CLTR1_CAVPO
ID CLTR1_CAVPO Reviewed; 340 AA.
AC Q2NNR5;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Cysteinyl leukotriene receptor 1;
DE Short=CysLTR1;
DE AltName: Full=Cysteinyl leukotriene D4 receptor;
DE Short=LTD4 receptor;
GN Name=CYSLTR1;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Ito Y., Nishimura Y., Tanaka T.;
RT "Molecular cloning and functional characterization of guinea pig cysteinyl
RT leukotriene receptor 1 and 2.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for cysteinyl leukotrienes mediating
CC bronchoconstriction of individuals with and without asthma. Stimulation
CC by LTD4 results in the contraction and proliferation of smooth muscle,
CC edema, eosinophil migration and damage to the mucus layer in the lung.
CC This response is mediated via a G-protein that activates a
CC phosphatidylinositol-calcium second messenger system (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY236968; AAP75558.1; -; mRNA.
DR RefSeq; NP_001166412.1; NM_001172941.2.
DR AlphaFoldDB; Q2NNR5; -.
DR SMR; Q2NNR5; -.
DR STRING; 10141.ENSCPOP00000001902; -.
DR BindingDB; Q2NNR5; -.
DR ChEMBL; CHEMBL5645; -.
DR DrugCentral; Q2NNR5; -.
DR Ensembl; ENSCPOT00000002128; ENSCPOP00000001902; ENSCPOG00000002100.
DR GeneID; 100135514; -.
DR KEGG; cpoc:100135514; -.
DR CTD; 10800; -.
DR eggNOG; ENOG502QUJU; Eukaryota.
DR GeneTree; ENSGT01050000244810; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q2NNR5; -.
DR OMA; CVMTLPL; -.
DR OrthoDB; 791328at2759; -.
DR TreeFam; TF350009; -.
DR PRO; PR:Q2NNR5; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000002100; Expressed in uterine cervix and 10 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR GO; GO:0004974; F:leukotriene receptor activity; IEA:Ensembl.
DR GO; GO:0006816; P:calcium ion transport; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006935; P:chemotaxis; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; IEA:Ensembl.
DR InterPro; IPR013310; CLT1_recept.
DR InterPro; IPR004071; Cyst_leuk_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01902; CYSLT1RECPTR.
DR PRINTS; PR01533; CYSLTRECPTR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..340
FT /note="Cysteinyl leukotriene receptor 1"
FT /id="PRO_0000281573"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..279
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 301..340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 99..176
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 340 AA; 38984 MW; DE544F975FB65F76 CRC64;
MDETGNPTIP PASNNTCYDS IDDFRNQVYS TLYSMISVVG FFGNGFVLYV LVKTYHEKSA
FQVYMINLAV ADLLCVCTLP LRVAYYVHKG IWLFGDFLCR LSTYALYVNL YCSIFFMTAM
SFFRCVAIVF PVQNISLVTQ KKARLVCIAI WMFVILTSSP FLMANTYKDE KNNTKCFEPP
QDNQAKNYVL ILHYVSLFIG FIIPFITIIV CYTMIIFTLL KSSMKKNLSS RKRAIGMIIV
VTAAFLVSFM PYHIQRTIHL HFLHNKTKPC DSILRMQKSV VITLSLAASN CCFDPLLYFF
SGGNFRRRLS TIRKYSLSSM TYIPKKKTSL PQKGKDICKE
