ID   CLUA1_MACFA             Reviewed;         414 AA.
AC   Q4R6Y7;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Clusterin-associated protein 1;
GN   Name=CLUAP1; ORFNames=QtsA-16846;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for cilia biogenesis. Appears to function within the
CC       multiple intraflagellar transport complex B (IFT-B). Key regulator of
CC       hedgehog signaling. {ECO:0000250|UniProtKB:Q8R3P7}.
CC   -!- SUBUNIT: Interacts with CLU/clusterin. Interacts with UBXN10; the
CC       interaction is direct. {ECO:0000250|UniProtKB:Q96AJ1}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96AJ1}. Nucleus {ECO:0000250|UniProtKB:Q96AJ1}.
CC   -!- SIMILARITY: Belongs to the CLUAP1 family. {ECO:0000305}.
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DR   EMBL; AB169043; BAE01137.1; -; mRNA.
DR   RefSeq; NP_001272094.1; NM_001285165.1.
DR   AlphaFoldDB; Q4R6Y7; -.
DR   SMR; Q4R6Y7; -.
DR   STRING; 9541.XP_005591143.1; -.
DR   GeneID; 101866465; -.
DR   CTD; 23059; -.
DR   eggNOG; KOG3647; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   InterPro; IPR019366; Clusterin-associated_protein-1.
DR   PANTHER; PTHR21547; PTHR21547; 1.
DR   Pfam; PF10234; Cluap1; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..414
FT                   /note="Clusterin-associated protein 1"
FT                   /id="PRO_0000239452"
FT   REGION          305..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          198..291
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        361..388
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..414
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         314
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R3P7"
FT   MOD_RES         324
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R3P7"
FT   MOD_RES         326
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R3P7"
FT   MOD_RES         410
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96AJ1"
SQ   SEQUENCE   414 AA;  48238 MW;  D6FD438B457BA36E CRC64;
     MSFRDLRNFT EMMRALGYPR HISMENLRTP NFGLVSEVLL WLVKRYEPQT DIPPDVDTEQ
     DRVFFIKAIA QFMATKAHIK LNTKKLYQAD GYAVKELLKI TSVLYNAMKT KGMEGSEIVE
     EDVNKFKFDL GSKIADLKAA RQLASEITSK GASLYDLLGM EVELREMRTE AIARPLEINE
     TEKVMRIAIK EILTQVQKTK DLLNNVASDE ANLEAKIEKR KLELERNRKR LETLQSVRPC
     FMDEYEKTEE ELQKQYDIYL EKFQNLTYLE QQLEEHHRME QERFEEAKNT LCLIQNKLKE
     EEKRLLKSGS NDDSDVDIQE DDESDSELEE RRLPKPRTAM EVLMQGRPGK RIVGTMQGGD
     SDDNEDSEES EIDMEDDDED EDDDLEDESI SLSPTKPNRR VRKPEPLDES DNDF