CLU_AJECN
ID CLU_AJECN Reviewed; 1237 AA.
AC A6R8I2;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=HCAG_06623;
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC unclassified Histoplasma.
OX NCBI_TaxID=2059318;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH476660; EDN09456.1; -; Genomic_DNA.
DR RefSeq; XP_001539018.1; XM_001538968.1.
DR AlphaFoldDB; A6R8I2; -.
DR SMR; A6R8I2; -.
DR STRING; 339724.A6R8I2; -.
DR PRIDE; A6R8I2; -.
DR EnsemblFungi; EDN09456; EDN09456; HCAG_06623.
DR GeneID; 5445630; -.
DR KEGG; aje:HCAG_06623; -.
DR VEuPathDB; FungiDB:HCAG_06623; -.
DR HOGENOM; CLU_003256_2_0_1; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1237
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366391"
FT DOMAIN 291..535
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 957..990
FT /note="TPR 1"
FT REPEAT 999..1032
FT /note="TPR 2"
FT REPEAT 1041..1074
FT /note="TPR 3"
FT REGION 575..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..877
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1237 AA; 138090 MW; 913C1D0D57EB8FE2 CRC64;
MTEISVKLPH EPYNIQVTVS SQEQVQDVRQ SIVELPGTFQ YTSFHLEHNG TRINDYIELS
EVKDIQANSE VVLVEDPYTE KEARMHVIRI RELIGAAGDR VDNLHGICAG LSLHDSVAAG
EQLTDTKEGE RGVVRDHALV DYDMTAPPVL QTILPRAQPS LPKTVKAISL SPWNPPPYHL
RQRGHLLYLQ VTTNEGEQHQ ITSHVSGFFV NKSSNAKFDP FPRPAPKNYS AHSLLTLISM
LSPSFDASFK ALQESNNKKD LLTTFPFQNS IPKNPWLVPP TSSAVTAHQS DITRSQENCL
IFGVDNSETL RDWNEEFQST RELPRETVQD KVSRERLTSK LFADYNDAAA RGAVLVAKGE
IAPLNPTEGK DAQIFVYNNI FFSFGADGVG TFASEGGDEA ARVAVGKDVV GAKAVNQLDI
PGLFTPGTVV VDYLGKRLVG QSIVPGIFKQ REPGEHQIDY GGVEGKEVVA EHKDFVPVFE
KLSASLRVKK HPVWDKEGKR HDLEGSVETK GLLGTDGRKY VLDLYRITPL DVAWSEDAEG
HEPYPHRMSV LRLELVELYW RYKMGQYVKA EVQKRKTAKR EAEKTKAVEA QNEDKAELLS
TSDPGEGENK AVASEQERVD ISAFKLALNP DVFSGQVPQT DEEKEEWAQD EKEVRSACDH
LISKVIPELI QDLHDGDVGF PMDGESLTQL LHKRGINVRY LGKLAKLSQA KGQRLLALTA
LLIQEMVSRS FKHIANRYLR YLPSPFTASC VSHLLNCFLG AEVNSNPRPE IDEELREIYP
EGDFSFEKVT PTSLKGDIEK QIKIRFRFNL EPKWTSSLKH LQLLRDISIK LGLQIGAREF
AFERSQIKSQ EHSPEPSSTH SSQDERGKRK KKKGSNSDSP SRVAASPRPV VTFVPEDILN
IVPLVKDASP RSALAEEALE AGRISIMQNQ KEIGQELILE SLSLHEQIYG ILHPEVAKLY
HQLSMLYYQT DEKEAAVELA RKAVIVTERT MGVDSADTIL SYLNLSLFEH ASGNTHTALI
YIRHALELWK IIYGSHHPDS ITTMNNAAVM LQHLKKYPDS RKWFEASLTV CEGLFGRQSI
NTATILFQLA QALALDQDSK AAVNRMRDAY NIFLNELGPN DRNTKEAESW LEQLTQNAVS
IAKHAKDIQA RRLRRTNLSP RMTIGTKPQP QVGQNAPATT NGATSKSIGL DSRSIDELLK
FIEGGGESRS PRSKQKKRAA ASNPKLRGSK QSTVQTA
