CLU_ASPCL
ID CLU_ASPCL Reviewed; 1259 AA.
AC A1CKI4;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Protein TIF31 homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu1 {ECO:0000255|HAMAP-Rule:MF_03013}; Synonyms=tif31;
GN ORFNames=ACLA_038730;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBUNIT: May associate with the eukaryotic translation initiation
CC factor 3 (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; DS027056; EAW09658.1; -; Genomic_DNA.
DR RefSeq; XP_001271084.1; XM_001271083.1.
DR AlphaFoldDB; A1CKI4; -.
DR SMR; A1CKI4; -.
DR STRING; 5057.CADACLAP00003666; -.
DR PRIDE; A1CKI4; -.
DR EnsemblFungi; EAW09658; EAW09658; ACLA_038730.
DR GeneID; 4703296; -.
DR KEGG; act:ACLA_038730; -.
DR VEuPathDB; FungiDB:ACLA_038730; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_2_0_1; -.
DR OMA; VSGFYVN; -.
DR OrthoDB; 60958at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR GO; GO:0051640; P:organelle localization; IEA:UniProt.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 1.25.40.10; -; 2.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12601; PTHR12601; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51823; CLU; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1259
FT /note="Clustered mitochondria protein homolog"
FT /id="PRO_0000366393"
FT DOMAIN 324..568
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 982..1015
FT /note="TPR 1"
FT REPEAT 1024..1057
FT /note="TPR 2"
FT REPEAT 1066..1099
FT /note="TPR 3"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1229..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1259 AA; 140392 MW; E3480B6B2703E7C4 CRC64;
MSQTNGNMEH SKETPQSQEV EQLTNGNHPE EQQEEEENNG GLFQISVKLP HEPHKIQVMV
SSQEQVQDVR QSIVELPGTF QYTCFHLEFN GKRINDFVEL SEVEDLKADS EIVLVEDPYT
EKEARMHTVR IRDLVGAAGD RVDNLQGLDA GLSLHDSVTA EAAASEEKEH SLSKYDITAS
PSLKTILPRD EAPLPKTVKS ISLSAWNPPP YHLRQKGHLL YLQVATNEGE QFQVTSHVSG
FYVNKCSNAK FDPSPRTIPK KVSAHSLLTL ISKISPSFNT AFEALQESNN QKDLLTTFPF
QNAIPNSPWL VPPPSSNVNV HQADITRSQE SYLISGVDNA ETLRDWNEEF QTTRELPRET
VQDRVFRERL TSKLFADYNE AAARGAVLVA RGEVAPLNPT EDRDAQIFVY NNIFYSFGAD
GVGTFASEGG DEAARVAVGK DVLGIKAVNQ LDINGLFTPG TVVVDYLGKR IVGQSIVPGI
FKQREPGEHQ IDYGGVEGKD VVATHPDFVS VFEKMSKALR IKKHAVWDKD SKRHDLEGSV
ETKGLLGTDG RKYVLDLYRV TPLDVMWQEE PNSEEYPHRM SVLRLELVEA YWRSKMSQYV
KAEVERRRAV KAEAEKEKPA ESSESKEQDS EEKTEEKTEE SSDQERVDIS GFQLALNPDV
CSGQVPQTDE EKQQWAEDEK EVRDACDFLR SKVMPELVQD LHDGDVGFPM DGQSLGQLLH
KRGINIRYLG KLAQLSKEKG ARLDALTTLL IQEMIARAFK HIANRFMRNV PAPFVASCVA
HLLNCLLGAD VNANPRAEID ASLREFYPEG DFTFETVTPE TLRAEIEQQV ALRYRFTLES
EWFASLRHLQ LLRDIAIKLG LQLGAREYAF TKDQLPPKVP VVNGANNAAQ DEGKKKKKKG
ADKSPSRAIV EEKPAVSIVP DDIVNVVPLV KDASPRSSLA EEALEAGRIS LMQNQKQLGQ
ELILESLSLH EQIYGILHPE VAKLYHQLSM LYYQTDEKEA AVELARKAVI VTERTLGVDS
ADTILAYLNL SLFEHASGNT KTALVYIKHA MDLWKIIYGP NHPDSITTMN NAAVMLQHLK
QYADSRKWFE ASLSVCESLF GKQSINTATI LFQLAQALAL DQDSKGAVGK MRDAYNIFLS
QLGPDDRNTK EAETWLEQLT QNAVSIAKHA KDIQARRLRR INMNPRVTTL GTKVQPQVGQ
TAPEASGAKN AANASLDSRS IDELLKFIEG GDTSSSRSKQ KKRAAASNPK LRGSKKSSA
