ID   CLUA1_RAT               Reviewed;         402 AA.
AC   Q6AYJ5;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Clusterin-associated protein 1;
GN   Name=Cluap1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303 AND SER-398, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Required for cilia biogenesis. Appears to function within the
CC       multiple intraflagellar transport complex B (IFT-B). Key regulator of
CC       hedgehog signaling. {ECO:0000250|UniProtKB:Q8R3P7}.
CC   -!- SUBUNIT: Interacts with CLU/clusterin. Interacts with UBXN10; the
CC       interaction is direct. {ECO:0000250|UniProtKB:Q96AJ1}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q96AJ1}. Nucleus {ECO:0000250|UniProtKB:Q96AJ1}.
CC   -!- SIMILARITY: Belongs to the CLUAP1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC079022; AAH79022.1; -; mRNA.
DR   RefSeq; NP_001014247.1; NM_001014225.1.
DR   AlphaFoldDB; Q6AYJ5; -.
DR   SMR; Q6AYJ5; -.
DR   STRING; 10116.ENSRNOP00000062395; -.
DR   iPTMnet; Q6AYJ5; -.
DR   PhosphoSitePlus; Q6AYJ5; -.
DR   PaxDb; Q6AYJ5; -.
DR   PRIDE; Q6AYJ5; -.
DR   Ensembl; ENSRNOT00000064964; ENSRNOP00000062395; ENSRNOG00000007117.
DR   GeneID; 363544; -.
DR   KEGG; rno:363544; -.
DR   UCSC; RGD:1359189; rat.
DR   CTD; 23059; -.
DR   RGD; 1359189; Cluap1.
DR   eggNOG; KOG3647; Eukaryota.
DR   GeneTree; ENSGT00390000008957; -.
DR   InParanoid; Q6AYJ5; -.
DR   OrthoDB; 874966at2759; -.
DR   PhylomeDB; Q6AYJ5; -.
DR   Reactome; R-RNO-5620924; Intraflagellar transport.
DR   PRO; PR:Q6AYJ5; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000007117; Expressed in testis and 20 other tissues.
DR   ExpressionAtlas; Q6AYJ5; baseline and differential.
DR   Genevisible; Q6AYJ5; RN.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0097546; C:ciliary base; ISO:RGD.
DR   GO; GO:0097542; C:ciliary tip; ISO:RGD.
DR   GO; GO:0005929; C:cilium; ISO:RGD.
DR   GO; GO:0030991; C:intraciliary transport particle A; ISO:RGD.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0035082; P:axoneme assembly; ISO:RGD.
DR   GO; GO:0060271; P:cilium assembly; ISO:RGD.
DR   GO; GO:0021508; P:floor plate formation; ISO:RGD.
DR   GO; GO:0001947; P:heart looping; ISO:RGD.
DR   GO; GO:0060972; P:left/right pattern formation; ISO:RGD.
DR   GO; GO:0001843; P:neural tube closure; ISO:RGD.
DR   GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR   InterPro; IPR019366; Clusterin-associated_protein-1.
DR   PANTHER; PTHR21547; PTHR21547; 1.
DR   Pfam; PF10234; Cluap1; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..402
FT                   /note="Clusterin-associated protein 1"
FT                   /id="PRO_0000239454"
FT   REGION          292..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          187..297
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        348..376
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..402
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         303
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         313
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R3P7"
FT   MOD_RES         315
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R3P7"
FT   MOD_RES         398
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   402 AA;  46572 MW;  AF48B41E7BD7C4FE CRC64;
     MMRALGYPRH ISMENFRTPN FGLVSEVLLW LVKRYEPQTD IPSDTETEQD RVFFIKAIAQ
     FMATKAHIKL NTKKLYQADG YAVKELLKIT SVLYNAMKTK GMEGSNVGEE DISKFKFDLG
     SKIADLKAAR QLASEITAKG ASLYDLLGKE VELRELRTEA IARPLEINET EKVMRIAIKD
     ILAQVQKTKD LLNNVASDEA NLEAKIEKRK LELERNRKRL QTLQSVRPAF MDEYEKVEEE
     LQKQYDVYLE KFRNLAYLEQ QLEDHHRMEQ ERFEEAENTL RLMQNKLKEE EKRLLKSGSN
     DDSDIDIQED DESDSELEDR RLSKPRTAME VLMQGRPSKR IVGTMQGGDS DEDEDSEDSE
     MNMEDDEEDD DDLEDESIAL SPAKPSRRVR KPEPLDESDN DF