CLTR2_RAT
ID CLTR2_RAT Reviewed; 309 AA.
AC Q924T9;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Cysteinyl leukotriene receptor 2;
DE Short=CysLTR2;
DE AltName: Full=RSBPT32;
GN Name=Cysltr2; Synonyms=Cyslt2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kamohara M., Takasaki J., Matsumoto M., Matsumoto S., Saito T., Ohishi T.,
RA Soga T., Matsushime H., Furuichi K.;
RT "Characterization of the cloned rat and porcine cysteinyl leukotriene
RT receptors.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for cysteinyl leukotrienes. The response is mediated
CC via a G-protein that activates a phosphatidylinositol-calcium second
CC messenger system (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB052661; BAB60816.1; -; mRNA.
DR RefSeq; NP_596904.1; NM_133413.1.
DR RefSeq; XP_008769065.1; XM_008770843.2.
DR AlphaFoldDB; Q924T9; -.
DR SMR; Q924T9; -.
DR STRING; 10116.ENSRNOP00000020187; -.
DR GuidetoPHARMACOLOGY; 270; -.
DR GlyGen; Q924T9; 3 sites.
DR PhosphoSitePlus; Q924T9; -.
DR PaxDb; Q924T9; -.
DR Ensembl; ENSRNOT00000101826; ENSRNOP00000095936; ENSRNOG00000067464.
DR Ensembl; ENSRNOT00000102995; ENSRNOP00000083658; ENSRNOG00000067464.
DR Ensembl; ENSRNOT00000105845; ENSRNOP00000091083; ENSRNOG00000067464.
DR Ensembl; ENSRNOT00000112031; ENSRNOP00000083081; ENSRNOG00000067464.
DR Ensembl; ENSRNOT00000115019; ENSRNOP00000087467; ENSRNOG00000067464.
DR GeneID; 170926; -.
DR KEGG; rno:170926; -.
DR UCSC; RGD:619797; rat.
DR CTD; 57105; -.
DR RGD; 619797; Cysltr2.
DR eggNOG; ENOG502RX8K; Eukaryota.
DR GeneTree; ENSGT00990000203619; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q924T9; -.
DR OMA; CMLSICY; -.
DR OrthoDB; 930634at2759; -.
DR PhylomeDB; Q924T9; -.
DR TreeFam; TF350009; -.
DR Reactome; R-RNO-163359; Glucagon signaling in metabolic regulation.
DR Reactome; R-RNO-391906; Leukotriene receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-420092; Glucagon-type ligand receptors.
DR PRO; PR:Q924T9; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Bgee; ENSRNOG00000015042; Expressed in thymus and 10 other tissues.
DR Genevisible; Q924T9; RN.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0001631; F:cysteinyl leukotriene receptor activity; ISO:RGD.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:RGD.
DR GO; GO:0010942; P:positive regulation of cell death; IMP:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:RGD.
DR InterPro; IPR013311; CLT2_recept.
DR InterPro; IPR004071; Cyst_leuk_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01903; CYSLT2RECPTR.
DR PRINTS; PR01533; CYSLTRECPTR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..309
FT /note="Cysteinyl leukotriene receptor 2"
FT /id="PRO_0000069306"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..137
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 14
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..171
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 309 AA; 35507 MW; A122AC8177879D56 CRC64;
MGVTGTPSYY SDKNCTIENF KRDFYPIIYL IIFVWGALGN GFSIYVFLQT YKKSTSVNVF
MLNLAISDFL FISTLPFRAD YNFRGSDWIF GDWACRIMSY SLYVNMYTSI YFLTVLSIVR
FLATAHPFQM LHITSVRSAW ILCGIIWVFI MASSGLLLKH GQEKKNNTTL CFELNLQKFK
NLVILNYIAL GVGFLLPFFI LTICYLLIIR VLLKVEIPES GPRDAQRKAL TTIVIAMIIF
LLCFLPYHAL RTIHLVTWDA DSCMDELHKA TVITLTLAAA NSCFNPFLYY FAGENFKARL
RAIFSKDHL
