CLP1_DROPE
ID CLP1_DROPE Reviewed; 425 AA.
AC B4GGT6;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Protein CLP1 homolog {ECO:0000255|HAMAP-Rule:MF_03035};
GN Name=cbc; ORFNames=GL17071;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR EMBL; CH479183; EDW35706.1; -; Genomic_DNA.
DR RefSeq; XP_002017867.1; XM_002017831.1.
DR AlphaFoldDB; B4GGT6; -.
DR SMR; B4GGT6; -.
DR STRING; 7234.FBpp0181178; -.
DR EnsemblMetazoa; FBtr0182686; FBpp0181178; FBgn0154675.
DR GeneID; 6592646; -.
DR KEGG; dpe:6592646; -.
DR eggNOG; KOG2749; Eukaryota.
DR HOGENOM; CLU_018195_1_0_1; -.
DR OMA; VQYVNCH; -.
DR PhylomeDB; B4GGT6; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR GO; GO:0000214; C:tRNA-intron endonuclease complex; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:EnsemblMetazoa.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR Gene3D; 2.40.30.330; -; 1.
DR Gene3D; 2.60.120.1030; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03035; Clp1; 1.
DR InterPro; IPR028606; Clp1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..425
FT /note="Protein CLP1 homolog"
FT /id="PRO_0000375182"
FT BINDING 18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 59
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 121..126
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ SEQUENCE 425 AA; 47093 MW; 7968DB628D9C67A2 CRC64;
MSDHQSRGQD FSLEADSELR FEIEQKDAKV LVTLVNGFAE LFGTELVKKK KYEFGMGAKV
AIFTYQGCVL HVTGKMDVCY ISKETPMVQY VNCHAALEQF RTEAEEKDRR GPVAMVVGPT
DVGKSTLCRI LLNYAVRVGR RPLYADLDVG QGAIAISGNV ATILIERPAS VEEGFPKTAP
LVYHFGHKSP SGNSVLYNAV VSKMAEVTLQ SLNGNKRTKS SGIIVNTCGW VKGHGYAHLL
HAARAYGACA IFVLDQERLY NELLRDVPSS VHVVLLPKSG GVVERSKELR HECRDQRIKE
YFYGNARAPF YPFSFEVKFQ ELRLYKIGAP PLPDSCMPIG MKAEDNKTKV VAVTPTPALI
HHVLALSFAE SVDDDVIGTN IAGFCCVTEV DMERQVVMLL SPQPRPLPPN ALLLWSELQF
MDNHT
