CLRN3_MOUSE
ID CLRN3_MOUSE Reviewed; 226 AA.
AC Q8BHH8;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Clarin-3;
DE AltName: Full=Transmembrane protein 12;
GN Name=Clrn3; Synonyms=Tmem12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Amnion, Cecum, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the clarin family. {ECO:0000305}.
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DR EMBL; AK033715; BAC28442.1; -; mRNA.
DR EMBL; AK085267; BAC39405.1; -; mRNA.
DR EMBL; AK146608; BAE27300.1; -; mRNA.
DR EMBL; BC036176; AAH36176.1; -; mRNA.
DR CCDS; CCDS21943.1; -.
DR RefSeq; NP_848784.1; NM_178669.5.
DR AlphaFoldDB; Q8BHH8; -.
DR STRING; 10090.ENSMUSP00000056245; -.
DR GlyGen; Q8BHH8; 1 site.
DR iPTMnet; Q8BHH8; -.
DR PhosphoSitePlus; Q8BHH8; -.
DR jPOST; Q8BHH8; -.
DR PaxDb; Q8BHH8; -.
DR PRIDE; Q8BHH8; -.
DR ProteomicsDB; 283862; -.
DR Antibodypedia; 19247; 116 antibodies from 21 providers.
DR DNASU; 212070; -.
DR Ensembl; ENSMUST00000053716; ENSMUSP00000056245; ENSMUSG00000050866.
DR GeneID; 212070; -.
DR KEGG; mmu:212070; -.
DR UCSC; uc009ked.1; mouse.
DR CTD; 119467; -.
DR MGI; MGI:2142022; Clrn3.
DR VEuPathDB; HostDB:ENSMUSG00000050866; -.
DR eggNOG; ENOG502S2S8; Eukaryota.
DR GeneTree; ENSGT00850000132319; -.
DR HOGENOM; CLU_1224445_0_0_1; -.
DR InParanoid; Q8BHH8; -.
DR OMA; PTGVYTW; -.
DR OrthoDB; 1309543at2759; -.
DR PhylomeDB; Q8BHH8; -.
DR TreeFam; TF331875; -.
DR BioGRID-ORCS; 212070; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Clrn3; mouse.
DR PRO; PR:Q8BHH8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BHH8; protein.
DR Bgee; ENSMUSG00000050866; Expressed in small intestine Peyer's patch and 61 other tissues.
DR Genevisible; Q8BHH8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007605; P:sensory perception of sound; IEA:UniProt.
DR InterPro; IPR026748; Clarin.
DR PANTHER; PTHR31548; PTHR31548; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..226
FT /note="Clarin-3"
FT /id="PRO_0000274699"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 226 AA; 25350 MW; 1CBE4726BA437DFA CRC64;
MPTTQKTLMF LSGFLTSLGS VVVICSILAT QAWITSRIFF TDAISNGTIV ITYGLFRGTS
AQELNEGLQD LDKNFEVLGI LDNSSQKSLH LVVILLLILS LAASVLSSVF TFYNSISNPY
QTFLGPMGVY TWNGLSASFV FLAMVLFVGN AESNHLSDKL SQKLYPDTTN KRTTHTYGYS
FWLTLHVIFL NIVTAVIIIF YQKARYRQKQ EQRKPVEYAP RDGILF
