CLTR1_RAT
ID CLTR1_RAT Reviewed; 339 AA.
AC Q924T8;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Cysteinyl leukotriene receptor 1;
DE Short=CysLTR1;
GN Name=Cysltr1; Synonyms=Cyslt1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Takasaki J., Kamohara M., Saito T., Matsumoto M., Matsumoto S., Ohishi T.,
RA Soga T., Matsushime H., Furuichi K.;
RT "Characterization of cloned rat and porcine cysteinyl leukotriene
RT receptors.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for cysteinyl leukotrienes mediating constriction of
CC the microvascular smooth muscle during an inflammatory response. This
CC response is mediated via a G-protein that activates a
CC phosphatidylinositol-calcium second messenger system (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB052685; BAB60825.1; -; mRNA.
DR RefSeq; NP_446093.1; NM_053641.1.
DR RefSeq; XP_006257220.1; XM_006257158.2.
DR AlphaFoldDB; Q924T8; -.
DR SMR; Q924T8; -.
DR STRING; 10116.ENSRNOP00000040761; -.
DR BindingDB; Q924T8; -.
DR ChEMBL; CHEMBL1075218; -.
DR GlyGen; Q924T8; 2 sites.
DR iPTMnet; Q924T8; -.
DR PhosphoSitePlus; Q924T8; -.
DR PaxDb; Q924T8; -.
DR Ensembl; ENSRNOT00000042799; ENSRNOP00000040761; ENSRNOG00000037845.
DR Ensembl; ENSRNOT00000092418; ENSRNOP00000075854; ENSRNOG00000037845.
DR GeneID; 114099; -.
DR KEGG; rno:114099; -.
DR UCSC; RGD:619796; rat.
DR CTD; 10800; -.
DR RGD; 619796; Cysltr1.
DR eggNOG; ENOG502QUJU; Eukaryota.
DR GeneTree; ENSGT01050000244810; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q924T8; -.
DR OrthoDB; 791328at2759; -.
DR PhylomeDB; Q924T8; -.
DR Reactome; R-RNO-391906; Leukotriene receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:Q924T8; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000037845; Expressed in stomach and 15 other tissues.
DR ExpressionAtlas; Q924T8; baseline and differential.
DR Genevisible; Q924T8; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
DR GO; GO:0001631; F:cysteinyl leukotriene receptor activity; IBA:GO_Central.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004974; F:leukotriene receptor activity; IDA:RGD.
DR GO; GO:0006816; P:calcium ion transport; ISO:RGD.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:RGD.
DR GO; GO:0006935; P:chemotaxis; ISO:RGD.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IDA:RGD.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; ISO:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:RGD.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.
DR InterPro; IPR013310; CLT1_recept.
DR InterPro; IPR004071; Cyst_leuk_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01902; CYSLT1RECPTR.
DR PRINTS; PR01533; CYSLTRECPTR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..339
FT /note="Cysteinyl leukotriene receptor 1"
FT /id="PRO_0000069302"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 165..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..339
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..175
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 339 AA; 39143 MW; 281B41DF050DF8EA CRC64;
MVGAENMTAS FSNNRCHDTI DEFRNQVYST MYSMISVVGF FGNSFVLYVL IKTYHEKSAF
QVYMINLAIA DLLCVCTLPL RVVYYVHKGK WFFGDFLCRL TTYALYVNLY CSIFFMTAMS
FFRCVAIVFP VQNINLVTQK KARFVCVGIW IFVILTSSPF LLSKSYQDEK NNTKCFEPPQ
DKQTKKYVLV LHYVSLIFGF IIPFVTIIVC YTMIILTLLK NTMKKNLPSR RKAIGMIIVV
TAAFLVSFMP YHIQRAIHLH FLHSETRSCD SVLRMQKSVV ITLSLAASNC CFDPLLYFFS
GGNFRRRLST FRKHSLSSMT YIPKKKASLP EKGEEMCKE
