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CLM2_MOUSE
ID   CLM2_MOUSE              Reviewed;         196 AA.
AC   Q8K249;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=CMRF35-like molecule 2;
DE            Short=CLM-2;
DE   AltName: Full=CD300 antigen-like family member E;
DE   AltName: CD_antigen=CD300e;
DE   Flags: Precursor;
GN   Name=Cd300e; Synonyms=Cd300le, Clm2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=14662855; DOI=10.4049/jimmunol.171.12.6541;
RA   Chung D.-H., Humphrey M.B., Nakamura M.C., Ginzinger D.G., Seaman W.E.,
RA   Daws M.R.;
RT   "CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit
RT   osteoclast formation.";
RL   J. Immunol. 171:6541-6548(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Colonna M.;
RL   Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probably acts as an activating receptor. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TYROBP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CD300 family. {ECO:0000305}.
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DR   EMBL; AY457048; AAR27939.1; -; mRNA.
DR   EMBL; AF437879; AAN86136.1; -; mRNA.
DR   EMBL; AL607025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC034097; AAH34097.1; -; mRNA.
DR   EMBL; BC039971; AAH39971.1; -; mRNA.
DR   CCDS; CCDS25618.1; -.
DR   RefSeq; NP_742047.1; NM_172050.3.
DR   RefSeq; XP_006533136.1; XM_006533073.1.
DR   RefSeq; XP_006533137.1; XM_006533074.1.
DR   AlphaFoldDB; Q8K249; -.
DR   SMR; Q8K249; -.
DR   STRING; 10090.ENSMUSP00000054883; -.
DR   GlyGen; Q8K249; 1 site.
DR   PhosphoSitePlus; Q8K249; -.
DR   PaxDb; Q8K249; -.
DR   PRIDE; Q8K249; -.
DR   Antibodypedia; 2708; 300 antibodies from 28 providers.
DR   DNASU; 217306; -.
DR   Ensembl; ENSMUST00000062787; ENSMUSP00000054883; ENSMUSG00000048498.
DR   GeneID; 217306; -.
DR   KEGG; mmu:217306; -.
DR   UCSC; uc007mgk.1; mouse.
DR   CTD; 342510; -.
DR   MGI; MGI:2387602; Cd300e.
DR   VEuPathDB; HostDB:ENSMUSG00000048498; -.
DR   eggNOG; ENOG502SRT9; Eukaryota.
DR   GeneTree; ENSGT00940000162923; -.
DR   HOGENOM; CLU_051023_3_0_1; -.
DR   InParanoid; Q8K249; -.
DR   OMA; CRIQTVW; -.
DR   OrthoDB; 1494510at2759; -.
DR   PhylomeDB; Q8K249; -.
DR   TreeFam; TF334441; -.
DR   Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   Reactome; R-MMU-2172127; DAP12 interactions.
DR   BioGRID-ORCS; 217306; 2 hits in 71 CRISPR screens.
DR   ChiTaRS; Cyth2; mouse.
DR   PRO; PR:Q8K249; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8K249; protein.
DR   Bgee; ENSMUSG00000048498; Expressed in spleen and 20 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW   Immunoglobulin domain; Membrane; Receptor; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..196
FT                   /note="CMRF35-like molecule 2"
FT                   /id="PRO_0000320124"
FT   TOPO_DOM        18..171
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        193..196
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          18..122
FT                   /note="Ig-like V-type"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        36..104
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   196 AA;  21822 MW;  E23888479CB556E8 CRC64;
     MRLCAGLLLL CFQGCLSLTG PGSVSGYVGG SLRVQCQYSP SYKGYMKYWC RGPHDTTCKT
     IVETDGSEKE KRSGPVSIRD HASNSTITVI MEDLSEDNAG SYWCKIQTSF IWDSWSRDPS
     VSVRVNVFPA TTPTLPATTA ILPLVNSGQN LRISTNVMFI FQLWSLLSSI QFQVLVFLKL
     PLFLSMLCAI FWVNRL
 
 
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