CLTR2_MOUSE
ID CLTR2_MOUSE Reviewed; 309 AA.
AC Q920A1; A2RT90;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Cysteinyl leukotriene receptor 2;
DE Short=CysLTR2;
GN Name=Cysltr2; Synonyms=Cyslt2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Heart;
RX PubMed=11591709; DOI=10.1074/jbc.m107556200;
RA Hui Y., Yang G., Galczenski H., Figueroa D.J., Austin C.P., Copeland N.G.,
RA Gilbert D.J., Jenkins N.A., Funk C.D.;
RT "The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic
RT cloning, alternative splicing, and in vitro characterization.";
RL J. Biol. Chem. 276:47489-47495(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for cysteinyl leukotrienes. The response is mediated
CC via a G-protein that activates a phosphatidylinositol-calcium second
CC messenger system. The rank order of affinities for the leukotrienes is
CC LTC4 = LTD4 >> LTE4.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Widely expressed at low levels, with highest
CC expression in the spleen, thymus and adrenal gland, and lower in the
CC kidney, brain and peripheral blood leukocytes.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF331658; AAK97354.1; -; mRNA.
DR EMBL; CH466535; EDL35864.1; -; Genomic_DNA.
DR EMBL; CH466535; EDL35865.1; -; Genomic_DNA.
DR EMBL; BC132414; AAI32415.1; -; mRNA.
DR EMBL; BC132418; AAI32419.1; -; mRNA.
DR CCDS; CCDS27265.1; -.
DR RefSeq; NP_001155884.1; NM_001162412.1.
DR RefSeq; NP_598481.2; NM_133720.3.
DR RefSeq; XP_011243480.1; XM_011245178.2.
DR AlphaFoldDB; Q920A1; -.
DR SMR; Q920A1; -.
DR STRING; 10090.ENSMUSP00000040715; -.
DR GlyGen; Q920A1; 1 site.
DR PhosphoSitePlus; Q920A1; -.
DR MaxQB; Q920A1; -.
DR PaxDb; Q920A1; -.
DR PRIDE; Q920A1; -.
DR ProteomicsDB; 285498; -.
DR DNASU; 70086; -.
DR Ensembl; ENSMUST00000044664; ENSMUSP00000040715; ENSMUSG00000033470.
DR Ensembl; ENSMUST00000169168; ENSMUSP00000125958; ENSMUSG00000033470.
DR GeneID; 70086; -.
DR KEGG; mmu:70086; -.
DR UCSC; uc007upi.2; mouse.
DR CTD; 57105; -.
DR MGI; MGI:1917336; Cysltr2.
DR VEuPathDB; HostDB:ENSMUSG00000033470; -.
DR eggNOG; ENOG502RX8K; Eukaryota.
DR GeneTree; ENSGT00990000203619; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q920A1; -.
DR OMA; CMLSICY; -.
DR OrthoDB; 930634at2759; -.
DR PhylomeDB; Q920A1; -.
DR TreeFam; TF350009; -.
DR Reactome; R-MMU-163359; Glucagon signaling in metabolic regulation.
DR Reactome; R-MMU-391906; Leukotriene receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-420092; Glucagon-type ligand receptors.
DR BioGRID-ORCS; 70086; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q920A1; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q920A1; protein.
DR Bgee; ENSMUSG00000033470; Expressed in secondary oocyte and 46 other tissues.
DR Genevisible; Q920A1; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0001631; F:cysteinyl leukotriene receptor activity; IDA:MGI.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
DR GO; GO:0010942; P:positive regulation of cell death; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR InterPro; IPR013311; CLT2_recept.
DR InterPro; IPR004071; Cyst_leuk_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01903; CYSLT2RECPTR.
DR PRINTS; PR01533; CYSLTRECPTR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..309
FT /note="Cysteinyl leukotriene receptor 2"
FT /id="PRO_0000069304"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..171
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 122
FT /note="L -> Q (in Ref. 1; AAK97354)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 309 AA; 35213 MW; BA8B055A00D1CBFE CRC64;
MEVTGTPSSY SNRNCTIENF KKEFYPIIYL IIFFWGALGN GFSIYVFLQT CKKSTSVNVF
MLNLATSDFL FISTLPFRAD YYFRGSNWIF GDLACRVMSY SLYVNMYTSI YFLTVLSVVR
FLATVHPFRM FHVTSVRSAW ILCGIIWVFI MASSALLLVN GQEEKDNIIS CLELSPQKFK
SLLIMNHIAV AVGFLLPFLT LTVCYLLIIR ILLKAEIPES GPRAAHRKAL TTIVIAMITF
LLCFLPYHAL RTLHLVTWDK DSCGDVLHKA TVITLTMAAA NSCFNPFLYY FAGENFKARL
RAIFSKVHL
