CLM5_HUMAN
ID CLM5_HUMAN Reviewed; 194 AA.
AC Q6UXZ3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=CMRF35-like molecule 5 {ECO:0000250|UniProtKB:Q8VCH2};
DE Short=CLM-5 {ECO:0000250|UniProtKB:Q8VCH2};
DE AltName: Full=CD300 antigen-like family member D;
DE AltName: Full=CMRF35-A4;
DE AltName: CD_antigen=CD300d;
DE Flags: Precursor;
GN Name=CD300LD;
GN Synonyms=CD300D {ECO:0000303|PubMed:22291008, ECO:0000303|Ref.1},
GN CMRF35A4 {ECO:0000303|PubMed:12483297}; ORFNames=UNQ9218/PRO28686;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Martinez-Barriocanal A., Sayos J.;
RT "Molecular and functional characterization of human CD300d, a novel
RT receptor expressed by myeloid cells.";
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, SUBUNIT, TISSUE
RP SPECIFICITY, GLYCOSYLATION, AND MUTAGENESIS OF ARG-158.
RC TISSUE=Peripheral blood monocyte;
RX PubMed=22291008; DOI=10.1074/jbc.m111.279224;
RA Comas-Casellas E., Martinez-Barriocanal A., Miro F., Ejarque-Ortiz A.,
RA Schwartz S. Jr., Martin M., Sayos J.;
RT "Cloning and characterization of CD300d, a novel member of the human CD300
RT family of immune receptors.";
RL J. Biol. Chem. 287:9682-9693(2012).
RN [4]
RP IDENTIFICATION.
RX PubMed=12483297; DOI=10.1007/s00439-002-0851-y;
RA Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L.,
RA Taillon-Miller P., Kwok P.Y., Menter A., Bowcock A.M.;
RT "Novel immunoglobulin superfamily gene cluster, mapping to a region of
RT human chromosome 17q25, linked to psoriasis susceptibility.";
RL Hum. Genet. 112:34-41(2003).
CC -!- SUBUNIT: Forms complexes with the CD300 family members with exception
CC of CD300c. {ECO:0000269|PubMed:22291008}.
CC -!- INTERACTION:
CC Q6UXZ3; A8K4G0: CD300LB; NbExp=2; IntAct=EBI-4314468, EBI-26499879;
CC Q6UXZ3; P04155: TFF1; NbExp=3; IntAct=EBI-4314468, EBI-743871;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22291008};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:22291008}.
CC Note=Cell surface localization requires the ITAM-bearing Fc receptor
CC FCER1G to overcome ER retention.
CC -!- TISSUE SPECIFICITY: Expression seems restricted to cells of myeloid
CC lineage. {ECO:0000269|PubMed:22291008}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:22291008}.
CC -!- SIMILARITY: Belongs to the CD300 family. {ECO:0000305}.
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DR EMBL; EF137868; ABM30606.1; -; mRNA.
DR EMBL; AY358148; AAQ88515.1; -; mRNA.
DR CCDS; CCDS42379.1; -.
DR RefSeq; NP_001108624.1; NM_001115152.1.
DR AlphaFoldDB; Q6UXZ3; -.
DR SMR; Q6UXZ3; -.
DR BioGRID; 137769; 2.
DR IntAct; Q6UXZ3; 8.
DR STRING; 9606.ENSP00000364501; -.
DR GlyGen; Q6UXZ3; 1 site.
DR iPTMnet; Q6UXZ3; -.
DR PhosphoSitePlus; Q6UXZ3; -.
DR BioMuta; CD300LD; -.
DR DMDM; 74758584; -.
DR jPOST; Q6UXZ3; -.
DR MassIVE; Q6UXZ3; -.
DR PaxDb; Q6UXZ3; -.
DR PeptideAtlas; Q6UXZ3; -.
DR PRIDE; Q6UXZ3; -.
DR Antibodypedia; 31991; 32 antibodies from 16 providers.
DR DNASU; 100131439; -.
DR Ensembl; ENST00000375352.1; ENSP00000364501.1; ENSG00000204345.1.
DR GeneID; 100131439; -.
DR KEGG; hsa:100131439; -.
DR MANE-Select; ENST00000375352.1; ENSP00000364501.1; NM_001115152.2; NP_001108624.1.
DR UCSC; uc002jkz.3; human.
DR CTD; 100131439; -.
DR GeneCards; CD300LD; -.
DR HGNC; HGNC:16848; CD300LD.
DR HPA; ENSG00000204345; Not detected.
DR MIM; 616301; gene.
DR neXtProt; NX_Q6UXZ3; -.
DR OpenTargets; ENSG00000204345; -.
DR PharmGKB; PA162382124; -.
DR VEuPathDB; HostDB:ENSG00000204345; -.
DR eggNOG; ENOG502SU7J; Eukaryota.
DR GeneTree; ENSGT00940000164782; -.
DR HOGENOM; CLU_051023_3_1_1; -.
DR InParanoid; Q6UXZ3; -.
DR OMA; NGLEWGS; -.
DR OrthoDB; 1494510at2759; -.
DR PhylomeDB; Q6UXZ3; -.
DR TreeFam; TF334441; -.
DR PathwayCommons; Q6UXZ3; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR SignaLink; Q6UXZ3; -.
DR BioGRID-ORCS; 100131439; 13 hits in 1067 CRISPR screens.
DR GenomeRNAi; 100131439; -.
DR Pharos; Q6UXZ3; Tdark.
DR PRO; PR:Q6UXZ3; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6UXZ3; protein.
DR Bgee; ENSG00000204345; Expressed in blood and 8 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..194
FT /note="CMRF35-like molecule 5"
FT /id="PRO_0000320126"
FT TOPO_DOM 19..165
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..194
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 19..125
FT /note="Ig-like V-type"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 39..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 6
FT /note="S -> A (in dbSNP:rs493430)"
FT /id="VAR_059386"
FT VARIANT 89
FT /note="V -> M (in dbSNP:rs783239)"
FT /id="VAR_059387"
FT MUTAGEN 158
FT /note="R->S: Unable to reach the cell surface upon
FT transfection."
FT /evidence="ECO:0000269|PubMed:22291008"
SQ SEQUENCE 194 AA; 21558 MW; 5E3A4CB03B473E12 CRC64;
MWLSPSLLLL ILPGYSIAAK ITGPTTVNGS EQGSLTVQCA YGSGWETYLK WRCQGADWNY
CNILVKTNGS EQEVKKNRVS IRDNQKNHVF TVTMENLKRD DADSYWCGTE RPGIDLGVKV
QVTINPGTQT AVSEWTTTTA SLAFTAAATQ KTSSPLTRSP LKSTHFLFLF LLELPLLLSM
LGTVLWVNRP QRRS
