CLP1_DROGR
ID CLP1_DROGR Reviewed; 425 AA.
AC B4JVN0;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Protein CLP1 homolog {ECO:0000255|HAMAP-Rule:MF_03035};
GN Name=cbc; ORFNames=GH23151;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR EMBL; CH916375; EDV98498.1; -; Genomic_DNA.
DR RefSeq; XP_001995426.1; XM_001995390.1.
DR AlphaFoldDB; B4JVN0; -.
DR SMR; B4JVN0; -.
DR STRING; 7222.FBpp0157057; -.
DR EnsemblMetazoa; FBtr0158565; FBpp0157057; FBgn0130608.
DR GeneID; 6568947; -.
DR KEGG; dgr:6568947; -.
DR eggNOG; KOG2749; Eukaryota.
DR HOGENOM; CLU_018195_1_0_1; -.
DR InParanoid; B4JVN0; -.
DR OMA; VQYVNCH; -.
DR OrthoDB; 814241at2759; -.
DR PhylomeDB; B4JVN0; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR GO; GO:0000214; C:tRNA-intron endonuclease complex; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR Gene3D; 2.40.30.330; -; 1.
DR Gene3D; 2.60.120.1030; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03035; Clp1; 1.
DR InterPro; IPR028606; Clp1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..425
FT /note="Protein CLP1 homolog"
FT /id="PRO_0000375179"
FT BINDING 18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 59
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 121..126
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ SEQUENCE 425 AA; 47215 MW; F511D2586AB88F9F CRC64;
MSEDNSQGRE YTLEADSELR FEIEQKNAKV LVTLLTGFAE LFGTELVKKK KYEFGVGAKV
AIFTYQGCVI HVSGQMDVCY ISKETPMVQY INCHAALEQF RLEAEQRDKR GPSVLIVGPM
DVGKSTLCRI LLNYAVRVGR RPLYADLDVG QGAISVAGNV ATILIERPAS IEDGFAKTAP
LVYHFGHKSP SGNSVLYNAV VSKMAEVTLQ SLDANKRTKS SGIIVNTCGW VKGSGYEHLL
HAARAYRARA IFVLDQERLY NDLLRDVPAN VHVVLLPKSG GVVERSKGLR HESREQRIKE
YFYGNARTPF YPFSFEVKFQ DLRLYKIGAP PLPDSCMPIG MKAEDNKKKV VAVTATPALL
HHILTLSFAE STDDDVIGTN IAGFCCVTEV DMERQSVMLL SPQPRPLPPN ALLLWSELQF
MDNHA
