CLU_ASHGO
ID CLU_ASHGO Reviewed; 1228 AA.
AC Q75DR9;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=CLU1 {ECO:0000255|HAMAP-Rule:MF_03013};
GN Synonyms=TIF31 {ECO:0000255|HAMAP-Rule:MF_03013};
GN OrderedLocusNames=ABR050W; ORFNames=AGOS_ABR050W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 439; 442-452; 905-906; 927;
RP 930; 952; 954; 961 AND 966.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; AE016815; AAS50820.2; -; Genomic_DNA.
DR RefSeq; NP_982996.2; NM_208349.2.
DR AlphaFoldDB; Q75DR9; -.
DR SMR; Q75DR9; -.
DR STRING; 33169.AAS50820; -.
DR EnsemblFungi; AAS50820; AAS50820; AGOS_ABR050W.
DR GeneID; 4619000; -.
DR KEGG; ago:AGOS_ABR050W; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR InParanoid; Q75DR9; -.
DR OMA; VSGFYVN; -.
DR Proteomes; UP000000591; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0048312; P:intracellular distribution of mitochondria; IBA:GO_Central.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR Gene3D; 3.30.2280.10; -; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1228
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366392"
FT DOMAIN 298..557
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 486..519
FT /note="TPR 1"
FT REPEAT 982..1015
FT /note="TPR 2"
FT REPEAT 1108..1141
FT /note="TPR 3"
FT COILED 671..702
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03013"
SQ SEQUENCE 1228 AA; 137804 MW; 55146B729B083351 CRC64;
MSKELDTVEV SIRVPFGKSK RLSTTASRRA RVQSIMYFLA FNAASKYYTN YELLHNGVEV
DEQQLISELA GNEQTVHLQL RLKPYNTGEV IRHFVTFREY IGFVGDSDDD ITSLALSNVA
KFRELPLTDI AAASGKTEVA DDRQKEEFQV SDAEKAVFTK ELDSILELRP SAQDVLKGGS
ALSKPCLRSL IISGYNPVPA FFRTKGHLLY LQAVTLEGET LHITATVSGF YVNKSSAIKF
DPTLKTDAAV CLTLYELLTK HSKKFASHLS QLEAALKAHE SVNYVKPISV FLHKTWFPSS
LPSNSIDFTE YQLEALNFQT ERNFNDEFQA VKETSSEDIV ARLEKEKLLN RVIHDFNVAA
SKGSMEIFYG NMVAMNPDAP RQEHIFLKNN IFYSFVSDLD GHYQDKGGDA AAHAASNQDL
HIIKTLLQSN MRSVRHLLTA VVEFGGVRIL AQSPVPGILD TAGMKFIKNE KGEEEAIQAK
NDITVCYGFD EASNKVIADA EFGSSLDDFA KVFHLKKHEV DGVELKVAST SKGVVGFDKR
NYILDLADNN PLDVGFALEN FDAVTDEKAR YPHRQTLLRR ELVEKWWFSK VDGTGSEMEA
AYEEGKFSYN PDAYKIEGIE DETVVELSDY LRKEVVPTLV KEVAEGSITA PFNGEHLVDI
MHKNGINIRY LGRVIELAEQ ELEAQRALRE AHLQQVEADN KEFTEWEANY LKHIESLIKE
RQVTIQKLLA EGKEVPAELK EELKLDDKEI RKPHEKEGVA VNNDQLSVLL TLAQIEIISR
SIKHVFRKHC HELPAVIIPT FIAFALNLLF GYCYNKAPIA EFPTDGSDID FAFTKLTREQ
LLSEISEQAV LRFRYTLPDG WESRYEHTPF ALLRPICNKF GIQLLNKEYF FTREQYQNWR
QAQDKKIRSK LVEPVSTFSI NDLSVRPIIK VATLTTGVSD DCWAQGAYMI NEEEKQATAL
ALFSQSIAFR EETSGYVHPT VAESYLALST IHSKLEKKSE AVALCRKACA IYERVCGFDS
FEMIRSLNNL AMLEMANDSP YNAALCLKTI MSILSVVIPV NHPATINSYS MLHSMCSSLQ
NSSAMIKVLN KLGDIIVEID GHKSLPYAVN ESRLANLYAS VGEYKRSLAC IESCYELFSK
ELGVNHKTTV ECNSWITGVE NLIESTSQSK ALAASKAAAA AKQGEKKPAQ KQQQSAELRD
KSIDELMNFI NGGSAPAKKS KKKKNAKK
