ID   CLP1_DROPS              Reviewed;         425 AA.
AC   Q28ZT4;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein CLP1 homolog {ECO:0000255|HAMAP-Rule:MF_03035};
GN   Name=cbc; ORFNames=GA19268;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC       dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC   -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR   EMBL; CM000071; EAL25529.1; -; Genomic_DNA.
DR   RefSeq; XP_001360953.1; XM_001360916.2.
DR   AlphaFoldDB; Q28ZT4; -.
DR   SMR; Q28ZT4; -.
DR   STRING; 7237.FBpp0276539; -.
DR   EnsemblMetazoa; FBtr0278101; FBpp0276539; FBgn0079265.
DR   GeneID; 4804382; -.
DR   KEGG; dpo:Dpse_GA19268; -.
DR   eggNOG; KOG2749; Eukaryota.
DR   HOGENOM; CLU_018195_1_0_1; -.
DR   InParanoid; Q28ZT4; -.
DR   OMA; VQYVNCH; -.
DR   PhylomeDB; Q28ZT4; -.
DR   Proteomes; UP000001819; Chromosome 3.
DR   Bgee; FBgn0079265; Expressed in male reproductive system and 3 other tissues.
DR   GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR   GO; GO:0000214; C:tRNA-intron endonuclease complex; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR   GO; GO:0043484; P:regulation of RNA splicing; IEA:EnsemblMetazoa.
DR   GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR   Gene3D; 2.40.30.330; -; 1.
DR   Gene3D; 2.60.120.1030; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_03035; Clp1; 1.
DR   InterPro; IPR028606; Clp1.
DR   InterPro; IPR045116; Clp1/Grc3.
DR   InterPro; IPR010655; Clp1_C.
DR   InterPro; IPR038238; Clp1_C_sf.
DR   InterPro; IPR032324; Clp1_N.
DR   InterPro; IPR038239; Clp1_N_sf.
DR   InterPro; IPR032319; CLP1_P.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR12755; PTHR12755; 1.
DR   Pfam; PF06807; Clp1; 1.
DR   Pfam; PF16573; CLP1_N; 1.
DR   Pfam; PF16575; CLP1_P; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..425
FT                   /note="Protein CLP1 homolog"
FT                   /id="PRO_0000375183"
FT   BINDING         18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT   BINDING         59
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT   BINDING         121..126
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ   SEQUENCE   425 AA;  47120 MW;  4E79E4A616472EAD CRC64;
     MSDHQNRGQD FSLEADSELR FEIEQKDAKV LVTLVNGFAE LFGTELVKKK KYEFGMGAKV
     AIFTYQGCVL HVTGKMDVCY ISKETPMVQY VNCHAALEQF RTEAEEKDRR GPVAMVVGPT
     DVGKSTLCRI LLNYAVRVGR RPLYADLDVG QGAIAISGNV ATILIERPAS VEEGFPKTAP
     LVYHFGHKSP SGNSVLYNAV VSKMAEVTLQ SLNGNKRTKS SGIIVNTCGW VKGHGYAHLL
     HAARAYGACA IFVLDQERLY NELLRDVPSS VHVVLLPKSG GVVERSKELR HECRDQRIKE
     YFYGNARAPF YPFSFEVKFQ ELRLYKIGAP PLPDSCMPIG MKAEDNKTKV VAVTPTPALI
     HHVLALSFAE SVDDDVIGTN IAGFCCVTEV DMERQVVMLL SPQPRPLPPN ALLLWSELQF
     MDNHT