CLPP_MARPO
ID CLPP_MARPO Reviewed; 203 AA.
AC P12208;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=ATP-dependent Clp protease proteolytic subunit {ECO:0000255|HAMAP-Rule:MF_00444};
DE EC=3.4.21.92 {ECO:0000255|HAMAP-Rule:MF_00444};
DE AltName: Full=Endopeptidase Clp {ECO:0000255|HAMAP-Rule:MF_00444};
GN Name=clpP {ECO:0000255|HAMAP-Rule:MF_00444};
OS Marchantia polymorpha (Liverwort) (Marchantia aquatica).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Marchantiophyta;
OC Marchantiopsida; Marchantiidae; Marchantiales; Marchantiaceae; Marchantia.
OX NCBI_TaxID=3197;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3199436; DOI=10.1016/0022-2836(88)90003-4;
RA Fukuzawa H., Kohchi T., Sano T., Shirai H., Umesono K., Inokuchi H.,
RA Ozeki H., Ohyama K.;
RT "Structure and organization of Marchantia polymorpha chloroplast genome.
RT III. Gene organization of the large single copy region from rbcL to
RT trnI(CAU).";
RL J. Mol. Biol. 203:333-351(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX DOI=10.1038/322572a0;
RA Ohyama K., Fukuzawa H., Kohchi T., Shirai H., Sano T., Sano S., Umesono K.,
RA Shiki Y., Takeuchi M., Chang Z., Aota S., Inokuchi H., Ozeki H.;
RT "Chloroplast gene organization deduced from complete sequence of liverwort
RT Marchantia polymorpha chloroplast DNA.";
RL Nature 322:572-574(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 184-203.
RA Fukuzawa H., Kohchi T., Shirai H., Ohyama K., Umesono K., Inokuchi H.,
RA Ozeki H.;
RT "Coding sequences for chloroplast ribosomal protein S12 from the liverwort,
RT Marchantia polymorpha, are separated far apart on the different DNA
RT strands.";
RL FEBS Lett. 198:11-15(1986).
CC -!- FUNCTION: Cleaves peptides in various proteins in a process that
CC requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a
CC major role in the degradation of misfolded proteins.
CC {ECO:0000255|HAMAP-Rule:MF_00444}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins to small peptides in the presence of
CC ATP and magnesium. alpha-casein is the usual test substrate. In the
CC absence of ATP, only oligopeptides shorter than five residues are
CC hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-
CC Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also
CC occurs).; EC=3.4.21.92; Evidence={ECO:0000255|HAMAP-Rule:MF_00444};
CC -!- SUBUNIT: Component of the chloroplastic Clp protease core complex.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast stroma {ECO:0000255|HAMAP-
CC Rule:MF_00444}.
CC -!- SIMILARITY: Belongs to the peptidase S14 family. {ECO:0000255|HAMAP-
CC Rule:MF_00444}.
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DR EMBL; X04465; CAA28109.1; -; Genomic_DNA.
DR EMBL; X03661; CAA27296.1; -; Genomic_DNA.
DR PIR; S01545; A05056.
DR RefSeq; NP_039323.1; NC_001319.1.
DR AlphaFoldDB; P12208; -.
DR SMR; P12208; -.
DR MEROPS; S14.002; -.
DR GeneID; 2702606; -.
DR BRENDA; 3.4.21.92; 3182.
DR GO; GO:0009534; C:chloroplast thylakoid; IEA:EnsemblPlants.
DR GO; GO:0009840; C:chloroplastic endopeptidase Clp complex; IEA:EnsemblPlants.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-UniRule.
DR CDD; cd07017; S14_ClpP_2; 1.
DR HAMAP; MF_00444; ClpP; 1.
DR InterPro; IPR001907; ClpP.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR023562; ClpP/TepA.
DR InterPro; IPR033135; ClpP_His_AS.
DR InterPro; IPR018215; ClpP_Ser_AS.
DR PANTHER; PTHR10381; PTHR10381; 1.
DR Pfam; PF00574; CLP_protease; 1.
DR PRINTS; PR00127; CLPPROTEASEP.
DR SUPFAM; SSF52096; SSF52096; 1.
DR PROSITE; PS00382; CLP_PROTEASE_HIS; 1.
DR PROSITE; PS00381; CLP_PROTEASE_SER; 1.
PE 3: Inferred from homology;
KW Chloroplast; Hydrolase; Plastid; Protease; Serine protease.
FT CHAIN 1..203
FT /note="ATP-dependent Clp protease proteolytic subunit"
FT /id="PRO_0000179744"
FT ACT_SITE 101
FT /note="Nucleophile"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00444"
FT ACT_SITE 126
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00444"
FT CONFLICT 184
FT /note="A -> E (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 203 AA; 22685 MW; C0C30114F13CB89B CRC64;
MPIGVPKVPF RLPGEEDAVW IDVYNRLYRE RLLFLGQQVD DEIANQLIGI MMYLNGEDES
KDMYLYINSP GGAVLAGISV YDAMQFVVPD VHTICMGLAA SMGSFILTGG EITKRIALPH
ARVMIHQPAS SYYDGQAGEC IMEAEEVLKL RDCITKVYVQ RTGKPLWVIS EDMERDVFMS
AKEAKLYGIV DLVAIENNST IKN