ID   CLPC_STRP6              Reviewed;         699 AA.
AC   Q5XCL7; P82565;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Probable ATP-dependent Clp protease ATP-binding subunit;
GN   Name=clpC; OrderedLocusNames=M6_Spy0711;
OS   Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=286636;
RN   [1] {ECO:0000312|EMBL:AAT86846.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-946 / MGAS10394;
RX   PubMed=15272401; DOI=10.1086/422697;
RA   Banks D.J., Porcella S.F., Barbian K.D., Beres S.B., Philips L.E.,
RA   Voyich J.M., DeLeo F.R., Martin J.M., Somerville G.A., Musser J.M.;
RT   "Progress toward characterization of the group A Streptococcus metagenome:
RT   complete genome sequence of a macrolide-resistant serotype M6 strain.";
RL   J. Infect. Dis. 190:727-738(2004).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 168-182; 223-237; 289-301 AND 517-546, AND MASS
RP   SPECTROMETRY.
RC   STRAIN=JRS4 / Serotype M6 {ECO:0000269|Ref.2};
RA   Hogan D.A., Du P., Stevenson T.I., Whitton M., Kilby G.W., Rogers J.,
RA   VanBogelen R.A.;
RT   "Two-dimensional gel electrophoresis map of Streptococcus pyogenes
RT   proteins.";
RL   Submitted (MAY-2000) to UniProtKB.
CC   -!- MASS SPECTROMETRY: Mass=77347.42; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.2};
CC   -!- SIMILARITY: Belongs to the ClpA/ClpB family. ClpC subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP000003; AAT86846.1; -; Genomic_DNA.
DR   RefSeq; WP_011184415.1; NC_006086.1.
DR   AlphaFoldDB; Q5XCL7; -.
DR   SMR; Q5XCL7; -.
DR   PRIDE; Q5XCL7; -.
DR   EnsemblBacteria; AAT86846; AAT86846; M6_Spy0711.
DR   KEGG; spa:M6_Spy0711; -.
DR   HOGENOM; CLU_005070_4_3_9; -.
DR   OMA; GRVIQEH; -.
DR   Proteomes; UP000001167; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR001270; ClpA/B.
DR   InterPro; IPR028299; ClpA/B_CS2.
DR   InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   Pfam; PF17871; AAA_lid_9; 1.
DR   Pfam; PF10431; ClpB_D2-small; 1.
DR   PRINTS; PR00300; CLPPROTEASEA.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00871; CLPAB_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Chaperone; Direct protein sequencing; Nucleotide-binding;
KW   Repeat.
FT   CHAIN           1..699
FT                   /note="Probable ATP-dependent Clp protease ATP-binding
FT                   subunit"
FT                   /id="PRO_0000259668"
FT   REGION          76..325
FT                   /note="I"
FT                   /evidence="ECO:0000250|UniProtKB:P0A522"
FT   REGION          380..570
FT                   /note="II"
FT                   /evidence="ECO:0000250|UniProtKB:P0A522"
FT   BINDING         121..128
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         452..459
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   699 AA;  77429 MW;  A176B8AACF6A8CD6 CRC64;
     MTHFSGKDPF VNMDDIFNQL MANMGGYRSE NPRYLVNGRE ITPEEFQHYR QTGQLPVATT
     KATNSQMLTP KADSVLTQLG TNLTQEARQG HLDPVIGRNK EIQDTAEILA RRTKNNPVLV
     GDAGVGKTAV IEGLAQAIVN GDVPAAIKNK EIVSIDISSL EAGTQYRGSF EETIQNLIQE
     VKEAGNIILF FDEIHQIVGA GATSSDSGSK GLADILKPAL SRGELTLIGA TTQDEYRNTI
     LKNAALARRF NEVKVNAPSA EDTFHILMGI RNLYEQHHHI TLPDNVLKAA VDYSIQYIPQ
     RSLPDKAIDL LDMTAAHLAA QHPVTDLKTL ETEIAKQKES QEKAVAKEDF EKALAAKTRI
     ETLQKQIEQH NQSQNVTATV NDIAESVERL TGIPVSNMRT NDLERLKGIS SRLKSHVIGQ
     DEAVAAVARA IRRNRAGFDD GNRPIGSFLF VGPTGVGKTE LAKQLALDLF GSKDAIIRLD
     MSEYNDRTAV SKLIGTTAGY VGYDDNNNTL TERVRRNPYA IVLLDEIEKA DPQIITLLLQ
     VLDDGRLTDG QGNTINFKNT VIIATSNAGF GQQDTETSES NIMDRIAPYF RPEFLNRFNS
     IIKFNHLQKE NLEEIVDLML AEVNQTTAKK GISLTIADDA KAHLIDLGYN HAMGARPLRR
     IIEQEIRDRI TDYYLDHPEV KKLQAILKEG QLVIRQNDQ