CLM6_MOUSE
ID CLM6_MOUSE Reviewed; 229 AA.
AC A2A7V7; Q6SJQ2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=CMRF35-like molecule 6;
DE Short=CLM-6;
DE AltName: Full=CD300 antigen-like family member C;
DE AltName: CD_antigen=CD300c;
DE Flags: Precursor;
GN Name=Cd300c; Synonyms=Clm6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=14662855; DOI=10.4049/jimmunol.171.12.6541;
RA Chung D.-H., Humphrey M.B., Nakamura M.C., Ginzinger D.G., Seaman W.E.,
RA Daws M.R.;
RT "CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit
RT osteoclast formation.";
RL J. Immunol. 171:6541-6548(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CD300 family. {ECO:0000305}.
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DR EMBL; AY457052; AAR27943.1; -; mRNA.
DR EMBL; AL607025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_954695.1; NM_199225.1.
DR AlphaFoldDB; A2A7V7; -.
DR SMR; A2A7V7; -.
DR STRING; 10090.ENSMUSP00000090123; -.
DR GlyGen; A2A7V7; 2 sites.
DR PhosphoSitePlus; A2A7V7; -.
DR PaxDb; A2A7V7; -.
DR PRIDE; A2A7V7; -.
DR DNASU; 387565; -.
DR UCSC; uc007mgc.1; mouse.
DR MGI; MGI:3032626; Cd300c.
DR eggNOG; ENOG502S8BD; Eukaryota.
DR InParanoid; A2A7V7; -.
DR OrthoDB; 1107444at2759; -.
DR PhylomeDB; A2A7V7; -.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 387565; 1 hit in 19 CRISPR screens.
DR ChiTaRS; Cd300c; mouse.
DR PRO; PR:A2A7V7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; A2A7V7; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..229
FT /note="CMRF35-like molecule 6"
FT /id="PRO_0000320129"
FT TOPO_DOM 22..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 210..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 22..126
FT /note="Ig-like V-type"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 43..110
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 141
FT /note="F -> V (in Ref. 1; AAR27943)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 229 AA; 25336 MW; 856656FDC5589FD0 CRC64;
MNPRVIRLWL PSAVLLSLVP GHFPVRGPST VTGTVGESLS VSCQYEKKLK TKKKIWCKWK
SNVLCKDIVK TSASEEARNG RVSIRDHPDN LTFTVTLENL TLEDAGTYMC MVDIGFFYDA
YLQIDKSFKV EVFVVPGKPP FKGSRPGNGI NILASPTSSA VHTQPNVTTD DTIPAPSPEL
RSLLSSPHFW ILVSLKLPLF LSMLGALLWV NRPQRCSGGS SAWPCYENQ
