CLP1_DROAN
ID CLP1_DROAN Reviewed; 425 AA.
AC B3MGZ0;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein CLP1 homolog {ECO:0000255|HAMAP-Rule:MF_03035};
GN Name=cbc; ORFNames=GF11182;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR EMBL; CH902619; EDV37908.1; -; Genomic_DNA.
DR RefSeq; XP_001961086.1; XM_001961050.2.
DR AlphaFoldDB; B3MGZ0; -.
DR SMR; B3MGZ0; -.
DR STRING; 7217.FBpp0114374; -.
DR EnsemblMetazoa; FBtr0115882; FBpp0114374; FBgn0088222.
DR GeneID; 6494046; -.
DR KEGG; dan:6494046; -.
DR eggNOG; KOG2749; Eukaryota.
DR HOGENOM; CLU_018195_1_0_1; -.
DR InParanoid; B3MGZ0; -.
DR OMA; VQYVNCH; -.
DR OrthoDB; 814241at2759; -.
DR PhylomeDB; B3MGZ0; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR GO; GO:0000214; C:tRNA-intron endonuclease complex; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:EnsemblMetazoa.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR Gene3D; 2.40.30.330; -; 1.
DR Gene3D; 2.60.120.1030; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03035; Clp1; 1.
DR InterPro; IPR028606; Clp1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..425
FT /note="Protein CLP1 homolog"
FT /id="PRO_0000375177"
FT BINDING 18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 59
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 121..126
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ SEQUENCE 425 AA; 46939 MW; 0B71E7C6C93D65B3 CRC64;
MSEELSHGKD YTLESDSELR FEIEQKDAKV LVTLISGFAE LFGTELVKKK KYEFGVGAKV
AIFTYQGCVL HVSGKMDVCY ISKETPMVQY LNCHAALEQF RTDAEDKDQR GPVAMVVGPM
DVGKSTLCRI LLNYAVRVGR RPLYADLDVG QGAIAISGNV ATILIERPAS VEDGFPKTAP
LVYHFGHKSP GGNSVLYNSV VSKMAEVTLQ SLNSNKRTKS SGIIINTCGW VKGSGYAHLL
HAAQAYGACA IFVLDQERLY NELLRDVPQG VNVVLLPKSG GVVERSKELR HESRDLRMKE
YFYGNPRAPF YPFSFEVKFQ DLRLYKIGAP PLPDSCMPIG MKAEDNKTKV VAVTPTPALI
HHILALSFAE SVEDDVIGSN VAGFCCVTEV DMERQAVMVL SPQPRPLPPN SLLLWSELQF
MDNHT
