CLTR2_HUMAN
ID CLTR2_HUMAN Reviewed; 346 AA.
AC Q9NS75; Q9HCQ2;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Cysteinyl leukotriene receptor 2;
DE Short=CysLTR2;
DE AltName: Full=G-protein coupled receptor GPCR21;
DE Short=hGPCR21;
DE AltName: Full=G-protein coupled receptor HG57;
DE AltName: Full=HPN321;
GN Name=CYSLTR2; Synonyms=CYSLT2, CYSLT2R; ORFNames=PSEC0146;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=10913337; DOI=10.1006/bbrc.2000.3140;
RA Takasaki J., Kamohara M., Matsumoto M., Saito T., Sugimoto T., Ota T.,
RA Nishikawa T., Kawai Y., Masuho Y., Isogai T., Suzuki Y., Sugano S.,
RA Furuichi K.;
RT "The molecular characterization and tissue distribution of the human
RT cysteinyl leukotriene CysLT2 receptor.";
RL Biochem. Biophys. Res. Commun. 274:316-322(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10851239; DOI=10.1074/jbc.m003490200;
RA Heise C.E., O'Dowd B.F., Figueroa D.J., Sawyer N., Nguyen T., Im D.-S.,
RA Stocco R., Bellefeuille J.N., Abramovitz M., Cheng R., Williams D.L. Jr.,
RA Zeng Z., Liu Q., Ma L., Clements M.K., Coulombe N., Liu Y., Austin C.P.,
RA George S.R., O'Neill G.P., Metters K.M., Lynch K.R., Evans J.F.;
RT "Characterization of the human cysteinyl leukotriene 2 receptor.";
RL J. Biol. Chem. 275:30531-30536(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11093801; DOI=10.1124/mol.58.6.1601;
RA Nothacker H.-P., Wang Z., Zhu Y., Reinscheid R.K., Lin S.H.S., Civelli O.;
RT "Molecular cloning and characterization of a second human cysteinyl
RT leukotriene receptor: discovery of a subtype selective agonist.";
RL Mol. Pharmacol. 58:1601-1608(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-346.
RA Suga H.;
RT "Homo sapiens cysteinyl leukotriene receptor 1 like receptor.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for cysteinyl leukotrienes. The response is mediated
CC via a G-protein that activates a phosphatidylinositol-calcium second
CC messenger system. Stimulation by BAY u9773, a partial agonist, induces
CC specific contractions of pulmonary veins and might also have an
CC indirect role in the relaxation of the pulmonary vascular endothelium.
CC The rank order of affinities for the leukotrienes is LTC4 = LTD4 >>
CC LTE4.
CC -!- INTERACTION:
CC Q9NS75; Q12959: DLG1; NbExp=7; IntAct=EBI-3843579, EBI-357481;
CC Q9NS75; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-3843579, EBI-11959885;
CC Q9NS75; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-3843579, EBI-739832;
CC Q9NS75; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-3843579, EBI-11522433;
CC Q9NS75; Q14160: SCRIB; NbExp=3; IntAct=EBI-3843579, EBI-357345;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in the heart,
CC placenta, spleen, peripheral blood leukocytes and adrenal gland. In
CC lung, expressed in the interstitial macrophages, and slightly in smooth
CC muscle cells.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB038269; BAB03601.1; -; mRNA.
DR EMBL; AF254664; AAG17281.1; -; Genomic_DNA.
DR EMBL; AF279611; AAK69485.1; -; Genomic_DNA.
DR EMBL; AB083603; BAB89316.1; -; Genomic_DNA.
DR EMBL; AY389504; AAQ91330.1; -; Genomic_DNA.
DR EMBL; AL137118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069160; AAH69160.1; -; mRNA.
DR EMBL; AB041644; BAB16379.1; -; Genomic_DNA.
DR CCDS; CCDS9412.1; -.
DR RefSeq; NP_001295394.1; NM_001308465.2.
DR RefSeq; NP_001295396.1; NM_001308467.2.
DR RefSeq; NP_001295397.1; NM_001308468.2.
DR RefSeq; NP_001295398.1; NM_001308469.2.
DR RefSeq; NP_001295399.1; NM_001308470.2.
DR RefSeq; NP_001295400.1; NM_001308471.2.
DR RefSeq; NP_001295405.1; NM_001308476.2.
DR RefSeq; NP_065110.1; NM_020377.4.
DR AlphaFoldDB; Q9NS75; -.
DR SMR; Q9NS75; -.
DR BioGRID; 121371; 21.
DR IntAct; Q9NS75; 34.
DR MINT; Q9NS75; -.
DR STRING; 9606.ENSP00000282018; -.
DR BindingDB; Q9NS75; -.
DR ChEMBL; CHEMBL4330; -.
DR DrugBank; DB08855; Leukotriene C4.
DR DrugBank; DB11858; Leukotriene D4.
DR DrugBank; DB00716; Nedocromil.
DR DrugCentral; Q9NS75; -.
DR GuidetoPHARMACOLOGY; 270; -.
DR SwissLipids; SLP:000001584; -.
DR GlyGen; Q9NS75; 4 sites.
DR iPTMnet; Q9NS75; -.
DR PhosphoSitePlus; Q9NS75; -.
DR BioMuta; CYSLTR2; -.
DR DMDM; 20138034; -.
DR MassIVE; Q9NS75; -.
DR PaxDb; Q9NS75; -.
DR PeptideAtlas; Q9NS75; -.
DR PRIDE; Q9NS75; -.
DR ProteomicsDB; 82506; -.
DR Antibodypedia; 9403; 249 antibodies from 27 providers.
DR DNASU; 57105; -.
DR Ensembl; ENST00000282018.4; ENSP00000282018.3; ENSG00000152207.8.
DR Ensembl; ENST00000614739.4; ENSP00000477930.1; ENSG00000152207.8.
DR Ensembl; ENST00000682523.1; ENSP00000508181.1; ENSG00000152207.8.
DR GeneID; 57105; -.
DR KEGG; hsa:57105; -.
DR MANE-Select; ENST00000682523.1; ENSP00000508181.1; NM_001308476.3; NP_001295405.1.
DR UCSC; uc010ada.2; human.
DR CTD; 57105; -.
DR DisGeNET; 57105; -.
DR GeneCards; CYSLTR2; -.
DR HGNC; HGNC:18274; CYSLTR2.
DR HPA; ENSG00000152207; Tissue enhanced (placenta, seminal vesicle).
DR MalaCards; CYSLTR2; -.
DR MIM; 605666; gene.
DR neXtProt; NX_Q9NS75; -.
DR OpenTargets; ENSG00000152207; -.
DR Orphanet; 39044; Uveal melanoma.
DR PharmGKB; PA38518; -.
DR VEuPathDB; HostDB:ENSG00000152207; -.
DR eggNOG; ENOG502RX8K; Eukaryota.
DR GeneTree; ENSGT01050000244810; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q9NS75; -.
DR OMA; CMLSICY; -.
DR OrthoDB; 930634at2759; -.
DR PhylomeDB; Q9NS75; -.
DR TreeFam; TF350009; -.
DR PathwayCommons; Q9NS75; -.
DR Reactome; R-HSA-163359; Glucagon signaling in metabolic regulation.
DR Reactome; R-HSA-391906; Leukotriene receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-420092; Glucagon-type ligand receptors.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR Reactome; R-HSA-9664535; LTC4-CYSLTR mediated IL4 production.
DR SignaLink; Q9NS75; -.
DR SIGNOR; Q9NS75; -.
DR BioGRID-ORCS; 57105; 12 hits in 1069 CRISPR screens.
DR GeneWiki; Cysteinyl_leukotriene_receptor_2; -.
DR GenomeRNAi; 57105; -.
DR Pharos; Q9NS75; Tchem.
DR PRO; PR:Q9NS75; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q9NS75; protein.
DR Bgee; ENSG00000152207; Expressed in right adrenal gland cortex and 113 other tissues.
DR ExpressionAtlas; Q9NS75; baseline and differential.
DR Genevisible; Q9NS75; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0001631; F:cysteinyl leukotriene receptor activity; IBA:GO_Central.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:Reactome.
DR GO; GO:0004974; F:leukotriene receptor activity; NAS:UniProtKB.
DR GO; GO:0071377; P:cellular response to glucagon stimulus; TAS:Reactome.
DR GO; GO:0006955; P:immune response; NAS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR InterPro; IPR013311; CLT2_recept.
DR InterPro; IPR004071; Cyst_leuk_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01903; CYSLT2RECPTR.
DR PRINTS; PR01533; CYSLTRECPTR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..346
FT /note="Cysteinyl leukotriene receptor 2"
FT /id="PRO_0000069303"
FT TOPO_DOM 1..42
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..72
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 94..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..245
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..286
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308..346
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 111..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 346 AA; 39635 MW; EB54A4A2DDCE5EE4 CRC64;
MERKFMSLQP SISVSEMEPN GTFSNNNSRN CTIENFKREF FPIVYLIIFF WGVLGNGLSI
YVFLQPYKKS TSVNVFMLNL AISDLLFIST LPFRADYYLR GSNWIFGDLA CRIMSYSLYV
NMYSSIYFLT VLSVVRFLAM VHPFRLLHVT SIRSAWILCG IIWILIMASS IMLLDSGSEQ
NGSVTSCLEL NLYKIAKLQT MNYIALVVGC LLPFFTLSIC YLLIIRVLLK VEVPESGLRV
SHRKALTTII ITLIIFFLCF LPYHTLRTVH LTTWKVGLCK DRLHKALVIT LALAAANACF
NPLLYYFAGE NFKDRLKSAL RKGHPQKAKT KCVFPVSVWL RKETRV
