CLP1_DROSI
ID CLP1_DROSI Reviewed; 423 AA.
AC B4QEE3;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Protein CLP1 homolog {ECO:0000255|HAMAP-Rule:MF_03035};
GN Name=cbc; ORFNames=GD25757;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03035}.
CC -!- SIMILARITY: Belongs to the Clp1 family. Clp1 subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_03035}.
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DR EMBL; CM000362; EDX06933.1; -; Genomic_DNA.
DR RefSeq; XP_002081348.1; XM_002081312.2.
DR AlphaFoldDB; B4QEE3; -.
DR SMR; B4QEE3; -.
DR STRING; 7240.B4QEE3; -.
DR EnsemblMetazoa; FBtr0225667; FBpp0224159; FBgn0197038.
DR GeneID; 6734325; -.
DR HOGENOM; CLU_018195_1_0_1; -.
DR OMA; VQYVNCH; -.
DR PhylomeDB; B4QEE3; -.
DR Proteomes; UP000000304; Chromosome 2r.
DR Bgee; FBgn0197038; Expressed in embryo and 3 other tissues.
DR GO; GO:0005849; C:mRNA cleavage factor complex; IEA:InterPro.
DR GO; GO:0000214; C:tRNA-intron endonuclease complex; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051731; F:polynucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:UniProtKB-UniRule.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:EnsemblMetazoa.
DR GO; GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; ISS:UniProtKB.
DR Gene3D; 2.40.30.330; -; 1.
DR Gene3D; 2.60.120.1030; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR HAMAP; MF_03035; Clp1; 1.
DR InterPro; IPR028606; Clp1.
DR InterPro; IPR045116; Clp1/Grc3.
DR InterPro; IPR010655; Clp1_C.
DR InterPro; IPR038238; Clp1_C_sf.
DR InterPro; IPR032324; Clp1_N.
DR InterPro; IPR038239; Clp1_N_sf.
DR InterPro; IPR032319; CLP1_P.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12755; PTHR12755; 1.
DR Pfam; PF06807; Clp1; 1.
DR Pfam; PF16573; CLP1_N; 1.
DR Pfam; PF16575; CLP1_P; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW ATP-binding; mRNA processing; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..423
FT /note="Protein CLP1 homolog"
FT /id="PRO_0000375185"
FT BINDING 16
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
FT BINDING 119..124
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03035"
SQ SEQUENCE 423 AA; 46800 MW; CAF87A3247866F8C CRC64;
MSEDHGKDYT LESDSELRFE IEQKDAKVLV SLVSGFAELF GTELVKKKQY EFGVGAKVAI
FTYQGCVLHV SGKMDVCYIS KETPMVQYVN CHAALEQFRM EAEEKDRYGP VAMVVGPMDV
GKSTLCRILL NYAVRVGRRP LYADLDVGQG SIAISGSVAT ILIERPANVE EGFAKTAPLV
YHFGHKSPSG NSVLYNAVVS KMAEVTLQSL NSNKRTKSSG IIINTCGWVK GSGYAHLLHA
AKAYGACAIF VLDQERLYNE LLRDVPKGVH VVLLPKSGGV VERSKELRHE ARDQRIKEYF
YGNTRAPFYP FSFEVKFQDL RLYKIGAPPL PDSCMPIGMK AEDNKTKVVA VTPTPALIHH
VLALSFAESV EDDVIGTNVA GFCCVTEVDM ERQAVMLLSP QPRPLPPNAL LLWSELQFMD
NHT
