ID   CLPH_ONCVO              Reviewed;         378 AA.
AC   P37801;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Calponin homolog OV9M;
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7935620; DOI=10.1016/0166-6851(94)90122-8;
RA   Irvine M., Huima T., Prince A.M., Lustigman S.;
RT   "Identification and characterization of an Onchocerca volvulus cDNA clone
RT   encoding a highly immunogenic calponin-like protein.";
RL   Mol. Biochem. Parasitol. 65:135-146(1994).
CC   -!- FUNCTION: Could be involved in muscle contraction.
CC   -!- TISSUE SPECIFICITY: Found in the longitudinal muscles below the
CC       hypodermis.
CC   -!- DEVELOPMENTAL STAGE: Present in infective larvae and adult stages.
CC   -!- MISCELLANEOUS: There are apparently several forms of the native protein
CC       which appear to be expressed in a stage-specific manner.
CC   -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-22 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA20215.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U01099; AAA20215.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; P37801; -.
DR   STRING; 6282.P37801; -.
DR   HOGENOM; CLU_048343_1_0_1; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   InterPro; IPR000557; Calponin_repeat.
DR   Pfam; PF00402; Calponin; 6.
DR   PROSITE; PS01052; CALPONIN_1; 5.
DR   PROSITE; PS51122; CALPONIN_2; 7.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat.
FT   CHAIN           1..378
FT                   /note="Calponin homolog OV9M"
FT                   /id="PRO_0000204793"
FT   REPEAT          50..75
FT                   /note="Calponin-like 1"
FT   REPEAT          98..123
FT                   /note="Calponin-like 2"
FT   REPEAT          151..176
FT                   /note="Calponin-like 3"
FT   REPEAT          197..222
FT                   /note="Calponin-like 4"
FT   REPEAT          244..269
FT                   /note="Calponin-like 5"
FT   REPEAT          285..310
FT                   /note="Calponin-like 6"
FT   REPEAT          330..355
FT                   /note="Calponin-like 7"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..194
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..256
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   378 AA;  41852 MW;  565E891180BF591E CRC64;
     MPAQPAQENA QDADDAQANA TMETRVAGQG QPKRVGRWTL AQLRQTDGII PSQAGWNKGD
     SQKLMTNFGT PRNTQTRVKS ENLAEIPEEV LMRTHGEVRL QSGTNKFESQ RGMTGFGTGR
     DVCREGVHVN QAPSDLQPLD EEKIRLSDGI VRLQAGTNKY DSQKGMTGFG TARRETTKMT
     DSKHPDYDHE RPDQSEIPLQ AGTNKFASQK GMIGFGTSRR ETTKICDSAH PEYDPESSID
     SSTIPSQMGS NKYASQKGMT GFGQPRWEVL DPSISWQNRK SQGMVRLQSG TNRFASQQGM
     TGFGTPRNTT YEAEAGELPY EDMKKSETVI PSQAGWNRGD SQKGMTGFGA PRDVKGKHLK
     RIWELEYPEE AEASLDRL