CLUL1_HUMAN
ID CLUL1_HUMAN Reviewed; 466 AA.
AC Q15846; A0FDN7;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Clusterin-like protein 1;
DE AltName: Full=Retinal-specific clusterin-like protein;
DE Flags: Precursor;
GN Name=CLUL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14507903; DOI=10.1167/iovs.02-1202;
RA Zhang Q., Beltran W.A., Mao Z., Li K., Johnson J.L., Acland G.M.,
RA Aguirre G.D.;
RT "Comparative analysis and expression of CLUL1, a cone photoreceptor-
RT specific gene.";
RL Invest. Ophthalmol. Vis. Sci. 44:4542-4549(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Neuroretina;
RA Shimizu A., Nishida K., Kinoshita S., Inazawa J., Okubo K., Matsubara K.;
RT "Expression profile of active genes in human retina.";
RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-17.
RC TISSUE=Retina;
RX PubMed=17286855; DOI=10.1186/1471-2164-8-42;
RA Roni V., Carpio R., Wissinger B.;
RT "Mapping of transcription start sites of human retina expressed genes.";
RL BMC Genomics 8:42-42(2007).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the clusterin family. {ECO:0000305}.
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DR EMBL; AF395889; AAM73723.1; -; mRNA.
DR EMBL; D63813; BAA09882.1; -; mRNA.
DR EMBL; BC025381; AAH25381.1; -; mRNA.
DR EMBL; DQ980621; ABJ97142.1; -; mRNA.
DR CCDS; CCDS42405.1; -.
DR CCDS; CCDS74187.1; -.
DR RefSeq; NP_001275965.1; NM_001289036.1.
DR RefSeq; NP_001305451.1; NM_001318522.1.
DR RefSeq; NP_055225.1; NM_014410.4.
DR RefSeq; NP_954636.1; NM_199167.1.
DR RefSeq; XP_011523954.1; XM_011525652.1.
DR RefSeq; XP_011523955.1; XM_011525653.2.
DR AlphaFoldDB; Q15846; -.
DR SMR; Q15846; -.
DR BioGRID; 117999; 1.
DR STRING; 9606.ENSP00000441726; -.
DR GlyGen; Q15846; 6 sites.
DR iPTMnet; Q15846; -.
DR PhosphoSitePlus; Q15846; -.
DR BioMuta; CLUL1; -.
DR DMDM; 78099959; -.
DR EPD; Q15846; -.
DR jPOST; Q15846; -.
DR MassIVE; Q15846; -.
DR PaxDb; Q15846; -.
DR PeptideAtlas; Q15846; -.
DR PRIDE; Q15846; -.
DR ProteomicsDB; 60789; -.
DR Antibodypedia; 21905; 95 antibodies from 21 providers.
DR DNASU; 27098; -.
DR Ensembl; ENST00000338387.11; ENSP00000341128.6; ENSG00000079101.17.
DR Ensembl; ENST00000400606.6; ENSP00000383449.2; ENSG00000079101.17.
DR Ensembl; ENST00000579494.1; ENSP00000464642.1; ENSG00000079101.17.
DR Ensembl; ENST00000692774.1; ENSP00000510271.1; ENSG00000079101.17.
DR GeneID; 27098; -.
DR KEGG; hsa:27098; -.
DR MANE-Select; ENST00000692774.1; ENSP00000510271.1; NM_001393344.1; NP_001380273.1.
DR UCSC; uc002kkp.4; human.
DR CTD; 27098; -.
DR DisGeNET; 27098; -.
DR GeneCards; CLUL1; -.
DR HGNC; HGNC:2096; CLUL1.
DR HPA; ENSG00000079101; Tissue enriched (retina).
DR MIM; 616990; gene.
DR neXtProt; NX_Q15846; -.
DR OpenTargets; ENSG00000079101; -.
DR PharmGKB; PA26621; -.
DR VEuPathDB; HostDB:ENSG00000079101; -.
DR eggNOG; ENOG502QQ44; Eukaryota.
DR GeneTree; ENSGT00530000063668; -.
DR HOGENOM; CLU_042162_0_0_1; -.
DR InParanoid; Q15846; -.
DR PhylomeDB; Q15846; -.
DR TreeFam; TF333030; -.
DR PathwayCommons; Q15846; -.
DR BioGRID-ORCS; 27098; 17 hits in 1063 CRISPR screens.
DR ChiTaRS; CLUL1; human.
DR GenomeRNAi; 27098; -.
DR Pharos; Q15846; Tdark.
DR PRO; PR:Q15846; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q15846; protein.
DR Bgee; ENSG00000079101; Expressed in pigmented layer of retina and 123 other tissues.
DR ExpressionAtlas; Q15846; baseline and differential.
DR Genevisible; Q15846; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR InterPro; IPR000753; Clusterin-like.
DR InterPro; IPR016015; Clusterin_C.
DR InterPro; IPR016014; Clusterin_N.
DR PANTHER; PTHR10970; PTHR10970; 1.
DR Pfam; PF01093; Clusterin; 1.
DR SMART; SM00035; CLa; 1.
DR SMART; SM00030; CLb; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Disulfide bond; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..466
FT /note="Clusterin-like protein 1"
FT /id="PRO_0000005552"
FT COILED 57..111
FT /evidence="ECO:0000255"
FT CARBOHYD 196
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 311
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 412
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 431
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..333
FT /evidence="ECO:0000250"
FT DISULFID 116..325
FT /evidence="ECO:0000250"
FT DISULFID 119..322
FT /evidence="ECO:0000250"
FT DISULFID 124..315
FT /evidence="ECO:0000250"
FT DISULFID 131..305
FT /evidence="ECO:0000250"
SQ SEQUENCE 466 AA; 54215 MW; 41A603D0FD6439C4 CRC64;
MKPPLLVFIV CLLWLKDSHC APTWKDKTAI SENLKSFSEV GEIDADEEVK KALTGIKQMK
IMMERKEKEH TNLMSTLKKC REEKQEALKL LNEVQEHLEE EERLCRESLA DSWGECRSCL
ENNCMRIYTT CQPSWSSVKN KIERFFRKIY QFLFPFHEDN EKDLPISEKL IEEDAQLTQM
EDVFSQLTVD VNSLFNRSFN VFRQMQQEFD QTFQSHFISD TDLTEPYFFP AFSKEPMTKA
DLEQCWDIPN FFQLFCNFSV SIYESVSETI TKMLKAIEDL PKQDKAPDHG GLISKMLPGQ
DRGLCGELDQ NLSRCFKFHE KCQKCQAHLS EDCPDVPALH TELDEAIRLV NVSNQQYGQI
LQMTRKHLED TAYLVEKMRG QFGWVSELAN QAPETEIIFN SIQVVPRIHE GNISKQDETM
MTDLSILPSS NFTLKIPLEE SAESSNFIGY VVAKALQHFK EHFKTW
