CLPC_MYCLE
ID CLPC_MYCLE Reviewed; 848 AA.
AC P24428;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Probable ATP-dependent Clp protease ATP-binding subunit;
GN Name=clpC; OrderedLocusNames=ML0235;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-649.
RX PubMed=2204033; DOI=10.1093/nar/18.16.4935;
RA Nath I., Laal S.;
RT "Nucleotide sequence and deduced amino acid sequence of Mycobacterium
RT leprae gene showing homology to bacterial atp operon.";
RL Nucleic Acids Res. 18:4935-4935(1990).
RN [3]
RP SEQUENCE REVISION.
RA Nath I.;
RL Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-97.
RX PubMed=1840579; DOI=10.1128/iai.59.11.4117-4124.1991;
RA Sela S., Thole J.E., Ottenhoff T.H., Clark-Curtiss J.E.;
RT "Identification of Mycobacterium leprae antigens from a cosmid library:
RT characterization of a 15-kilodalton antigen that is recognized by both the
RT humoral and cellular immune systems in leprosy patients.";
RL Infect. Immun. 59:4117-4124(1991).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. ClpC subfamily.
CC {ECO:0000305}.
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DR EMBL; AL583917; CAC29743.1; -; Genomic_DNA.
DR EMBL; X53488; CAA37573.1; -; Genomic_DNA.
DR EMBL; M67510; AAA25352.1; -; Genomic_DNA.
DR PIR; C86938; C86938.
DR PIR; S11163; S11163.
DR RefSeq; NP_301295.1; NC_002677.1.
DR RefSeq; WP_010907619.1; NC_002677.1.
DR AlphaFoldDB; P24428; -.
DR SMR; P24428; -.
DR STRING; 272631.ML0235; -.
DR EnsemblBacteria; CAC29743; CAC29743; CAC29743.
DR KEGG; mle:ML0235; -.
DR PATRIC; fig|272631.5.peg.368; -.
DR Leproma; ML0235; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_1_11; -.
DR OMA; ERMKAVM; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 1.10.1780.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF81923; SSF81923; 1.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chaperone; Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..848
FT /note="Probable ATP-dependent Clp protease ATP-binding
FT subunit"
FT /id="PRO_0000191235"
FT DOMAIN 2..144
FT /note="Clp R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT DOMAIN 425..460
FT /note="UVR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00217"
FT REGION 5..70
FT /note="Repeat 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT REGION 80..144
FT /note="Repeat 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT REGION 171..418
FT /note="I"
FT REGION 479..670
FT /note="II"
FT REGION 823..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 216..223
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 553..560
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 39
FT /note="H -> P (in Ref. 4; AAA25352)"
FT /evidence="ECO:0000305"
FT CONFLICT 648..649
FT /note="TD -> EF (in Ref. 2; CAA37573)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 848 AA; 94002 MW; 49B191759397B697 CRC64;
MFERFTDRAR RVVVLAQEEA RMLNHNYIGT EHILLGLIHE GEGVAAKSLD SLGISLEAVR
SQVEDIIGQG QQAPSGHIPF TPRAKKVLEL SLREALQLGH NYIGTEHILL GLIREGEGVA
AQVLVKLGAE LTRVRQQVIQ LLSGYQGKEA AEAGTGGRGG ESGSPSTSLV LDQFGRNLTA
AAMESKLDPV IGREKEIERV MQVLSRRTKN NPVLIGEPGV GKTAVVEGLA QAIVHGEVPE
TLKDKQLYTL DLGSLVAGSR YRGDFEERLK KVLKEINTRG DIILFIDELH TLVGAGAAEG
AIDAASILKP KLARGELQTI GATTLDEYRK YIEKDAALER RFQPVQVGEP TVEHTIEILK
GLRDRYEAHH RVSITDSAMV AAATLADRYI NDRFLPDKAI DLIDEAGARM RIRRMTAPPD
LREFDEKIAE ARREKESAID AQDFEKAASL RDREKQLVAQ RAEREKQWRS GDLDVIAEVD
DEQIAEVLGN WTGIPVFKLT EAETTRLLRM EEELHKRIIG QEDAVKAVSK AIRRTRAGLK
DPKRPSGSFI FAGPSGVGKT ELSKALANFL FGDDDALIQI DMGEFHDRFT ASRLFGAPPG
YVGYEEGGQL TEKVRRKPFS VVLFDEIEKA HQEIYNSLLQ VLEDGRLTDG QGRTVDFKNT
VLIFTSNLGT SDISKPVGLG FTQGSGENDY ERMKQKVNDE LKKHFRPEFL NRIDDIIVFH
QLSRDEIIRM VDLMISRVAN QLKVKDMTLE LTNKAKALLA KRGFDPVLGA RPLRRTIQRE
IEDQLSEKIL FEEVGPGQVV TVDVDNWDGE GPGEDVKFTF TGIRKPSTEP DLAKAGVHSA
GGPEPVEQ
