPIFLVVN PGRNLSTGEV LTQNSGFRLS SPHFLLVVLL
KLPLLLSMLG AVFWVNRPQW APPGR
