ID   CLTX_CELWA              Reviewed;         185 AA.
AC   E2E4F7; E2E4F8;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Celestoxin;
DE   Flags: Precursor;
OS   Celestus warreni (Giant Hispaniolan galliwasp) (Diploglossus warreni).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Diploglossidae; Caribicus.
OX   NCBI_TaxID=865857;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS CELESTOXIN-1 AND CELESTOXIN-2),
RP   SYNTHESIS OF 153-185, AND FUNCTION.
RC   STRAIN=Haiti; TISSUE=Venom gland;
RX   PubMed=20631207; DOI=10.1074/mcp.m110.001370;
RA   Fry B.G., Winter K., Norman J.A., Roelants K., Nabuurs R.J., van Osch M.J.,
RA   Teeuwisse W.M., van der Weerd L., McNaughtan J.E., Kwok H.F., Scheib H.,
RA   Greisman L., Kochva E., Miller L.J., Gao F., Karas J., Scanlon D., Lin F.,
RA   Kuruppu S., Shaw C., Wong L., Hodgson W.C.;
RT   "Functional and structural diversification of the Anguimorpha lizard venom
RT   system.";
RL   Mol. Cell. Proteomics 9:2369-2390(2010).
CC   -!- FUNCTION: Has a hypotensive activity. {ECO:0000269|PubMed:20631207}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Celestoxin-1;
CC         IsoId=E2E4F7-1; Sequence=Displayed;
CC       Name=Celestoxin-2;
CC         IsoId=E2E4F7-2; Sequence=VSP_041809;
CC   -!- TISSUE SPECIFICITY: Expressed by the mandibular venom gland.
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DR   EMBL; GU441474; ADK39238.1; -; mRNA.
DR   EMBL; GU441475; ADK39239.1; -; mRNA.
DR   AlphaFoldDB; E2E4F7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Hypotensive agent; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..148
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000412827"
FT   CHAIN           153..185
FT                   /note="Celestoxin"
FT                   /id="PRO_0000412828"
FT   VAR_SEQ         135..146
FT                   /note="Missing (in isoform Celestoxin-2)"
FT                   /evidence="ECO:0000303|PubMed:20631207"
FT                   /id="VSP_041809"
SQ   SEQUENCE   185 AA;  18278 MW;  F7EF578DC0D7AF9B CRC64;
     MKFIAAVLLV ALLCPKDSTS LASRLSGLLG GDGILGGSGL LGGLGKIPLG GRLLGGRPDD
     VLREDDVLGE VGGRPDDVLG EVGGRPDDVL GEVGGRPDDG LGELGGGPNR LFGGSRLFGG
     VEKVVAGIPL PNVADVAGGL PVALPVSVRR RRALGVVGGL PVPKLPGVAG GLPVPKLPVP
     LPVNL