CLP1_CAEEL
ID CLP1_CAEEL Reviewed; 428 AA.
AC P52874;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein clpf-1 {ECO:0000255|HAMAP-Rule:MF_03035};
GN Name=clpf-1 {ECO:0000255|HAMAP-Rule:MF_03035}; ORFNames=F59A2.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR EMBL; Z34801; CAA84329.1; -; Genomic_DNA.
DR PIR; T22973; T22973.
DR RefSeq; NP_001040858.1; NM_001047393.2.
DR PDB; 4OHV; X-ray; 2.30 A; A=1-428.
DR PDB; 4OHW; X-ray; 2.30 A; A=1-428.
DR PDB; 4OHX; X-ray; 1.98 A; A=1-428.
DR PDB; 4OHY; X-ray; 2.00 A; A=1-428.
DR PDB; 4OHZ; X-ray; 2.40 A; A=1-428.
DR PDB; 4OI0; X-ray; 2.20 A; A=1-428.
DR PDB; 4OI1; X-ray; 2.30 A; A=1-428.
DR PDB; 4OI2; X-ray; 2.60 A; A=1-428.
DR PDBsum; 4OHV; -.
DR PDBsum; 4OHW; -.
DR PDBsum; 4OHX; -.
DR PDBsum; 4OHY; -.
DR PDBsum; 4OHZ; -.
DR PDBsum; 4OI0; -.
DR PDBsum; 4OI1; -.
DR PDBsum; 4OI2; -.
DR AlphaFoldDB; P52874; -.
DR SMR; P52874; -.
DR BioGRID; 40684; 8.
DR DIP; DIP-27405N; -.
DR IntAct; P52874; 3.
DR STRING; 6239.F59A2.4a; -.
DR EPD; P52874; -.
DR PaxDb; P52874; -.
DR PeptideAtlas; P52874; -.
DR EnsemblMetazoa; F59A2.4a.1; F59A2.4a.1; WBGene00010304.
DR GeneID; 175442; -.
DR KEGG; cel:CELE_F59A2.4; -.
DR UCSC; F59A2.4a; c. elegans.
DR CTD; 175442; -.
DR WormBase; F59A2.4a; CE17941; WBGene00010304; clpf-1.
DR eggNOG; KOG2749; Eukaryota.
DR HOGENOM; CLU_018195_1_0_1; -.
DR InParanoid; P52874; -.
DR OMA; VQYVNCH; -.
DR OrthoDB; 814241at2759; -.
DR PhylomeDB; P52874; -.
DR BRENDA; 2.7.1.78; 1045.
DR Reactome; R-CEL-72163; mRNA Splicing - Major Pathway.
DR Reactome; R-CEL-72187; mRNA 3'-end processing.
DR Reactome; R-CEL-73856; RNA Polymerase II Transcription Termination.
DR Reactome; R-CEL-77595; Processing of Intronless Pre-mRNAs.
DR PRO; PR:P52874; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00010304; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; P52874; baseline and differential.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IBA:GO_Central.
DR GO; GO:0051736; F:polyribonucleotide 5'-hydroxyl-kinase activity; IDA:WormBase.
DR GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR GO; GO:0046939; P:nucleotide phosphorylation; IDA:WormBase.
DR GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IBA:GO_Central.
DR Gene3D; 2.40.30.330; -; 1.
DR Gene3D; 2.60.120.1030; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03035; Clp1; 1.
DR InterPro; IPR028606; Clp1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..428
FT /note="Protein clpf-1"
FT /id="PRO_0000065378"
FT BINDING 16
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 56
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 124..129
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT STRAND 6..11
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 15..21
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 23..25
FT /evidence="ECO:0007829|PDB:4OHY"
FT STRAND 27..34
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 48..51
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 56..63
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 65..71
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 73..80
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 84..103
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 116..120
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 122..126
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 127..140
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 146..149
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 152..154
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 156..158
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 162..167
FT /evidence="ECO:0007829|PDB:4OHX"
FT TURN 174..176
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 184..187
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 190..192
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 193..195
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 197..214
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 215..217
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 219..224
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 226..229
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 237..248
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 252..258
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 260..267
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 274..279
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 290..306
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 309..312
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 316..321
FT /evidence="ECO:0007829|PDB:4OHX"
FT TURN 322..324
FT /evidence="ECO:0007829|PDB:4OHY"
FT STRAND 326..330
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 353..355
FT /evidence="ECO:0007829|PDB:4OHX"
FT HELIX 360..362
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 365..376
FT /evidence="ECO:0007829|PDB:4OHX"
FT TURN 377..381
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 384..394
FT /evidence="ECO:0007829|PDB:4OHX"
FT TURN 395..398
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 399..408
FT /evidence="ECO:0007829|PDB:4OHX"
FT STRAND 412..420
FT /evidence="ECO:0007829|PDB:4OHX"
SQ SEQUENCE 428 AA; 47598 MW; 9E6094897876AA92 CRC64;
MSEENVQEFV LKEDCELRFA AGDDSDVCLE LVKGYAEIFG TELLLNKKYT FPAKSRVAAF
TWKGATIELV GTTESAYVAE STPMVIYLNI HAAMEEVRKK REEQAAGNSN KAKGPRLLLV
GPTDVGKTTV SRILCNYSVR QGRTPIFVEL DVGQNSVSVP GTVAAVLVQK TADVIDGFER
NQPIVFNFGH TSPSANLSLY EALFKEMATT LNAQIQENDE AKIGGMIINT CGWVDGEGYK
CIVKAASAFE VDVVIVLDHE RLYSDLSKEL PEFVRLTHVP KSGGVEQRTG QIRSKMRGEN
VHRYFYGTRA NNLYPFTFDV SFDDVTLCKI GAEQLPDSCL PFGMEVENHE TKLVIMEPSA
DIKHHLFAFS RSTKADENVL KSPVFGFCLV TEVDLEKRTM SILCPQRTIP SKVLVFSDIT
HLDDQIKR
