CLPC_CHLPN
ID CLPC_CHLPN Reviewed; 845 AA.
AC Q9Z8A6; Q9JSE9; Q9K297;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Probable ATP-dependent Clp protease ATP-binding subunit;
GN Name=clpC; OrderedLocusNames=CPn_0437, CP_0316, CpB0454;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. ClpC subfamily.
CC {ECO:0000305}.
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DR EMBL; AE001363; AAD18581.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38172.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98645.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98384.1; -; Genomic_DNA.
DR PIR; C86545; C86545.
DR PIR; G72079; G72079.
DR PIR; G81590; G81590.
DR RefSeq; NP_224637.1; NC_000922.1.
DR RefSeq; WP_010892034.1; NZ_LN847221.1.
DR AlphaFoldDB; Q9Z8A6; -.
DR SMR; Q9Z8A6; -.
DR STRING; 115711.CP_0316; -.
DR PRIDE; Q9Z8A6; -.
DR EnsemblBacteria; AAD18581; AAD18581; CPn_0437.
DR EnsemblBacteria; AAF38172; AAF38172; CP_0316.
DR GeneID; 45050484; -.
DR KEGG; cpa:CP_0316; -.
DR KEGG; cpj:clpC; -.
DR KEGG; cpn:CPn_0437; -.
DR KEGG; cpt:CpB0454; -.
DR PATRIC; fig|115713.3.peg.484; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_2_0; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 1.10.1780.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF81923; SSF81923; 1.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chaperone; Nucleotide-binding; Repeat.
FT CHAIN 1..845
FT /note="Probable ATP-dependent Clp protease ATP-binding
FT subunit"
FT /id="PRO_0000191231"
FT DOMAIN 2..145
FT /note="Clp R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT DOMAIN 441..476
FT /note="UVR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00217"
FT REGION 5..70
FT /note="Repeat 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT REGION 81..145
FT /note="Repeat 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT REGION 149..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 232..239
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 569..576
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 4
FT /note="K -> T (in Ref. 3; BAA98645)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="K -> R (in Ref. 1; AAD18581)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 845 AA; 94981 MW; C9D9205458812866 CRC64;
MFEKFTNRAK QVIKLAKKEA QRLNHNYLGT EHILLGLLKL GQGVAVNVLR NLGIDFDTAR
QEVERLIGYG PEIQVYGDPA LTGRVKKSFE SANEEASLLE HNYVGTEHLL LGILHQSDSV
ALQVLENLHI DPREVRKEIL KELETFNLQL PPSSSSSSSS SRSNPSSSKS PLGHSLGSDK
NEKLSALKAY GYDLTEMVRE SKLDPVIGRS SEVERLILIL CRRRKNNPVL IGEAGVGKTA
IVEGLAQKII LNEVPDALRK KRLITLDLAL MIAGTKYRGQ FEERIKAVMD EVRKHGNILL
FIDELHTIVG AGAAEGAIDA SNILKPALAR GEIQCIGATT IDEYRKHIEK DAALERRFQK
IVVHPPSVDE TIEILRGLKK KYEEHHNVFI TEEALKAAAT LSDQYVHGRF LPDKAIDLLD
EAGARVRVNT MGQPTDLMKL EAEIENTKLA KEQAIGTQEY EKAAGLRDEE KKLRERLQSM
KQEWENHKEE HQVPVDEEAV AQVVSLQTGI PSARLTEAES EKLLKLEDTL RRKVIGQNDA
VTSICRAIRR SRTGIKDPNR PTGSFLFLGP TGVGKSLLAQ QIAIEMFGGE DALIQVDMSE
YMEKFAATKM MGSPPGYVGH EEGGHLTEQV RRRPYCVVLF DEIEKAHPDI MDLMLQILEQ
GRLTDSFGRK VDFRHAIIIM TSNLGADLIR KSGEIGFGLK SHMDYKVIQE KIEHAMKKHL
KPEFINRLDE SVIFRPLEKE SLSEIIHLEI NKLDSRLKNY QMALNIPDSV ISFLVTKGHS
PEMGARPLRR VIEQYLEDPL AELLLKESCR QEARKLRATL VENRVAFERE EEEQEAALPS
PHLES
