CLM6_HUMAN
ID CLM6_HUMAN Reviewed; 224 AA.
AC Q08708;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=CMRF35-like molecule 6;
DE Short=CLM-6;
DE AltName: Full=CD300 antigen-like family member C;
DE AltName: Full=CMRF35-A1;
DE Short=CMRF-35;
DE AltName: Full=Immunoglobulin superfamily member 16;
DE Short=IgSF16;
DE AltName: CD_antigen=CD300c;
DE Flags: Precursor;
GN Name=CD300C; Synonyms=CMRF35, CMRF35A, CMRF35A1, IGSF16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1349532; DOI=10.1002/eji.1830220508;
RA Jackson D.G., Hart D.N.J., Starling G., Bell J.I.;
RT "Molecular cloning of a novel member of the immunoglobulin gene superfamily
RT homologous to the polymeric immunoglobulin receptor.";
RL Eur. J. Immunol. 22:1157-1163(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11556966; DOI=10.1034/j.1399-0039.2001.057005415.x;
RA Clark G.J., Cooper B., Fitzpatrick S., Green B.J., Hart D.N.;
RT "The gene encoding the immunoregulatory signaling molecule CMRF-35A
RT localized to human chromosome 17 in close proximity to other members of the
RT CMRF-35 family.";
RL Tissue Antigens 57:415-423(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=12483297; DOI=10.1007/s00439-002-0851-y;
RA Speckman R.A., Wright Daw J.A., Helms C., Duan S., Cao L.,
RA Taillon-Miller P., Kwok P.Y., Menter A., Bowcock A.M.;
RT "Novel immunoglobulin superfamily gene cluster, mapping to a region of
RT human chromosome 17q25, linked to psoriasis susceptibility.";
RL Hum. Genet. 112:34-41(2003).
CC -!- INTERACTION:
CC Q08708; A8K4G0: CD300LB; NbExp=4; IntAct=EBI-3915344, EBI-26499879;
CC Q08708; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-3915344, EBI-18938272;
CC Q08708; P30273: FCER1G; NbExp=2; IntAct=EBI-3915344, EBI-515289;
CC Q08708; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-3915344, EBI-11955647;
CC Q08708; O15529: GPR42; NbExp=3; IntAct=EBI-3915344, EBI-18076404;
CC Q08708; O95214: LEPROTL1; NbExp=3; IntAct=EBI-3915344, EBI-750776;
CC Q08708; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-3915344, EBI-17684533;
CC Q08708; Q86WB7-2: UNC93A; NbExp=3; IntAct=EBI-3915344, EBI-13356252;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Present on the surface of monocytes, neutrophils, a
CC proportion of peripheral blood T- and B-lymphocytes and lymphocytic
CC cell lines.
CC -!- SIMILARITY: Belongs to the CD300 family. {ECO:0000305}.
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DR EMBL; X66171; CAA46948.1; -; mRNA.
DR EMBL; AF373866; AAK64272.1; -; Genomic_DNA.
DR EMBL; AF373863; AAK64272.1; JOINED; Genomic_DNA.
DR EMBL; AF373864; AAK64272.1; JOINED; Genomic_DNA.
DR EMBL; AF373865; AAK64272.1; JOINED; Genomic_DNA.
DR EMBL; BC022279; AAH22279.1; -; mRNA.
DR CCDS; CCDS11701.1; -.
DR PIR; I37243; I37243.
DR RefSeq; NP_006669.1; NM_006678.4.
DR AlphaFoldDB; Q08708; -.
DR SMR; Q08708; -.
DR BioGRID; 116080; 14.
DR IntAct; Q08708; 18.
DR STRING; 9606.ENSP00000329507; -.
DR GlyGen; Q08708; 2 sites.
DR iPTMnet; Q08708; -.
DR PhosphoSitePlus; Q08708; -.
DR BioMuta; CD300C; -.
DR DMDM; 1705938; -.
DR MassIVE; Q08708; -.
DR PaxDb; Q08708; -.
DR PeptideAtlas; Q08708; -.
DR PRIDE; Q08708; -.
DR Antibodypedia; 3049; 305 antibodies from 30 providers.
DR DNASU; 10871; -.
DR Ensembl; ENST00000330793.2; ENSP00000329507.1; ENSG00000167850.4.
DR GeneID; 10871; -.
DR KEGG; hsa:10871; -.
DR MANE-Select; ENST00000330793.2; ENSP00000329507.1; NM_006678.5; NP_006669.1.
DR UCSC; uc002jky.3; human.
DR CTD; 10871; -.
DR DisGeNET; 10871; -.
DR GeneCards; CD300C; -.
DR HGNC; HGNC:19320; CD300C.
DR HPA; ENSG00000167850; Tissue enhanced (bone marrow, lung, lymphoid tissue).
DR MIM; 606786; gene.
DR neXtProt; NX_Q08708; -.
DR OpenTargets; ENSG00000167850; -.
DR PharmGKB; PA142672150; -.
DR VEuPathDB; HostDB:ENSG00000167850; -.
DR eggNOG; ENOG502S8BD; Eukaryota.
DR GeneTree; ENSGT00940000159622; -.
DR HOGENOM; CLU_051023_3_0_1; -.
DR InParanoid; Q08708; -.
DR OMA; RTLNKFW; -.
DR OrthoDB; 1494510at2759; -.
DR PhylomeDB; Q08708; -.
DR TreeFam; TF334441; -.
DR PathwayCommons; Q08708; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR SignaLink; Q08708; -.
DR BioGRID-ORCS; 10871; 14 hits in 1055 CRISPR screens.
DR GeneWiki; CD300C; -.
DR GenomeRNAi; 10871; -.
DR Pharos; Q08708; Tbio.
DR PRO; PR:Q08708; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q08708; protein.
DR Bgee; ENSG00000167850; Expressed in monocyte and 112 other tissues.
DR Genevisible; Q08708; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunity; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..224
FT /note="CMRF35-like molecule 6"
FT /id="PRO_0000014681"
FT TOPO_DOM 21..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..130
FT /note="Ig-like V-type"
FT REGION 136..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 43..110
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 57..65
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 71
FT /note="T -> I (in dbSNP:rs11870245)"
FT /id="VAR_039133"
SQ SEQUENCE 224 AA; 24830 MW; 60C88716D84600D2 CRC64;
MTARAWASWR SSALLLLLVP GYFPLSHPMT VAGPVGGSLS VQCRYEKEHR TLNKFWCRPP
QILRCDKIVE TKGSAGKRNG RVSIRDSPAN LSFTVTLENL TEEDAGTYWC GVDTPWLRDF
HDPIVEVEVS VFPAGTTTAS SPQSSMGTSG PPTKLPVHTW PSVTRKDSPE PSPHPGSLFS
NVRFLLLVLL ELPLLLSMLG AVLWVNRPQR SSRSRQNWPK GENQ
