CLPC_STAHJ
ID CLPC_STAHJ Reviewed; 824 AA.
AC Q4L3I4;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=ATP-dependent Clp protease ATP-binding subunit ClpC;
GN Name=clpC; OrderedLocusNames=SH2484;
OS Staphylococcus haemolyticus (strain JCSC1435).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=279808;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCSC1435;
RX PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA Hiramatsu K.;
RT "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT extreme plasticity of its genome and the evolution of human-colonizing
RT staphylococcal species.";
RL J. Bacteriol. 187:7292-7308(2005).
CC -!- FUNCTION: Required for growth at high temperatures, probably by acting
CC as a chaperone during heat shock and targeting heat-denatured proteins
CC for degradation by ClpP. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. ClpC subfamily.
CC {ECO:0000305}.
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DR EMBL; AP006716; BAE05793.1; -; Genomic_DNA.
DR RefSeq; WP_011276736.1; NC_007168.1.
DR AlphaFoldDB; Q4L3I4; -.
DR SMR; Q4L3I4; -.
DR STRING; 279808.SH2484; -.
DR PRIDE; Q4L3I4; -.
DR EnsemblBacteria; BAE05793; BAE05793; SH2484.
DR KEGG; sha:SH2484; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_1_9; -.
DR OMA; SKMMQGE; -.
DR OrthoDB; 44062at2; -.
DR Proteomes; UP000000543; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 1.10.1780.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF81923; SSF81923; 1.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chaperone; Nucleotide-binding; Repeat; Stress response.
FT CHAIN 1..824
FT /note="ATP-dependent Clp protease ATP-binding subunit ClpC"
FT /id="PRO_0000269690"
FT DOMAIN 3..144
FT /note="Clp R"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT DOMAIN 417..452
FT /note="UVR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00217"
FT REGION 6..71
FT /note="Repeat 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT REGION 80..144
FT /note="Repeat 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01251"
FT REGION 163..410
FT /note="I"
FT REGION 471..662
FT /note="II"
FT BINDING 208..215
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 545..552
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 824 AA; 91612 MW; 49FF2DFB72777CF5 CRC64;
MLFGRLTERA QRVLAHAQEE AIRLNHSNIG TEHLLLGLMK EPEGIAAKVL ESFNITEDKV
IEEVEKLIGH GQDQTGTLHY TPRAKKVIEL SMDEARKLHH NFVGTEHILL GLIRENEGVA
ARVFANLDLN ITKARAQVVK ALGSPEMSNK NATANKSNNT PTLDGLARDL TVIAKDGTLD
PVVGRDKEIT RVIEVLSRRT KNNPVLIGEP GVGKTAIAEG LAQAIVNNEV PETLKGKRVM
SLDMGTVVAG TKYRGEFEER LKKVMEEIHQ AGNVILFIDE LHTLVGAGGA EGAIDASNIL
KPALARGELQ CIGATTLDEY RKNIEKDAAL ERRFQPIQVD EPTVEDTIAI LKGLRDRYEA
HHRINISDEA LEAAAKLSDC YVSDRFLPDK AIDLIDEASS KVRLKSHTTP NNLKEIEQEI
EKVKNEKDAA VHAQEFENAA NLRDKQTKLE KQYEDAKNEW KTTQGDQSTS LSKEDIGEVI
AGWTGIPLTK INETESDRLL NLEQTLHDRV IGQNDAVTSI SKAVRRARAG LKDPKRPIGS
FIFLGPTGVG KTELARALAE SMFGEEDAMI RVDMSEFMEK HAVSRLVGAP PGYVGHDEGG
QLTEKVRRKP YSVILFDEIE KAHPDVFNIL LQVLDDGHLT DTKGRQVDFR NTVIIMTSNV
GAQELQDQRF AGFGGGSEGH DYETIRKTMM KELKNSFRPE FLNRVDDIIV FHKLSKDELK
EIVTMMVNKL TQRLSEQDIN IVVTDKAKEK IAEEGYDPEY GARPLIRAIQ KTVEDNLSEL
ILDGNQIEGK EVVIDHDGDE FKYNINEKNN GISDEGNEVT ETEA