ID   2A5E_RABIT              Reviewed;         165 AA.
AC   Q28654;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform;
DE   AltName: Full=PP2A B subunit isoform B'-delta;
DE   AltName: Full=PP2A B subunit isoform B'-epsilon;
DE   AltName: Full=PP2A B subunit isoform B56-epsilon;
DE   AltName: Full=PP2A B subunit isoform PR61-epsilon;
DE   AltName: Full=PP2A B subunit isoform R5-epsilon;
DE   Flags: Fragment;
GN   Name=PPP2R5E;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand; TISSUE=Brain;
RX   PubMed=8576224; DOI=10.1074/jbc.271.5.2578;
RA   Csortos C., Zolnierowicz S., Bako E., Durbin S.D., Depaoli-Roach A.A.;
RT   "High complexity in the expression of the B' subunit of protein phosphatase
RT   2A0. Evidence for the existence of at least seven novel isoforms.";
RL   J. Biol. Chem. 271:2578-2588(1996).
CC   -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC       and catalytic activity, and also might direct the localization of the
CC       catalytic enzyme to a particular subcellular compartment.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. Proteins that associate with the core dimer
CC       include three families of regulatory subunits B (the R2/B/PR55/B55,
CC       R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC       regulatory subunit, viral proteins, and cell signaling molecules.
CC       Interacts with SGO1. Found in a complex with at least ARL2, PPP2CB;
CC       PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis, lung and brain.
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B56
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Nomenclature used in PubMed:8576224 refers to PP2A B subunit
CC       B' delta isoform, which is cited as PP2A B subunit epsilon-PR61 isoform
CC       in later publications. {ECO:0000305}.
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DR   EMBL; U38194; AAC48533.1; -; mRNA.
DR   AlphaFoldDB; Q28654; -.
DR   SMR; Q28654; -.
DR   STRING; 9986.ENSOCUP00000003063; -.
DR   eggNOG; KOG2085; Eukaryota.
DR   InParanoid; Q28654; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR002554; PP2A_B56.
DR   PANTHER; PTHR10257; PTHR10257; 1.
DR   Pfam; PF01603; B56; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q16537"
FT   CHAIN           2..>165
FT                   /note="Serine/threonine-protein phosphatase 2A 56 kDa
FT                   regulatory subunit epsilon isoform"
FT                   /id="PRO_0000071456"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16537"
FT   MOD_RES         7
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16537"
FT   MOD_RES         30
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16537"
FT   MOD_RES         32
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16537"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q16537"
FT   NON_TER         165
SQ   SEQUENCE   165 AA;  19048 MW;  6F4A6E32D0D85B7D CRC64;
     MSSAPTTPPS VDKVDGFSRK SVRKARQKRS QSSSQFRSQG KPIELTPLPL LKDVPSSEQP
     ELFLKKLQQC CVIFDFMDTL SDLKMKEYKR STLNELVDYI TISRGCLTEQ TYPEVVRMVS
     CNIFRTLPPS DSNEFDPEED EPTLEASWPH LQLVYEFFIR FLESQ