CLSS_HAEMA
ID CLSS_HAEMA Reviewed; 83 AA.
AC Q25088;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Calsensin;
DE AltName: Full=LAN3-6 antigen;
OS Haemopis marmorata (Green horse leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Hirudinida; Hirudiniformes; Haemopidae; Haemopis.
OX NCBI_TaxID=38567;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7775579; DOI=10.1083/jcb.129.5.1355;
RA Briggs K.K., Silvers A.J., Johansen K.M., Johansen J.;
RT "Calsensin: a novel calcium-binding protein expressed in a subset of
RT peripheral leech neurons fasciculating in a single axon tract.";
RL J. Cell Biol. 129:1355-1362(1995).
CC -!- FUNCTION: May function as a trigger protein which interacts with a
CC larger protein. May mediate calcium-dependent signal transduction
CC events in the growth cones and axons of a small group of sensory
CC neurons which fasciculate in a single axon tract.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Selectively expressed in a small group of neurons.
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DR EMBL; U22066; AAC46630.1; -; mRNA.
DR PIR; A57231; A57231.
DR PDB; 1YX7; NMR; -; A=1-83.
DR PDB; 1YX8; NMR; -; A=1-83.
DR PDBsum; 1YX7; -.
DR PDBsum; 1YX8; -.
DR AlphaFoldDB; Q25088; -.
DR BMRB; Q25088; -.
DR SMR; Q25088; -.
DR EvolutionaryTrace; Q25088; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Calcium; Cytoplasm; Metal-binding; Repeat.
FT CHAIN 1..83
FT /note="Calsensin"
FT /id="PRO_0000073855"
FT DOMAIN 4..39
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 46..81
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 17
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 19
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 21
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 23
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 28
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 59
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 61
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 65
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 70
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT HELIX 8..16
FT /evidence="ECO:0007829|PDB:1YX7"
FT STRAND 17..19
FT /evidence="ECO:0007829|PDB:1YX7"
FT STRAND 21..23
FT /evidence="ECO:0007829|PDB:1YX7"
FT HELIX 26..36
FT /evidence="ECO:0007829|PDB:1YX7"
FT TURN 40..47
FT /evidence="ECO:0007829|PDB:1YX7"
FT HELIX 48..55
FT /evidence="ECO:0007829|PDB:1YX7"
FT TURN 56..58
FT /evidence="ECO:0007829|PDB:1YX7"
FT STRAND 60..62
FT /evidence="ECO:0007829|PDB:1YX7"
FT HELIX 68..79
FT /evidence="ECO:0007829|PDB:1YX7"
SQ SEQUENCE 83 AA; 9102 MW; 2B11CCF3A55FDFC2 CRC64;
MACKVKAELE AAFKKLDANG DGYVTALELQ TFMVTLDAYK ALSKDKVKEA SAKLIKMADK
NSDGKISKEE FLNANAELLC QLK
