ID   CLRN1_RAT               Reviewed;         232 AA.
AC   Q8CJ58;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Clarin-1;
DE   AltName: Full=Usher syndrome type-3 protein homolog;
GN   Name=Clrn1; Synonyms=Ush3a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=12145752; DOI=10.1086/342098;
RA   Fields R.R., Zhou G., Huang D., Davis J.R., Moeller C., Jacobson S.G.,
RA   Kimberling W.J., Sumegi J.;
RT   "Usher syndrome type III: revised genomic structure of the USH3 gene and
RT   identification of novel mutations.";
RL   Am. J. Hum. Genet. 71:607-617(2002).
CC   -!- FUNCTION: May have a role in the excitatory ribbon synapse junctions
CC       between hair cells and cochlear ganglion cells and presumably also in
CC       analogous synapses within the retina. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P58418};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the clarin family. {ECO:0000305}.
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DR   EMBL; AF482698; AAN07149.1; -; mRNA.
DR   AlphaFoldDB; Q8CJ58; -.
DR   STRING; 10116.ENSRNOP00000060407; -.
DR   CarbonylDB; Q8CJ58; -.
DR   GlyGen; Q8CJ58; 2 sites.
DR   PaxDb; Q8CJ58; -.
DR   UCSC; RGD:628779; rat.
DR   RGD; 628779; Clrn1.
DR   eggNOG; ENOG502QQVB; Eukaryota.
DR   InParanoid; Q8CJ58; -.
DR   PRO; PR:Q8CJ58; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0045178; C:basal part of cell; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030027; C:lamellipodium; ISO:RGD.
DR   GO; GO:0015630; C:microtubule cytoskeleton; ISO:RGD.
DR   GO; GO:0005902; C:microvillus; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0032420; C:stereocilium; ISO:RGD.
DR   GO; GO:0030140; C:trans-Golgi network transport vesicle; ISO:RGD.
DR   GO; GO:0007015; P:actin filament organization; ISO:RGD.
DR   GO; GO:0060117; P:auditory receptor cell development; ISO:RGD.
DR   GO; GO:0060088; P:auditory receptor cell stereocilium organization; ISO:RGD.
DR   GO; GO:0048870; P:cell motility; ISO:RGD.
DR   GO; GO:0050957; P:equilibrioception; ISO:RGD.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; ISO:RGD.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; ISO:RGD.
DR   GO; GO:0010592; P:positive regulation of lamellipodium assembly; ISO:RGD.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0050953; P:sensory perception of light stimulus; ISO:RGD.
DR   GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   InterPro; IPR026748; Clarin.
DR   PANTHER; PTHR31548; PTHR31548; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Hearing; Membrane; Reference proteome;
KW   Sensory transduction; Transmembrane; Transmembrane helix; Vision.
FT   CHAIN           1..232
FT                   /note="Clarin-1"
FT                   /id="PRO_0000274696"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        48
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        184
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   232 AA;  25782 MW;  244040648E7419C5 CRC64;
     MPSQQKKIIF CMAGVFSFAC ALGVVTALGT PLWIKATVLC KTGALLVNAS GQELDKFMGE
     MQYGLFHGEG VRQCGLGARP FRFSFFPDLL KAIPVSIHVN IILFSMILVV LTMVGTAFFM
     YNAFGKPFES LHGPLGLYLV SFISGSCGCL VMILFASEVK IHRLSEKIAN FKEGTYAYKT
     QNENYTTSFW VVFICFFVHF LNGLLIRLAG FQFPFTKSKE TETTNVASDL MY