CLRN1_HUMAN
ID CLRN1_HUMAN Reviewed; 232 AA.
AC P58418; D3DNJ3; E1ACU9; Q8N6A9;
DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 2.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Clarin-1;
DE AltName: Full=Usher syndrome type-3 protein;
GN Name=CLRN1; Synonyms=USH3A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANTS USH3A LYS-120 AND
RP 153-ILE-LEU-154 DELINS MET.
RX PubMed=11524702; DOI=10.1086/323610;
RA Joensuu T., Haemaelaeinen R., Yuan B., Johnson C., Tegelberg S.,
RA Gasparini P., Zelante L., Pirvola U., Pakarinen L., Lehesjoki A.-E.,
RA de la Chapelle A., Sankila E.-M.;
RT "Mutations in a novel gene with transmembrane domains underlie Usher
RT syndrome type 3.";
RL Am. J. Hum. Genet. 69:673-684(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS USH3A LYS-48 AND
RP PRO-150.
RX PubMed=12145752; DOI=10.1086/342098;
RA Fields R.R., Zhou G., Huang D., Davis J.R., Moeller C., Jacobson S.G.,
RA Kimberling W.J., Sumegi J.;
RT "Usher syndrome type III: revised genomic structure of the USH3 gene and
RT identification of novel mutations.";
RL Am. J. Hum. Genet. 71:607-617(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT USH3A LYS-48, AND FUNCTION.
RC TISSUE=Retina;
RX PubMed=12080385; DOI=10.1038/sj.ejhg.5200831;
RA Adato A., Vreugde S., Joensuu T., Avidan N., Hamalainen R., Belenkiy O.,
RA Olender T., Bonne-Tamir B., Ben-Asher E., Espinos C., Millan J.M.,
RA Lehesjoki A.-E., Flannery J.G., Avraham K.B., Pietrokovski S.,
RA Sankila E.-M., Beckmann J.S., Lancet D.;
RT "USH3A transcripts encode clarin-1, a four-transmembrane-domain protein
RT with a possible role in sensory synapses.";
RL Eur. J. Hum. Genet. 10:339-350(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND ALTERNATIVE SPLICING.
RC TISSUE=Retina;
RX PubMed=20717163; DOI=10.1038/ejhg.2010.140;
RA Vastinsalo H., Jalkanen R., Dinculescu A., Isosomppi J., Geller S.,
RA Flannery J.G., Hauswirth W.W., Sankila E.M.;
RT "Alternative splice variants of the USH3A gene Clarin 1 (CLRN1).";
RL Eur. J. Hum. Genet. 19:30-35(2011).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP VARIANT USH3A GLY-40.
RX PubMed=15521980; DOI=10.1111/j.1399-0004.2004.00352.x;
RA Aller E., Jaijo T., Oltra S., Alio J., Galan F., Najera C., Beneyto M.,
RA Millan J.M.;
RT "Mutation screening of USH3 gene (clarin-1) in Spanish patients with Usher
RT syndrome: low prevalence and phenotypic variability.";
RL Clin. Genet. 66:525-529(2004).
RN [9]
RP VARIANT USH3A PRO-105.
RX PubMed=18273898; DOI=10.1002/humu.9524;
RA Dreyer B., Brox V., Tranebjaerg L., Rosenberg T., Sadeghi A.M., Moeller C.,
RA Nilssen O.;
RT "Spectrum of USH2A mutations in Scandinavian patients with Usher syndrome
RT type II.";
RL Hum. Mutat. 29:451-451(2008).
RN [10]
RP VARIANTS RP61 LEU-31 AND TRP-154, CHARACTERIZATION OF VARIANTS RP61 LEU-31
RP AND TRP-154, AND SUBCELLULAR LOCATION.
RX PubMed=21310491; DOI=10.1016/j.ophtha.2010.10.047;
RA Khan M.I., Kersten F.F., Azam M., Collin R.W., Hussain A., Shah S.T.,
RA Keunen J.E., Kremer H., Cremers F.P., Qamar R., den Hollander A.I.;
RT "CLRN1 mutations cause nonsyndromic retinitis pigmentosa.";
RL Ophthalmology 118:1444-1448(2011).
RN [11]
RP VARIANT USH3A ASN-168.
RX PubMed=23304067;
RA Garcia-Garcia G., Aparisi M.J., Rodrigo R., Sequedo M.D., Espinos C.,
RA Rosell J., Olea J.L., Mendivil M.P., Ramos-Arroyo M.A., Ayuso C., Jaijo T.,
RA Aller E., Millan J.M.;
RT "Two novel disease-causing mutations in the CLRN1 gene in patients with
RT Usher syndrome type 3.";
RL Mol. Vis. 18:3070-3078(2012).
CC -!- FUNCTION: May have a role in the excitatory ribbon synapse junctions
CC between hair cells and cochlear ganglion cells and presumably also in
CC analogous synapses within the retina. {ECO:0000269|PubMed:12080385}.
CC -!- INTERACTION:
CC P58418; Q9BVK2: ALG8; NbExp=3; IntAct=EBI-17274839, EBI-3921603;
CC P58418; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-17274839, EBI-12244618;
CC P58418; O14523: C2CD2L; NbExp=3; IntAct=EBI-17274839, EBI-12822627;
CC P58418; Q8WVQ1: CANT1; NbExp=3; IntAct=EBI-17274839, EBI-16770554;
CC P58418; Q8NHW4: CCL4L2; NbExp=3; IntAct=EBI-17274839, EBI-10271156;
CC P58418; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-17274839, EBI-12256978;
CC P58418; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-17274839, EBI-12019274;
CC P58418; Q8N682: DRAM1; NbExp=3; IntAct=EBI-17274839, EBI-10305400;
CC P58418; Q8N5W8: FAM24B; NbExp=3; IntAct=EBI-17274839, EBI-13383724;
CC P58418; Q9Y231: FUT9; NbExp=3; IntAct=EBI-17274839, EBI-3922408;
CC P58418; P11215: ITGAM; NbExp=3; IntAct=EBI-17274839, EBI-2568251;
CC P58418; Q6N075: MFSD5; NbExp=3; IntAct=EBI-17274839, EBI-3920969;
CC P58418; O14880: MGST3; NbExp=3; IntAct=EBI-17274839, EBI-724754;
CC P58418; Q8IXM6: NRM; NbExp=3; IntAct=EBI-17274839, EBI-10262547;
CC P58418; O75396: SEC22B; NbExp=3; IntAct=EBI-17274839, EBI-1058865;
CC P58418; Q8N130: SLC34A3; NbExp=3; IntAct=EBI-17274839, EBI-17769653;
CC P58418; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-17274839, EBI-2844246;
CC P58418; Q9BVK8: TMEM147; NbExp=3; IntAct=EBI-17274839, EBI-348587;
CC P58418; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-17274839, EBI-347385;
CC P58418; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-17274839, EBI-11528917;
CC P58418; P56557: TMEM50B; NbExp=3; IntAct=EBI-17274839, EBI-12366453;
CC P58418; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-17274839, EBI-2548832;
CC P58418; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-17274839, EBI-11724433;
CC P58418; Q9NRS4: TMPRSS4; NbExp=3; IntAct=EBI-17274839, EBI-10313040;
CC P58418; Q53HI1: UNC50; NbExp=3; IntAct=EBI-17274839, EBI-7601760;
CC P58418; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-17274839, EBI-12837904;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21310491};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Comment=Additional isoforms seem to exist.;
CC Name=1;
CC IsoId=P58418-3; Sequence=Displayed;
CC Name=2; Synonyms=A;
CC IsoId=P58418-1; Sequence=VSP_022868, VSP_022869;
CC Name=3; Synonyms=0-2-2b-3;
CC IsoId=P58418-4; Sequence=VSP_043303;
CC -!- TISSUE SPECIFICITY: Widely expressed. Found in the retina.
CC -!- DISEASE: Usher syndrome 3A (USH3A) [MIM:276902]: USH is a genetically
CC heterogeneous condition characterized by the association of retinitis
CC pigmentosa with sensorineural deafness. Age at onset and differences in
CC auditory and vestibular function distinguish Usher syndrome type 1
CC (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3).
CC USH3 is characterized by postlingual, progressive hearing loss,
CC variable vestibular dysfunction, and onset of retinitis pigmentosa
CC symptoms, including nyctalopia, constriction of the visual fields, and
CC loss of central visual acuity, usually by the second decade of life.
CC {ECO:0000269|PubMed:11524702, ECO:0000269|PubMed:12080385,
CC ECO:0000269|PubMed:12145752, ECO:0000269|PubMed:15521980,
CC ECO:0000269|PubMed:18273898, ECO:0000269|PubMed:23304067}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- DISEASE: Retinitis pigmentosa 61 (RP61) [MIM:614180]: A retinal
CC dystrophy belonging to the group of pigmentary retinopathies. Retinitis
CC pigmentosa is characterized by retinal pigment deposits visible on
CC fundus examination and primary loss of rod photoreceptor cells followed
CC by secondary loss of cone photoreceptors. Patients typically have night
CC vision blindness and loss of midperipheral visual field. As their
CC condition progresses, they lose their far peripheral visual field and
CC eventually central vision as well. {ECO:0000269|PubMed:21310491}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the clarin family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Mutations of the USH3A gene; Note=Retina
CC International's Scientific Newsletter;
CC URL="https://www.retina-international.org/files/sci-news/ush3mut.htm";
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DR EMBL; AF388366; AAL09581.1; -; mRNA.
DR EMBL; AF482697; AAN07148.1; -; mRNA.
DR EMBL; AF495717; AAM88774.1; -; mRNA.
DR EMBL; HM626132; ADM63096.1; -; mRNA.
DR EMBL; AC020636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW78814.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78815.1; -; Genomic_DNA.
DR EMBL; BC074970; AAH74970.1; -; mRNA.
DR EMBL; BC074971; AAH74971.1; -; mRNA.
DR CCDS; CCDS3153.1; -. [P58418-3]
DR CCDS; CCDS35492.1; -. [P58418-1]
DR CCDS; CCDS56285.1; -. [P58418-4]
DR RefSeq; NP_001182723.1; NM_001195794.1. [P58418-4]
DR RefSeq; NP_443721.1; NM_052995.2. [P58418-1]
DR RefSeq; NP_777367.1; NM_174878.2. [P58418-3]
DR AlphaFoldDB; P58418; -.
DR BioGRID; 113244; 30.
DR IntAct; P58418; 26.
DR STRING; 9606.ENSP00000329158; -.
DR TCDB; 9.A.46.1.1; the clarin (clrn) family.
DR GlyGen; P58418; 1 site.
DR iPTMnet; P58418; -.
DR PhosphoSitePlus; P58418; -.
DR BioMuta; CLRN1; -.
DR DMDM; 125987806; -.
DR PRIDE; P58418; -.
DR ProteomicsDB; 57075; -. [P58418-1]
DR Antibodypedia; 52945; 34 antibodies from 12 providers.
DR DNASU; 7401; -.
DR Ensembl; ENST00000295911.6; ENSP00000295911.2; ENSG00000163646.12. [P58418-1]
DR Ensembl; ENST00000327047.6; ENSP00000322280.1; ENSG00000163646.12. [P58418-3]
DR Ensembl; ENST00000328863.8; ENSP00000329158.4; ENSG00000163646.12. [P58418-4]
DR GeneID; 7401; -.
DR KEGG; hsa:7401; -.
DR MANE-Select; ENST00000327047.6; ENSP00000322280.1; NM_174878.3; NP_777367.1.
DR UCSC; uc003eyj.3; human. [P58418-3]
DR CTD; 7401; -.
DR DisGeNET; 7401; -.
DR GeneCards; CLRN1; -.
DR GeneReviews; CLRN1; -.
DR HGNC; HGNC:12605; CLRN1.
DR HPA; ENSG00000163646; Group enriched (adrenal gland, retina).
DR MalaCards; CLRN1; -.
DR MIM; 276902; phenotype.
DR MIM; 606397; gene.
DR MIM; 614180; phenotype.
DR neXtProt; NX_P58418; -.
DR OpenTargets; ENSG00000163646; -.
DR Orphanet; 791; Retinitis pigmentosa.
DR Orphanet; 231183; Usher syndrome type 3.
DR PharmGKB; PA37231; -.
DR VEuPathDB; HostDB:ENSG00000163646; -.
DR eggNOG; ENOG502QQVB; Eukaryota.
DR GeneTree; ENSGT00850000132319; -.
DR HOGENOM; CLU_095723_0_0_1; -.
DR InParanoid; P58418; -.
DR OMA; AIGTQLW; -.
DR OrthoDB; 1188976at2759; -.
DR PhylomeDB; P58418; -.
DR TreeFam; TF331875; -.
DR PathwayCommons; P58418; -.
DR SignaLink; P58418; -.
DR BioGRID-ORCS; 7401; 8 hits in 1063 CRISPR screens.
DR ChiTaRS; CLRN1; human.
DR GeneWiki; CLRN1; -.
DR GenomeRNAi; 7401; -.
DR Pharos; P58418; Tbio.
DR PRO; PR:P58418; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; P58418; protein.
DR Bgee; ENSG00000163646; Expressed in adrenal tissue and 44 other tissues.
DR ExpressionAtlas; P58418; baseline and differential.
DR Genevisible; P58418; HS.
DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030027; C:lamellipodium; IDA:MGI.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0032420; C:stereocilium; IEA:Ensembl.
DR GO; GO:0030140; C:trans-Golgi network transport vesicle; IEA:Ensembl.
DR GO; GO:0007015; P:actin filament organization; IDA:MGI.
DR GO; GO:0060088; P:auditory receptor cell stereocilium organization; IEA:Ensembl.
DR GO; GO:0048870; P:cell motility; IDA:MGI.
DR GO; GO:0050957; P:equilibrioception; IMP:HGNC-UCL.
DR GO; GO:0045494; P:photoreceptor cell maintenance; IMP:HGNC-UCL.
DR GO; GO:0010592; P:positive regulation of lamellipodium assembly; IDA:MGI.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0050953; P:sensory perception of light stimulus; IMP:HGNC-UCL.
DR GO; GO:0007605; P:sensory perception of sound; IMP:HGNC-UCL.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR026748; Clarin.
DR PANTHER; PTHR31548; PTHR31548; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Deafness; Disease variant;
KW Glycoprotein; Hearing; Membrane; Reference proteome; Retinitis pigmentosa;
KW Sensory transduction; Transmembrane; Transmembrane helix; Usher syndrome;
KW Vision.
FT CHAIN 1..232
FT /note="Clarin-1"
FT /id="PRO_0000065729"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..85
FT /note="MPSQQKKIIFCMAGVFSFACALGVVTALGTPLWIKATVLCKTGALLVNASGQ
FT ELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSF -> MQALQQQPV (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:11524702"
FT /id="VSP_022868"
FT VAR_SEQ 144
FT /note="S -> SVALWLPATRHQAQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:20717163"
FT /id="VSP_043303"
FT VAR_SEQ 191..232
FT /note="VIFFCFFVHFLNGLLIRLAGFQFPFAKSKDAETTNVAADLMY -> LTKGHS
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11524702"
FT /id="VSP_022869"
FT VARIANT 7
FT /note="K -> I (in dbSNP:rs3796241)"
FT /id="VAR_053825"
FT VARIANT 31
FT /note="P -> L (in RP61; the mutant protein is retained in
FT the endoplasmic reticulum; dbSNP:rs374390376)"
FT /evidence="ECO:0000269|PubMed:21310491"
FT /id="VAR_066673"
FT VARIANT 40
FT /note="C -> G (in USH3A; dbSNP:rs121908143)"
FT /evidence="ECO:0000269|PubMed:15521980"
FT /id="VAR_054555"
FT VARIANT 48
FT /note="N -> K (in USH3A; dbSNP:rs111033258)"
FT /evidence="ECO:0000269|PubMed:12080385,
FT ECO:0000269|PubMed:12145752"
FT /id="VAR_030345"
FT VARIANT 105
FT /note="S -> P (in USH3A)"
FT /evidence="ECO:0000269|PubMed:18273898"
FT /id="VAR_054556"
FT VARIANT 120
FT /note="M -> K (in USH3A; dbSNP:rs121908141)"
FT /evidence="ECO:0000269|PubMed:11524702"
FT /id="VAR_012241"
FT VARIANT 150
FT /note="L -> P (in USH3A; dbSNP:rs121908142)"
FT /evidence="ECO:0000269|PubMed:12145752"
FT /id="VAR_030346"
FT VARIANT 153..154
FT /note="IL -> M (in USH3A)"
FT /evidence="ECO:0000269|PubMed:11524702"
FT /id="VAR_012242"
FT VARIANT 154
FT /note="L -> W (in RP61; the mutant protein is retained in
FT the endoplasmic reticulum; dbSNP:rs775098953)"
FT /evidence="ECO:0000269|PubMed:21310491"
FT /id="VAR_066674"
FT VARIANT 168
FT /note="I -> N (in USH3A)"
FT /evidence="ECO:0000269|PubMed:23304067"
FT /id="VAR_071434"
SQ SEQUENCE 232 AA; 25719 MW; 2713C621FEBE4281 CRC64;
MPSQQKKIIF CMAGVFSFAC ALGVVTALGT PLWIKATVLC KTGALLVNAS GQELDKFMGE
MQYGLFHGEG VRQCGLGARP FRFSFFPDLL KAIPVSIHVN VILFSAILIV LTMVGTAFFM
YNAFGKPFET LHGPLGLYLL SFISGSCGCL VMILFASEVK IHHLSEKIAN YKEGTYVYKT
QSEKYTTSFW VIFFCFFVHF LNGLLIRLAG FQFPFAKSKD AETTNVAADL MY
