CLU_ANOGA
ID CLU_ANOGA Reviewed; 1463 AA.
AC Q7PZD5;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 4.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN ORFNames=AGAP011851;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; AAAB01008986; EAA00110.4; -; Genomic_DNA.
DR RefSeq; XP_320668.4; XM_320668.4.
DR AlphaFoldDB; Q7PZD5; -.
DR SMR; Q7PZD5; -.
DR STRING; 7165.AGAP011851-PA; -.
DR PaxDb; Q7PZD5; -.
DR PRIDE; Q7PZD5; -.
DR GeneID; 1280801; -.
DR KEGG; aga:AgaP_AGAP011851; -.
DR CTD; 1280801; -.
DR VEuPathDB; VectorBase:AGAP029760; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; Q7PZD5; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 23544at2759; -.
DR PhylomeDB; Q7PZD5; -.
DR Proteomes; UP000007062; Chromosome 3L.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 2.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..1463
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366377"
FT DOMAIN 374..616
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1387..1463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..731
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1463 AA; 161109 MW; 1E57383D83A3DA0D CRC64;
MAKNKKQNGK AKTPPVVAAA AGEQKETIGN GHAEQNGLNG HASSEESDPA AAGPNESADD
KSAGVAGGGE TEQQQQQQED DVMRLMQETG FTVQVLSPGV EPLSIQVSSM ELVQEIHQLL
MDREDTCHRT CFSLQLDGRT LDNFAELKNI DGLQEGSVIR VVEEPYTMRE ARIHVRHVRD
LLKSLDPADA YNGVDCSSLT FLHTITMGDI MEKKKTRQES VDCTPPDFIM PGARERPLLP
LQPGTGKKGT PQPLKVLTTS AWNPPPGPRK LHGDLMYLYV VTMEDKRLHI SACSRGFYVN
QSTDDAFNPQ PANPSYLSHS LIDLLSQISA TFRRCFAQMQ KKRTQRHPFE RVATPYQVYT
WTAPALEHTI DAIRAEDTFS SKLGYEEHIP GQTRDWNEEL QTTRELPRAT LPERLLRERA
IFKVHSDFVT AATRGAMAVI DGNVMPINPG EDAKTQMFIW NNIFFSLGFD VRDHYKELGG
DAAAFVAPRN DLHGVRVYSA VDVEGLYTLG TVVIDYRGYR VTAQSIIPGI LEREQDQSVV
YGSIDFGKTV LSHPKYLELL NAAGKHLKIL PHSVYNDKEE AIELCSSVEC KGIIGNDGRH
YILDLLRTFP PDVNFLALPA EEEAVGKESR AMGFPIEHRH KLCCLRQELL EAFVENRYLM
FMKHAAVQLQ QCVKMKQEQK AAAAQKTEEG GKQAAIEAAA PAEGDKTPAK DAKDGKEAGK
DANDGKEEGS TTKEAAAAAA AARSVPKPDS EDAKKLVESL ISSDQKNESM EVVKRACEAV
GSLKEYEFNI RFNPDVYSPG IRHVDEEPNA AGSLRRQKQL VKDAAEFLVK HQIPSFVHEC
LDHTSAPMDG VTLTELLHNR GINVRYLGKV VDQLAKIKQL EYLHTIAVSE LIVRAAKHLF
TAYLQQTDVM SMAAAISHFL NCFLTVSTGG YQPVANGTGA DGDGQLADEF GPKAGGKKQN
KQSKRGGGGG GGKGAAGGGR KATFSVPSSD NCEWTALTSK TLWAQIRQEL KAYWDFELTV
EQPAKEGKES KAAVIDSIEP LIGAFKLQKI SLLRSFCLKT GVQILLQEYA FEQRNRPAFT
DADIVNVFPV VKHINPRASD AYNFYTTGQT KIQQGYLQDG YGLISEALNL LNNVYGAMHP
ENAQCLRMLA RLSYIMGDPQ EALAIQQRAV LMSERVNGVD HPYTISEYGH LALYCFANSQ
ITTALKLLYR ARYLATIVCG ENHPDIALMD SNISLILHAV GEYELSLRFL EHALALNIRY
YGEKSLKVAV SYHLVARTQS CMGDFRSALV NEKETYAIYK QQLGENHEKT QESSECLRHL
TQQAVVLQKK MNYANGKLLS TGLPPIHIQP PSMGSVLDML NAINGIIFVQ ISSKEIANFK
NEIEKRQKEA GAQSQQPGGG PVQANQEEVD QMLMETMQKT AAGIPFEEQD GEKKDGAAEA
ASHTAGGAAA NTAAPAVSPR RKS
