CLP1_ASPCL
ID CLP1_ASPCL Reviewed; 560 AA.
AC A1CB93;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=mRNA cleavage and polyadenylation factor clp1 {ECO:0000255|HAMAP-Rule:MF_03035};
GN Name=clp1; ORFNames=ACLA_014480;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SUBUNIT: Component of a pre-mRNA cleavage factor complex. Interacts
CC directly with PCF11. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- CAUTION: May lack the polyribonucleotide 5'-hydroxyl-kinase and
CC polynucleotide 5'-hydroxyl-kinase activities that are characteristic of
CC the human ortholog. {ECO:0000305}.
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DR EMBL; DS027049; EAW13011.1; -; Genomic_DNA.
DR RefSeq; XP_001274437.1; XM_001274436.1.
DR AlphaFoldDB; A1CB93; -.
DR SMR; A1CB93; -.
DR STRING; 5057.CADACLAP00001249; -.
DR EnsemblFungi; EAW13011; EAW13011; ACLA_014480.
DR GeneID; 4706108; -.
DR KEGG; act:ACLA_014480; -.
DR VEuPathDB; FungiDB:ACLA_014480; -.
DR eggNOG; KOG2749; Eukaryota.
DR HOGENOM; CLU_018195_3_1_1; -.
DR OMA; VQYVNCH; -.
DR OrthoDB; 814241at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.30.330; -; 1.
DR Gene3D; 2.60.120.1030; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03035; Clp1; 1.
DR InterPro; IPR028606; Clp1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..560
FT /note="mRNA cleavage and polyadenylation factor clp1"
FT /id="PRO_0000375192"
FT REGION 416..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 71
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 159..164
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ SEQUENCE 560 AA; 58706 MW; 9DF07AFC11DBDE6D CRC64;
MSLPGLELSQ TSAEREFVSA PPTQISLSKG SEWRFEVAFG TAIRVKLLSG TAELFGTELA
ASQTYAFSGT KAAIYTWHGC TLEVGAGDTI STIDGLGSAG MNGGAVRGYG AGGCQSEYTA
EETPMVEYAN VHFALEAMRQ EAKATGKDGP RVLILGPENA GKTSLAKILT AYATKVGRQP
IVVNLDPAEG MLSVPGSLTA TAFRTMMNVE EGWGSSPMSG PSAIPVKLPL VYFYPLQNPL
EAGASVYRPI VSRLALSVTG RMAEDEDTRE TGIIVDTPGI LSQGKAGSLE VINHIVTEFA
INTILVIGSE RLYSTMMRSY DNKPTASASA AASDERITVV KLSKSGGCVD RDAAFMKAVR
ESQIRTYFFG NPIPSTASAA LSASASSTTN VTLSPHAQQL DFDSLAVYNY TISLPDEDED
EYDPSQLGTG DTFIPGGSNE AERAEPQQAE DSSFTPSMPG LAGSSGEDAT SAANSAVPLK
KVPRPAPTVL ANSLLAITHA APSAPSSEIR DASIMGFLYV ADVDSEKGKI RVLAPIGGRV
PPRAIVWGKK WPGEVVGLVG
