ID   CLRN3_RAT               Reviewed;         226 AA.
AC   Q6AYR5;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Clarin-3;
DE   AltName: Full=Transmembrane protein 12;
GN   Name=Clrn3; Synonyms=Tmem12;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the clarin family. {ECO:0000305}.
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DR   EMBL; BC078942; AAH78942.1; -; mRNA.
DR   RefSeq; NP_001014048.1; NM_001014026.1.
DR   AlphaFoldDB; Q6AYR5; -.
DR   IntAct; Q6AYR5; 1.
DR   STRING; 10116.ENSRNOP00000035233; -.
DR   GlyGen; Q6AYR5; 2 sites.
DR   PaxDb; Q6AYR5; -.
DR   Ensembl; ENSRNOT00000031397; ENSRNOP00000035233; ENSRNOG00000028288.
DR   GeneID; 309082; -.
DR   KEGG; rno:309082; -.
DR   UCSC; RGD:1305043; rat.
DR   CTD; 119467; -.
DR   RGD; 1305043; Clrn3.
DR   eggNOG; ENOG502S2S8; Eukaryota.
DR   GeneTree; ENSGT00850000132319; -.
DR   InParanoid; Q6AYR5; -.
DR   OMA; PTGVYTW; -.
DR   OrthoDB; 1309543at2759; -.
DR   PhylomeDB; Q6AYR5; -.
DR   TreeFam; TF331875; -.
DR   PRO; PR:Q6AYR5; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000028288; Expressed in jejunum and 9 other tissues.
DR   Genevisible; Q6AYR5; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:UniProt.
DR   InterPro; IPR026748; Clarin.
DR   PANTHER; PTHR31548; PTHR31548; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..226
FT                   /note="Clarin-3"
FT                   /id="PRO_0000274700"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        46
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   226 AA;  25278 MW;  EB13B061B4E6C385 CRC64;
     MPTTQKTLMF LSGFLTSLGS VVVICSILGT QAWITSKIFF TDTISNGTIA ITYGLFRGTS
     SQDLNEGLQE LDKNFEVLGI LSNSSQKSLH VVVIILLILS LAASLLSSMF TFYNSISNPY
     QTFLGPMGVY TWNGLSASFV FLTMVLFVGN VDSNHLSEKL SQTLYPDAIN KKTTHTYGYS
     FWLILLVILL NIVTVVIIIF YQKARYHQKQ EQRKPVEYAP RDGILF