CLU_AEDAE
ID CLU_AEDAE Reviewed; 1442 AA.
AC Q17N71;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN ORFNames=AAEL000794;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH477201; EAT48183.1; -; Genomic_DNA.
DR RefSeq; XP_001651007.1; XM_001650957.1.
DR AlphaFoldDB; Q17N71; -.
DR SMR; Q17N71; -.
DR STRING; 7159.AAEL000794-PA; -.
DR VEuPathDB; VectorBase:AAEL027504; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; Q17N71; -.
DR OMA; VSGFYVN; -.
DR PhylomeDB; Q17N71; -.
DR Proteomes; UP000008820; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1442
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366376"
FT DOMAIN 394..636
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1087..1120
FT /note="TPR 1"
FT REPEAT 1213..1246
FT /note="TPR 2"
FT REPEAT 1248..1281
FT /note="TPR 3"
FT REGION 38..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1425..1442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1442 AA; 161577 MW; CAFFFF5462945B9E CRC64;
MQFLSPQMEQ KLHRATIHQI TVSKTGDMPI RFRLRHLNYR NNKKQKNGKD KETTPPPTTT
GAKEPLVNGH SAAVNGMNGH TSEGEQQKDK TAAEDKKKPD SDVMEIIQDT GFTVQILSPG
VEPLSIQVSS MELVQEIHQL LMDREDTCHR TCFSLQLDGV TLDNFAELKN IEGLKEGSII
KVVEEPYTMR EARIHVRHVR DLLKSMDPAD AYNGVDCSSL TFLHTITQGD ILEKKKGRSE
SVDCTPPEHI MPGAKDRPLL PLQPGVGKKG PQPLKVLTTS AWNPPPGPRK LHGDLMYLYV
VTMEDKRFHI SACPRGFFIN QSSDDVFDPR PDNPSYLCHS LIDLLSQISP TFRRCFAQMQ
KKRTQRHPFE RVATPYQVYT WSAPALEHTI DAIRAEDTFS SKLGYEEHIP GQTRDWNEEL
QTTRELPRET LPERLLRERA IFKVHSDFVT AATRGAMAVI DGNVMAINPG EDAKMQMFIW
NNIFFSLGFD VRDHYKELGG DAAAFVAPRN DLHGVRVYSA VDVEGLYTLG TVVIDYRGYR
VTAQSIIPGI LEREQEQSVV YGSIDFGKTV LSHEKYLELL NNAGKHLKIL PHSVLNEKEE
EIELCSSVEC KGIIGNDGRH YILDLLRTFP PDVNFLKLDE ELSKDCKALG FPIEHKHKLS
CLRQELLEAF VESRYLMFIK HAAFQLQQLN SAKLKQKQEA KDSKDSEKKE EPKAIEAAPV
AKEPAKKDAA ESNNNVESKE ECPKKGSTDK AKDKSAGVPK VETEEAKKLM ESLLSSDEKN
ESKEVVKRAC EAVGSLKEYE FDIRFNPDVY SPGIKHVDNQ SAANSLKKQK QLVKDAAEFL
VKHQIPSFVH DCLDHTAAPM DGTTLTETLH SRGINVRYLG KVANLLAKIK QLEYLHTIAV
SELIIRAAKH IFTSYMQNTE MMSMAAAISH FLNCFLTATT AVSHSGSLSE SDALTKSGSS
GGKQQRRQNK RSAGSKGGKP SFQCTQDNNE WQLLTPKSLW SQIEKELKSY WDYELLPAGA
HDSADPVVSH YRLQKISLLR AFCLKTGVQI LLREYNFEMK NKPTFGESDI VNVFPVVKHI
NPRASDAYNF YTTGQSKIQQ GYFKDGYDLI SEALNLLNNV YGAMHPENAQ CLRMLARLSY
IMGDPQEALA IQQRAVLMSE RVNGIDHPYT IAEYAPLALY CFANSQISTA LKLLYRARYL
ATIVCGENHP DIALLDSNIS LILHAVGEYE LSLRFLEHAL ALNIKYYGEK SLKVAVSYHL
VARTQSCMGD FRSALNNEKE TYAIYKQQLG ETHEKTQESS ECLRHLTQQA VVLQKKMNDI
YSNGKLTSGL PPIHIQPPSM GSVLDMLNAI NGIIFVQISS KEIANLKNEI EKRQKEGGTS
EQAAAAQASQ EEVDRMLTET MAKTAAGIPF EDHDKHELPV AAEASSSKQA DNSSNASAQQ
VS
