CLP1_DROMO
ID CLP1_DROMO Reviewed; 425 AA.
AC B4KML2;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein CLP1 homolog {ECO:0000255|HAMAP-Rule:MF_03035};
GN Name=cbc; ORFNames=GI21336;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR EMBL; CH933808; EDW10859.1; -; Genomic_DNA.
DR RefSeq; XP_002006924.1; XM_002006888.2.
DR AlphaFoldDB; B4KML2; -.
DR SMR; B4KML2; -.
DR STRING; 7230.FBpp0170553; -.
DR EnsemblMetazoa; FBtr0172061; FBpp0170553; FBgn0144066.
DR GeneID; 6581179; -.
DR KEGG; dmo:Dmoj_GI21336; -.
DR eggNOG; KOG2749; Eukaryota.
DR HOGENOM; CLU_018195_1_0_1; -.
DR InParanoid; B4KML2; -.
DR OMA; VQYVNCH; -.
DR OrthoDB; 814241at2759; -.
DR PhylomeDB; B4KML2; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR GO; GO:0000214; C:tRNA-intron endonuclease complex; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:EnsemblMetazoa.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR Gene3D; 2.40.30.330; -; 1.
DR Gene3D; 2.60.120.1030; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03035; Clp1; 1.
DR InterPro; IPR028606; Clp1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..425
FT /note="Protein CLP1 homolog"
FT /id="PRO_0000375181"
FT BINDING 18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 59
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 121..126
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ SEQUENCE 425 AA; 47543 MW; 0370D9B5EE80A6CB CRC64;
MSEDNNNGKE YILDADSELR FEIEQKDAKV FVTLISGFAE LFGTELVKKK KYEFGIGAKV
AIFTYQGCVL QVTGKMDVCY ISKETPMIQY INCHAALEQF RTDAEEHDKR GPVILVVGPM
DVGKSTLCRI LLNYAVRVGR RPLYADLDVG QGAISIPGNI ATILIERPAS VEEGFAKTAP
LVYHFGHKSP SGNSVLYNAV VSKMAEVTLQ SLDANKRTKS SGIIVNTCGW VKGYGYKHLL
HAARAYRARA IFVLDQERLY NDLLRDVPSN VHVVLLPKSG GVVERTKELR HESREQRIKE
YFYGNMRTPF YPFSFEVKFQ DLRLYKIGAP PLPDSCMPIG MKAEDNKKKV VAVTPTSSLL
HHILTLSFAE STDENVIGTN VAGFCCVTEV DMERQSVMLL SPQPRPLPPN ALLLWSELQF
MDNHA
